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Introduction: the prevalence of osteoporosis among candidates for lung transplantation is high and its pathophysiology is multifactorial. Objectives: to evaluate differences in bone mineral density, risk of fractures and bone remodeling markers in patients with terminal lung disease, at the time they are evaluated for lung transplantation, comparing two types of pathologies. Material and methods: fifty-nine subjects, proposed to receive a lung transplant due to advanced lung disease, were included in this study. They were divided into two groups according to their respiratory pathology: chronic obstructive pulmonary disease (COPD) and diffuse interstitial pulmonary disease (ILD). Demographic data were collected and bone densitometry, blood analysis with markers of bone remodeling, spirometry, six-minute walk test (6MWT), echocardiography and cardiac catheterization were performed Results: no differences were found between the groups, regarding their age, sex, BMI or exposure to tobacco. A higher prevalence of osteoporosis and a higher FRAX were observed in the group with COPD. Regarding bone remodeling markers, higher parathyroid hormone (PTH) and higher osteocalcin were found in the COPD group. Vitamin D was lower in COPD patients. Conclusions: two out of three of the patients evaluated for lung transplantation had osteopenia or osteoporosis. The prevalence of osteoporosis and FRAX is higher in COPD patients. Vitamin D supplementation should be considered in certain patients. Differences in bone remodeling markers may be useful for suspected osteoporosis and therapeutic management. [ABSTRACT FROM AUTHOR]

Introduction: ferric carboxymaltose (CF) is an intravenous preparation that helps the rapid correction of anemia with a lower risk of adverse reactions. However, an association has been found between the administration of CF and the development of hypophosphatemia. Case report: we present the clinical case of a 57-year-old patient with a history of iron de-ficiency anemia who, after receiving treatment with CF (Ferinjet®) chronically, develops a clinical of severe muscle weakness. Laboratory tests showed hypophosphatemia, normocalcemia, normal vitamin D level (after correction) and increased renal excretion of phosphorus. After study, the diagnosis of chronic hypophosphatemia secondary to the use of CF is reached. Discussion: CF can cause an increase in FGF-23 which acts at the renal level inducing phosphaturia, which can generate severe hypophosphatemia. This case demonstrates the importance of recognizing and treating this clinical entity in time. [ABSTRACT FROM AUTHOR]

Background: hypovitaminosis D is frequent in kidney transplant recipient (KTR) patients and is associated with deleterious effects both at the bone and extraosseous levels. Treatment with cholecalciferol is effective for the normalization of 25(OH)D, demonstrating a beneficial effect on the calcium-tropic axis in other populations; however, its effect on the PTH/vitamin D/calcium and FGF23/klotho/phosphorus axis in RTR has not been reported. The aim of this study was to evaluate the effect of normalization of serum 25(OH)D concentrations on the PTH/vitamin D/calcium-FGF23/klotho/phosphorus axis in KTR treated with cholecalciferol, as well as the association between the components of this axis. Methods: a prospective study in 23 KTR with hypovitaminosis D, with evolution from 1 to 12 months post-transplantation, an estimated glomerular filtration rate > 60 mL/min/1.73 m2 and a history of primary nephropathy treated with cholecalciferol, in whom the PTH/vitamin D/calcium and FGF23/klotho/phosphorus axis was evaluated during the state of hypovitaminosis D and at normalization of 25(OH)D. Results: at the normalization of 25(OH)D, a reduction in PTH [103 (58.5-123.9) vs 45.6 (30.1-65.1) pg/mL; p = 0.002] and an increase in serum phosphorus [3.1 (2.3-3.5) vs 3.3 (3-3.6) mg/dL; p = 0.01] were evident, with no differences in calcium, klotho and FGF23 concentrations. The time to achieve normalization of 25(OH)D was 12 weeks (RIC, 4-12), with a dose of 5000 IU/day (RIC, 4000-6000). A positive association between klotho and PTH was corroborated (r = 0.54; p = 0.008; linear regression, ß = 0.421; B = 0.004; 95 % CI, 0.003-0.007; p = 0.045). Conclusions: treatment with cholecalciferol is effective for the normalization of 25(OH)D, with a beneficial effect on calcium-phosphotropic metabolism characterized by a reduction in PTH concentration, without significant changes in calcemia or calciuria, as well as an increase in phosphatemia, without modifications in FGF23 or klotho concentrations. [ABSTRACT FROM AUTHOR]

