1. Haplotypes in the GC, CYP2R1 and CYP24A1 Genes and Biomarkers of Bone Mineral Metabolism in Older Adults
- Author
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Ana Fernández-Araque, Andrea Giaquinta-Aranda, Carmelo Moreno-Sainz, María Cruz Martínez-Martínez, Verónica Velasco-González, María Sainz-Gil, Luis H. Martín-Arias, Silvia Carretero-Molinero, Miguel García-Hidalgo, and Zoraida Verde
- Subjects
Male ,elderly ,Polymorphism, Single Nucleotide ,Article ,White People ,Sex Factors ,genetic polymorphisms ,Bone Density ,Humans ,TX341-641 ,phosphorus ,Vitamin D ,Cytochrome P450 Family 2 ,Vitamin D3 24-Hydroxylase ,25 hydroxy vitamin D ,albumin ,calcium ,intact parathyroid hormone ,GC ,CYP2R1 ,CYP24A1 ,Serum Albumin ,Aged ,Aged, 80 and over ,Nutrition and Dietetics ,Nutrition. Foods and food supply ,Vitamin D-Binding Protein ,Cross-Sectional Studies ,Haplotypes ,Parathyroid Hormone ,Creatinine ,Cholestanetriol 26-Monooxygenase ,Female ,Food Science - Abstract
Candidate gene studies have analyzed the effect of specific vitamin D pathway genes on vitamin D availability; however, it is not clear whether genetic variants also affect overall bone metabolism. This study evaluated the association between genetic polymorphisms in GC, CYP2R1 and CYP24A1 and serum levels of total 25(OH)D, iPTH and other mineral metabolism biomarkers (albumin, total calcium and phosphorus) in a sample of 273 older Spanish adults. We observed a significant difference between CYP2R1 rs10741657 codominant model and total 25(OH)D levels after adjusting them by gender (p = 0.024). In addition, the two SNPs in the GC gene (rs4588 and rs2282679) were identified significantly associated with iPTH and creatinine serum levels. In the case of phosphorus, we observed an association with GC SNPs in dominant model. We found a relationship between haplotype 2 and 25(OH)D levels, haplotype 4 and iPTH serum levels and haplotype 7 and phosphorus levels. In conclusion, genetic variants in CYP2R1 and GC could be predictive of 25(OH)D and iPTH serum levels, respectively, in older Caucasian adults. The current study confirmed the role of iPTH as one of the most sensitive biomarkers of vitamin D activity in vivo.
- Published
- 2022