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1. Predictors Associated with Increase in Skeletal Muscle Mass after Sustained Virological Response in Chronic Hepatitis C Treated with Direct Acting Antivirals

Author

Kazunori Yoh, Hiroki Nishikawa, Hirayuki Enomoto, Akio Ishii, Yoshinori Iwata, Yuho Miyamoto, Noriko Ishii, Yukihisa Yuri, Kunihiro Hasegawa, Chikage Nakano, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Ryo Takata, Hiroko Iijima, and Shuhei Nishiguchi

Subjects
chronic hepatitis C, direct acting antiviral, sustained virological response, skeletal muscle mass, Nutrition. Foods and food supply, TX341-641
Abstract

Aims: We aimed to examine changes in skeletal muscle mass in chronic hepatitis C (CHC) patients undergoing interferon (IFN)-free direct acting antivirals (DAAs) therapy who achieved sustained virological response (SVR). Patients and methods: A total of 69 CHC patients treated with DAAs were analyzed. We compared the changes in skeletal muscle index (SMI) using bio-impedance analysis at baseline and SMI at SVR. SMI was calculated as the sum of skeletal muscle mass in upper and lower extremities divided by height squared (cm2/m2). Further, we identified pretreatment parameters contributing to the increased SMI at SVR. Results: SMI in males at baseline ranged from 6.73 to 9.08 cm2/m2 (median, 7.65 cm2/m2), while that in females ranged from 4.45 to 7.27 cm2/m2 (median, 5.81 cm2/m2). At SVR, 36 patients (52.2%) had increased SMI as compared with baseline. In the univariate analysis, age (p = 0.0392), hyaluronic acid (p = 0.0143), and branched-chain amino acid to tyrosine ratio (BTR) (p = 0.0024) were significant pretreatment factors linked to increased SMI at SVR. In the multivariate analysis, only BTR was an independent predictor linked to the increased SMI at SVR (p = 0.0488). Conclusion: Pretreatment BTR level can be helpful for predicting increased SMI after SVR in CHC patients undergoing IFN-free DAAs therapy.

Published
2017
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2. Comparison of Prognostic Impact between the Child-Pugh Score and Skeletal Muscle Mass for Patients with Liver Cirrhosis

Author

Hiroki Nishikawa, Hirayuki Enomoto, Akio Ishii, Yoshinori Iwata, Yuho Miyamoto, Noriko Ishii, Yukihisa Yuri, Kunihiro Hasegawa, Chikage Nakano, Takashi Nishimura, Kazunori Yoh, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Ryo Takata, Hiroko Iijima, and Shuhei Nishiguchi

Subjects
liver cirrhosis, bioimpedance analysis, skeletal muscle mass index, Child-Pugh score, prognosis, Nutrition. Foods and food supply, TX341-641
Abstract

Aims: To investigate the influence of skeletal muscle mass index (SMI) as determined by bioimpedance analysis (BIA) (appendicular skeletal muscle mass/(height)2) on survival by comparing the Child-Pugh score in patients with liver cirrhosis (LC, n = 383, average age = 65.2 years). Patients and methods: In terms of comparison of the effects of SMI and other markers on survival, we used time-dependent receiver operating characteristics (ROC) analysis. Results: The average SMI for male was 7.4 cm2/m2 whereas that for female was 6.0 cm2/m2 (p < 0.0001). As for the Child-Pugh score, five points were in the majority, both in males (51.7%, (106/205)) and females (44.9%, (80/178)). For both genders, the survival curve was well stratified according to SMI (p < 0.0001 for males and p = 0.0056 for females). In the multivariate analysis for survival, SMI and Child-Pugh scores were found to be significant both in males and females. In time-dependent ROC analyses, all area under the ROCs (AUROCs) for SMI in each time point were higher than those for Child-Pugh scores in males, while in females AUROCs for Child-Pugh scores at each time point were higher than those for SMI. Conclusion: SMI using BIA can be helpful for predicting outcomes, at least in male LC patients.