Introduction: vitamin D plays a key role in regulating insulin secretion and its deficit seems to confer an increased risk of developing diabetes mellitus. In this study, we have tried to analyze the prevalence of vitamin D deficiency in our type 1 diabetic children population and if their deficiency is related to a worse control of the disease, as well as with their bone and lipid metabolism. Material and methods: this is a retrospective study, in which both clinical and laboratory data were available for 124 children, who were controlled in the Pediatric Diabetes Unit of our Hospital. Results: the median vitamin D concentration of the total sample was 25.41 (7.43) ng/ml, higher in males than in females (p = 0.006); 43.55 % of patients had good metabolic control, with glycosylated hemoglobin lower than 7.5 %. Slightly lower glucose and cholesterol concentrations and higher bone alkaline phosphatase concentrations were found, when vitamin D concentration was ≥ 20 ng/ml. Conclusions: we have not found any significant differences in relation to metabolic control between children with sufficient and insufficient con)centration of vitamin D. The children in the present study presented very similar vitamin D concentrations to those found in a study made in healthy children, and a good metabolic control of their diabetes, with bone and lipid profiles being more favorable when they had good metabolic control. [ABSTRACT FROM AUTHOR]

Introduction: vitamin D plays a key role in regulating insulin secretion and its deficit seems to confer an increased risk of developing diabetes mellitus. In this study, we have tried to analyze the prevalence of vitamin D deficiency in our type 1 diabetic children population and if their deficiency is related to a worse control of the disease, as well as with their bone and lipid metabolism.Material and Methods: this is a retrospective study, in which both clinical and laboratory data were available for 124 children who were controlled in the Pediatric Diabetes Unit of our Hospital.Results: the median vitamin D concentration of the total sample was 25.41 (7.43) ng/ml, higher in males than in females (p = 0.006); 43.55 % of patients had good metabolic control with glycosylated hemoglobin lower than 7.5 %. Slightly lower glucose and cholesterol concentrations and higher bone alkaline phosphatase concentrations were found when vitamin D concentration was ≥ 20 ng/ml.Conclusions: we have not found any significant differences in relation to metabolic control between children with sufficient and insufficient concentration of vitamin D. The children in the present study presented very similar vitamin D concentrations to those found in a study made in healthy children, and a good metabolic control of their diabetes, with bone and lipid profiles being more favorable when they had good metabolic control. [ABSTRACT FROM AUTHOR]

Introduction: Vitamin D is a key nutrient for health. Recent research has shown that it is not only necessary for the maintenance of bone health, but also for the prevention of cardiovascular diseases, insulin resistance, respiratory diseases, infections, and cancer, among others. Solar synthesis of vitamin D is usually insufficient, so it is necessary to provide enough vitamin D through the diet in order to maintain an adequate nutritional status. Studies carried out in Spain and other countries have shown that serum levels of the vitamin were usually insufficient and that average dietary intakes were well below those marked as recommended, while the main food sources of vitamin D were fatty fish, breakfast cereals, eggs, and dairy. Food sources of vitamin D are scarce, and it is naturally located in the fatty part of foods of animal origin, and in the liver and viscera. Fortifying foods that are not natural food sources of vitamin D but are regularly consumed by a significant percentage of the population, is a strategy that could help to increase vitamin D intake. In this regard, dairy products and breakfast cereals are two of the most widely used food matrices for vitamin D fortification, and their incorporation into the usual diet has proven to be an effective strategy to improve the nutritional situation of the population in vitamin D. [ABSTRACT FROM AUTHOR]