Published
2017
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3. Impact of Virtual Touch Quantification in Acoustic Radiation Force Impulse for Skeletal Muscle Mass Loss in Chronic Liver Diseases

Author

Hiroki Nishikawa, Yoshiyuki Sakai, Chikage Nakano, Yuho Miyamoto, Akio Ishii, Kazunori Yoh, Hiroko Iijima, Yukihisa Yuri, Hirayuki Enomoto, Takashi Nishimura, Nobuhiro Aizawa, Tomoyuki Takashima, Ryo Takata, Kunihiro Hasegawa, Noriko Ishii, Shuhei Nishiguchi, Yoshinori Iwata, and Naoto Ikeda

Subjects
Male, Multivariate analysis, Body Mass Index, 0302 clinical medicine, Electric Impedance, Medicine, Aged, 80 and over, Nutrition and Dietetics, Receiver operating characteristic analysis, Age Factors, Middle Aged, virtual touch quantification, medicine.anatomical_structure, bio-electronic impedance analysis, liver fibrosis marker, 030220 oncology & carcinogenesis, Area Under Curve, Cardiology, Body Composition, Elasticity Imaging Techniques, 030211 gastroenterology & hepatology, Female, skeletal muscle mass, predictive ability, Adult, medicine.medical_specialty, Adolescent, education, Independent predictor, Article, End Stage Liver Disease, 03 medical and health sciences, Young Adult, Internal medicine, mental disorders, Humans, In patient, Muscle, Skeletal, Aged, Receiver operating characteristic, business.industry, fungi, Skeletal muscle, Reproducibility of Results, Skeletal muscle mass, Surgery, ROC Curve, business, Body mass index, Food Science
Abstract

Background and aims: We sought to clarify the relationship between virtual touch quantification (VTQ) in acoustic radiation force impulse and skeletal muscle mass as assessed by bio-electronic impedance analysis in patients with chronic liver diseases (CLDs, n = 468, 222 males and 246 females, median age = 62 years). Patients and methods: Decreased skeletal muscle index (D-SMI) was defined as skeletal muscle index (SMI)

Published
2017

4. Comparison of Prognostic Impact between the Child-Pugh Score and Skeletal Muscle Mass for Patients with Liver Cirrhosis

Author

Akio Ishii, Hirayuki Enomoto, Ryo Takata, Noriko Ishii, Shuhei Nishiguchi, Yuho Miyamoto, Hiroki Nishikawa, Hiroko Iijima, Yoshiyuki Sakai, Chikage Nakano, Kunihiro Hasegawa, Yoshinori Iwata, Tomoyuki Takashima, Kazunori Yoh, Yukihisa Yuri, Takashi Nishimura, Naoto Ikeda, and Nobuhiro Aizawa

Subjects
Male, medicine.medical_specialty, Cirrhosis, Multivariate analysis, Child-Pugh score, liver cirrhosis, education, bioimpedance analysis, skeletal muscle mass index, prognosis, lcsh:TX341-641, Gastroenterology, Article, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, mental disorders, medicine, Health Status Indicators, Humans, In patient, Muscle, Skeletal, Survival analysis, Aged, Nutrition and Dietetics, Receiver operating characteristic, business.industry, Child–Pugh score, fungi, Middle Aged, Skeletal muscle mass, medicine.disease, Surgery, Bioimpedance Analysis, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, business, lcsh:Nutrition. Foods and food supply, Biomarkers, Food Science
Abstract