Introduction: International health institutions have implemented protocols and nutritional health policies in the promotion of health and brain development. However, these policies do not usually extend to preschool age, being a stage of important changes and very dynamic development. Therefore the objective of this work is to carry out a review of the information available about nutritional needs throughout the process of human development, emphasizing the main micronutrients, their role in development and what the evidence tells us about the effects of it lack. A review of scientific evidence and recommendations of international scientific societies has been carried out. Different nutrients are required for different parts of a baby's development, including Vitamin D and calcium for bone development, DHA and choline for brain development as well as iron, zinc, vitamins A, D, B12 and folate, which meet different important roles and whose deficiencies lead to serious health disorders. Childhood is a critical period in which the foundations for future well-being are laid. A good nutritional status during childhood and adolescence is vital for normal growth and development. However, studies in Spanish pediatric populations indicate a lack of micronutrients (especially vitamin D, E, folate, calcium, and magnesium) in the diet of more than half of participating children. There may be situations of risk of suffering from vitamin and mineral deficiencies. Appropriate supplementation can provide nutrients during periods of increased physical and mental exertion, illness, and when dietary intake is not optimal. [ABSTRACT FROM AUTHOR]

Introduction: Introduction: vitamin D is a fundamental biomolecule for multiple biological processes in women of childbearing age; it is also one of the most important biomarkers in reproduction. Objective: to determine the prevalence of vitamin D deficiency and insufficiency and associated factors in Colombian women between 18 and 49 years of age. Methodology: an analytical cross-sectional study; it is a secondary analysis of the Encuesta de Situación Nutricional de Colombia, of 2015. A total of 7181 women between 18 and 49 years old, of childbearing age, who were not pregnant were evaluated. Vitamin D levels were estimated through chemiluminescence immunoassay. Sociodemographic, anthropometric and frequency-of-food-consumption characteristics were evaluated. A general description of the prevalence of vitamin D insufficiency and deficiency was made for each of the variables of interest through absolute and percentage frequencies. To estimate the association between the different characteristics of interest and vitamin D insufficiency and deficiency, multivariate binomial and multinomial logistic regression models were used. Results: the prevalence of vitamin D deficiency was 23.8 % and that of insufficiency was 46.8 %; for insufficiency and deficiency the result was 70.6 %. Quartile IV of wealth (OR: 3.21; 95% CI: 2.16-4.77); abdominal obesity (OR: 1.43; IC 95 %: 1.15-1.78), and the Bogotá region (OR: 3.98; 95 % CI: 2.48-6.38) showed an association with vitamin D insufficiency and deficiency. Conclusion: a high prevalence of vitamin D insufficiency and deficiency was identified. Therefore, comprehensive interventions involving nutritional and educational components are recommended. [ABSTRACT FROM AUTHOR]

Introduction: Introduction: vitamin D maintains the concentration of calcium and phosphorus within the physiological range, allowing normal metabolism and bone mineralization. Recently, vitamin D deficiency has been related not only with rickets but also with an increased risk of other pathologies. The aim of this descriptive, observational, cross-sectional study was to assess vitamin D concentration levels in a healthy pediatric population, as well as the current situation of prophylaxis. Vitamin D determination was measured by serum 25-hydroxyvitamin D (25(OH)D) concentration. Methods: a total of 258 healthy patients between 3 months and 15 years of age were enrolled (6.77 ± 3.95 years; 73.6 % were male). Results: the mean value of 25-hydroxyvitamin D was 26.60 ng/mL ± 8.02 ng/mL, and up to 20.9 % of the population showed insufficient levels. Statistically significant differences in vitamin D levels were observed between ages (p = 0.002), ethnicity groups (p = 0.038), and skin types (p = 0.000). In addition, a higher prevalence of vitamin D insufficiency in children who had never previously received vitamin D supplementation (41.6 %) was observed compared to those that had taken supplementation in the first year of life (16.7 %). Conclusion: our study shows a high prevalence of vitamin D deficiency among healthy children, and the benefit of prophylaxis with vitamin D supplementation. [ABSTRACT FROM AUTHOR]

The article titled "Vitamin D deficiency in patients with epilepsy: considerations to take into account" reports on a preliminary study that aimed to find a possible association between epilepsy and vitamin D deficiency in patients over 18 years old. Body composition and vitamin D levels were evaluated in 32 patients with epilepsy, finding that 75% of them were overweight and 78% had low levels of vitamin D. Although no statistical association was found between overweight and vitamin D deficiency, other studies have shown a clear relationship between epilepsy and deficiency of this vitamin due to the use of anticonvulsant drugs. It is recommended to perform annual measurements of vitamin D and calcium levels in these patients, as well as consider performing bone densitometry in cases of chronic exposure to anticonvulsant drugs. [Extracted from the article]

The article analyzes the incidence of hip fractures in older adults during the pandemic and the effect of vitamin D on this condition. It is mentioned that in Chile, hip fractures in older adults decreased during the pandemic due to reduced mobility and increased family support. It is highlighted that hip fractures are more common in women over 50 years old and the importance of consuming vitamin D and sun exposure to prevent this condition is mentioned. Other risk factors and prevention measures are also mentioned, such as the consumption of estrogens and progesterones and the evaluation of risk factors and risky conditions at home. The importance of implementing public policies and health programs for the care and prevention of falls in older adults is emphasized. [Extracted from the article]

Introduction: Milk and dairy products are key foods during all stages of life within a balanced Western diet. In recent decades, their consumption has decreased significantly. In parallel, an increase in some pathological alterations caused by the deficit of some micronutrients present in dairy products, mainly calcium and vitamin D, has been detected, resulting in a serious public health problem in certain groups of population. In order to avoid these deficiencies, foods enriched in these components have been launched into the market. Within them, enriched milks and dairy products stand out since they allow better bioavailability of calcium and are natural sources of vitamin D. Several studies have been carried out to demonstrate the benefit of supplementation with calcium and vitamin D enriched milks in vulnerable groups such as older adults and postmenopausal women. Those studies have reported a substantial improvement of bone turnover and an increase of bone density and strength. The aim of the present work is to revise the importance of milk-derived calcium intake on health, and the usefulness of calcium-enriched milks for allowing adequate calcium consumption without dietary modifications in certain groups of population. Likewise, it is intended to clarify the errors and myths that have recently arisen in relation to certain foods that seek to replace milk and dairy product, based on their differences in composition, bioavailability and health effects. [ABSTRACT FROM AUTHOR]

Introduction: Introduction: interest in vegetarian diets is rising, however, it remains a very controversial topic, and with many reservations regarding it. Questions like their conceivable nutritional deficiencies, or if they are adequate or healthy, might be widely unknown. Objectives: exploring vegetarian diets, examining the current level of knowledge about them, and analyzing and improving, from a nutritional standpoint, the vegetarian menus of a restaurant with vegetarian options. Methods: this study was designed as an exploratory, crossover, descriptive study. Surveys with 17 items and a food frequency questionnaire were given among the customers of the restaurant. A total of 155 people, aged between 18 and 62, took part in it. A total of 30 menus were analyzed, and some suggestions were made in order to improve them. Results: out of the total sample, 138 people were omnivores, 12 people were vegetarians and two were vegans. More than half of the vegetarians did not know vitamin B12 is the only required supplement by default, and almost 60% of them stated never taking B12 supplements. The vegetarian menus which were analyzed provided a mean of 1,195 kcal, and covered 89% of the requirements of fiber, 212% of vitamin C, ≈30% of both calcium and zinc, 86% of iron, and 38% of B12. Conclusion: a great lack of knowledge regarding several aspects of vegetarian diets was found, even among vegetarian themselves. Informing the general public is essential for both avoiding dangerous nutritional deficiencies (like B12), and attracting more people towards this kind of diets, with all the benefits this would provide. In the vegetarian menus of Foodtopía, adequate levels of nutrients were observed. The main suggestions to improve the menus were: reducing the total calories and the amount of sunflower oil, and increasing the amount of legumes, nuts and seeds. [ABSTRACT FROM AUTHOR]