Aims: To investigate the influence of skeletal muscle mass index (SMI) as determined by bioimpedance analysis (BIA) (appendicular skeletal muscle mass/(height)2) on survival by comparing the Child-Pugh score in patients with liver cirrhosis (LC, n = 383, average age = 65.2 years). Patients and methods: In terms of comparison of the effects of SMI and other markers on survival, we used time-dependent receiver operating characteristics (ROC) analysis. Results: The average SMI for male was 7.4 cm2/m2 whereas that for female was 6.0 cm2/m2 (p < 0.0001). As for the Child-Pugh score, five points were in the majority, both in males (51.7%, (106/205)) and females (44.9%, (80/178)). For both genders, the survival curve was well stratified according to SMI (p < 0.0001 for males and p = 0.0056 for females). In the multivariate analysis for survival, SMI and Child-Pugh scores were found to be significant both in males and females. In time-dependent ROC analyses, all area under the ROCs (AUROCs) for SMI in each time point were higher than those for Child-Pugh scores in males, while in females AUROCs for Child-Pugh scores at each time point were higher than those for SMI. Conclusion: SMI using BIA can be helpful for predicting outcomes, at least in male LC patients.

Published
2017

5. Predictors Associated with Increase in Skeletal Muscle Mass after Sustained Virological Response in Chronic Hepatitis C Treated with Direct Acting Antivirals

Author

Naoto Ikeda, Noriko Ishii, Shuhei Nishiguchi, Hiroko Iijima, Kazunori Yoh, Akio Ishii, Yukihisa Yuri, Nobuhiro Aizawa, Tomoyuki Takashima, Hiroki Nishikawa, Yuho Miyamoto, Kunihiro Hasegawa, Yoshiyuki Sakai, Chikage Nakano, Takashi Nishimura, Ryo Takata, Hirayuki Enomoto, and Yoshinori Iwata

Subjects
Male, Time Factors, Sustained Virologic Response, Hepacivirus, Gastroenterology, Virological response, 0302 clinical medicine, direct acting antiviral, Electric Impedance, Hyaluronic Acid, Aged, 80 and over, Univariate analysis, Nutrition and Dietetics, biology, Middle Aged, Viral Load, Treatment Outcome, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Body Composition, Female, 030211 gastroenterology & hepatology, sustained virological response, lcsh:Nutrition. Foods and food supply, Viral load, Adult, medicine.medical_specialty, education, lcsh:TX341-641, Antiviral Agents, Article, 03 medical and health sciences, Chronic hepatitis, Internal medicine, mental disorders, medicine, Humans, chronic hepatitis C, skeletal muscle mass, Muscle, Skeletal, Aged, Retrospective Studies, business.industry, fungi, Skeletal muscle, Retrospective cohort study, Hepatitis C, Chronic, biology.organism_classification, Skeletal muscle mass, Surgery, Logistic Models, Multivariate Analysis, Tyrosine, business, Amino Acids, Branched-Chain, Biomarkers, Food Science
Abstract

Aims: We aimed to examine changes in skeletal muscle mass in chronic hepatitis C (CHC) patients undergoing interferon (IFN)-free direct acting antivirals (DAAs) therapy who achieved sustained virological response (SVR). Patients and methods: A total of 69 CHC patients treated with DAAs were analyzed. We compared the changes in skeletal muscle index (SMI) using bio-impedance analysis at baseline and SMI at SVR. SMI was calculated as the sum of skeletal muscle mass in upper and lower extremities divided by height squared (cm2/m2). Further, we identified pretreatment parameters contributing to the increased SMI at SVR. Results: SMI in males at baseline ranged from 6.73 to 9.08 cm2/m2 (median, 7.65 cm2/m2), while that in females ranged from 4.45 to 7.27 cm2/m2 (median, 5.81 cm2/m2). At SVR, 36 patients (52.2%) had increased SMI as compared with baseline. In the univariate analysis, age (p = 0.0392), hyaluronic acid (p = 0.0143), and branched-chain amino acid to tyrosine ratio (BTR) (p = 0.0024) were significant pretreatment factors linked to increased SMI at SVR. In the multivariate analysis, only BTR was an independent predictor linked to the increased SMI at SVR (p = 0.0488). Conclusion: Pretreatment BTR level can be helpful for predicting increased SMI after SVR in CHC patients undergoing IFN-free DAAs therapy.

Published
2017

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