Introduction: apart from the known effects of vitamin D on phospho-calcium homeostasis, in recent years there is great interest in its extrabone effects.Objectives: to know the concentration of 25-hydroxyvitamin D (25[OH] D) in newly diagnosed patients of cancer and to verify if there are differences between the different types of cancer.Material and Methods: cross-sectional study of a cohort of recent diagnosed cancer patients who were referred to Endocrinology consultation for a nutritional pre-surgery evaluation. One hundred and thirty-nine medical histories were reviewed. The socio-demographic and biometric data and 25(OH) D concentration were collected.Results: seventy-one of 139 patients had urological cancer, 27 had colorectal cancer (CRC), 35 had head and neck cancer and six, other types of cancer. The mean concentration of 25(OH) D was 50.41 nmol/l (95% CI = 46.67-54.14); 57.97% of patients showed vitamin D deficiency (< 50 nmol/l) and 21.74%, insufficiency (50-75 nmol/l). We found a statistically significant higher prevalence of deficiency (p < 0.01) in head and neck cancer compared to urological cancer: 68.57% and 49.29%, respectively. Year season significantly modifies 25(OH) D concentration (p < 0.01).Conclusions: there is a high prevalence of vitamin D deficiency among recent diagnosed cancer patients (especially in CRC and head and neck cancer). The use of reference values adjusted by year season could improve the study of 25(OH) D concentrations. [ABSTRACT FROM AUTHOR]

Background: the main action of vitamin D is to maintain the concentration of calcium and phosphorus within the physiological range, allowing normal metabolism and bone mineralization. Vitamin D receptors have recently been described in many tissues, therefore vitamin D deficiency has been related not only to rickets, but also to increased risk of diabetes, obesity, cardiovascular, oncological, infectious and autoimmune diseases. Objective: the aim of the study was to know the vitamin D concentration in a healthy pediatric population and to verify its influential factors, as well as to analyze the current situation of vitamin D prophylaxis and to evaluate the effectiveness of current recommendations. Methods: one hundred and seven healthy patients aged between one and 15 years were selected, who required a blood test as a preoperative minor surgery and whose pathology did not influence the parameters of the study. Results: the sample analyzed had a total of 78.5% males and a mean age of 7.17 ± 3.79 years. Mean values of vitamin D were 26.07 ± 7.11 ng/ml; up to 72.9% had insufficient levels. The sample was divided into two groups: patients with hypovitaminosis D and patients with optimal vitamin D levels. A predominance of males with a higher body mass index, from immigrant parents, and the presence of extreme phototypes were observed in the hypovitaminosis group. There was also a higher risk of hypovitaminosis in those who had not performed prophylaxis during the first year of life. Conclusions: the high percentage of healthy children with vitamin D deficiency is evident, and current recommendations for prophylaxis are not carried out by the population as recommended by current guidelines. [ABSTRACT FROM AUTHOR]

Introduction: breast cancer (BC) is the most commonly diagnosed tumor in women and it continues to be the leading cause of cancer death in women. Quality of life decreases significantly during treatment and in the survivors. There is growing evidence linking the intake of certain foods, or their bioactive compounds, with better prognosis of the disease or improvements in physiological parameters that can increase BC patients' quality of life. But there are hardly any reviews to clarify the scientific evidence.Objectives: gathering and summarizing the available evidence on the effectiveness of the dietary compounds use as coadjuvants for BC treatment.Method: literature search using Pubmed to identify and analyze bioactive compounds as coadjvants for BC treatment.Results: all tested compounds showed antitumor effects in vitro. Vvitamin D decrease risk of bone fracture, and marine lipids may reduce bone resorption and inflammation.Conclusion: there are bioactive compounds with potential to improve the quality of life of women with BC. Vitamin D a marine lipids provide a solid quality scientific evidence. Despite this, more controlled clinical trials are required to establish a direct link between the use of these compounds and the tumor progression or patient survival. [ABSTRACT FROM AUTHOR]

Objective: To review the available scientific literature about the effects of nutritional status on the multiple sclerosis disease.Methods: A systematic review of the scientific literature in the Medline (PubMed), Scopus, Cochrane Library and Web of Science databases through November 2016. Search equation: ("Multiple Sclerosis"[Mesh] OR "Multiple Sclerosis"[Title/Abstract] OR "Disseminated Sclerosis"[Title/Abstract] OR "Multiple Sclerosis Acute Fulminating"[Title/Abstract]) AND ("Nutritional Status"[Mesh] OR "Nutritional Status"[Title/Abstract] OR "Nutrition Status"[Title/Abstract]). The quality of the selected articles was discussed using the STROBE questionnaire. The search was completed through experts inquiry and additional review of the bibliographic references included in the selected papers. The concordance between authors (Kappa index) had to be higher than 80% for inclusion in this review.Results: Of the 160 references recovered, after applying inclusion and exclusion criteria, 29 articles were selected for review. Concordance between evaluators was 100.00%. The most studies established vitamin D levels. Others focused their research on finding out which nutrient deficits might be related to the multiple sclerosis development.Conclusions: Vitamin D may influence multiple sclerosis improvement. Sunlight and physical activity would be important factors, with nutritional status, in the course of this disease. It is necessary to produce new specific works that will delve into the subject to find out more about the relationship between nutritional status and multiple sclerosis. [ABSTRACT FROM AUTHOR]

Introduction: Energy and nutrients obtained through food play an important role in the development and preservation of the immune system therefore any nutritional imbalance affects its competence and integrity.Objectives: Knowing the nutritional approach on different disorders of the immune system.Methods: A review has been carried out on the most prevalent immunological disorders in developed countries, the nutritional characteristics to which they are associated and their nutritional approach.Results: Nutritional treatment for immune disorders has focused in recent years on the role of PUFA-ω3 and vitamin D. Maintaining body weight, preventing malnutrition and protein catabolism are key strategies for nutritional treatment. This should be adapted to each disease stage because it is a dynamic process.Conclusions: Nutritional treatment for immunological disorders, especially in autoimmune diseases, is not always clear because they present acute and remission states. Anorexia is one of the most characteristic symptoms derived mainly from pharmacological treatment and inflammatory processes. Diet should be dense in nutrients that prevent deterioration.Nutritional treatment of immunological disorders should aim to maintain an optimal state of nutrition during symptomatic periods, prevent their deterioration during acute episodes and improve during stable periods free of symptoms. [ABSTRACT FROM AUTHOR]

Introduction: Nutrition research has traditionally promoted a nutrient-based approach; however, to evaluate population compliance with dietary recommendations, researchers have increasingly used dietary pattern analysis.Objective: To assess the relationship between dietary patterns and vitamin D and calcium intake in an adult Mexican population.Methods: We characterized the dietary patterns of 8,456 men and women aged 20-80 years who were participating in the Health Workers Cohort Study. Information on participants' sociodemographic conditions and physical activity was collected via self-administered questionnaires. A food frequency questionnaire was used to assess diet. In a cross-sectional analysis, we examined dietary patterns in relation to vitamin D and calcium consumption.Results: Factor analysis revealed 3 major dietary patterns. Pattern 1, labeled as "prudent pattern", was characterized by high positive loads for the consumption of fresh vegetables, fresh fruits, whole grains, oils, and legumes. The second dietary pattern, named as "dairy and fish pattern", was positively correlated with intake of dairy foods, fish and other seafood, milk and whole grains. Finally, dietary pattern 3 was associated with higher intake of red meat, soft drinks, fats, eggs, white meat and alcoholic beverages. Of these, the "dairy and fish pattern" was positively and significantly associated with vitamin D and calcium consumption (r = 0.42, p < 0.001; and r = 0.20, p < 0.001 respectively). Conversely, the third dietary pattern was negatively associated with vitamin D and calcium intake (r = -0.28, p < 0.001; and r = -0.41, p < 0.001, respectively).Conclusions: In summary, our findings show that dietary patterns represented by high consumption of milk, dairy products, whole grains, fish are associated with higher consumption of vitamin D and calcium in Mexican adult population. Additionally, our results highlight the importance of following an appropriate dietary pattern to achieve adequate consumption of nutrients. [ABSTRACT FROM AUTHOR]

Introduction: in older adults, deficit of Vitamin D and hip fractures are common. There exists relationships between both conditions, and it have been shown that supplementation of Vitamin D improve prognosis of hip fractures. In the case of Chile, information about relationship between Vitamin D and hip fractures is scarce.Objective: quantify plasma levels of vitamin D and relate them to the anatomical location of hip fracture.Methods: cross-sectional study. 222 Chilean adults ≥60 years, hospitalized for hip fracture between June, 2014 and June, 2015. We use data of medical records about gender, age, seasonality and anatomical location of hip fracture (intra and extracapsular). We measure plasmatic levels of Vitamin D (PLVD) and glomerular filtration rate (GFR) (MDRD-6). Kolmogorov-Smirnov test and non-parametric test were used. For determine relations between PLVD and anatomical location we use linear regression.Results: there was a predominance of women (80.6%). The average age was 80.7 years (SD=7.8). Intracapsular hip fractures were 43.2%. 80% of the sample presents Vitamin D in deficitary levels (n = 180). PLVD average was 13.3 ng/cc (SD=6.7), in subjects with intracapsular fractures were significantly lower (p<0.001).Conclusions: PLVD in subjects with hip fracture should be monitored, as there are differences according to anatomical location of the fracture. This precedent could favor the treatment and recovery of subjects presenting for the first time hip fracture. [ABSTRACT FROM AUTHOR]

Aims: to determine the characteristics of pediatric patients suffering from eating disorders that were hospitalized at Hospital Universitario de Canarias.Materials and Methods: a retrospective study in a cohort of pediatric patients diagnosed with eating disorders and admitted in our area was developed during the last seven years.Results: out of 35 patients in our study, 85.7 % were women, onset average age 13.5. 77.1% of the cases were diagnosed as anorexia nervosa- restrictive type. The most frequent analytical alterations, detected when patients were in hospital, consisted in a drop in plasma levels in retinol binding protein (RBP)- in 57.6% of the cases- and D hypovitaminosis- in 46.9 % of them: the use of high - calories supplements was required in 71.4% of patients during hospitalization. The average weight gain was higher when the body mass index (BMI) was smaller at patient's admission to hospital (p = 0,006). Conclussions: eating disorders are increasing in pediatric age: puberty is a special vulnerable period for its development, as well as medical complications secondary to malnutrition. Admission to hospital is an essential tool for handling many cases; taking the necessary monitoring leading to a weight increase, preventing complications in nutritional support and tackling the underlying psychopathology. Diagnosis and a precocious treatment are crucial to avoid an excessive weight loss and more complications. [ABSTRACT FROM AUTHOR]

Introduction and Objectives: evaluate vitamin D status and its association with chronic lung colonisation in Cystic Fibrosis patients.Material and Methods: descriptive cross-sectional multicenter study. From November 2012 to April 2014, at 12 national hospitals, 377 patients with Cystic Fibrosis were included. Vitamin D levels < 30 ng/ml were classified as insufficient. Chronic colonisation was considered if they had at least two positive cultures in the past year.Results: the median age was 8.9 years (2 months to 20 years). 65% had insufficient levels of vitamin D. There was an inverse correlation between age and vitamin D levels (r = -0.20 p < 0.001). Those diagnosed by screening, were younger and had higher levels of vitamin D. There was an inverse correlation between the number of colonisations and vitamin D levels (r = -0.16 p = 0.0015). Adjusting for age, pancreatic status and diagnosis by screening, colonization by S. aureus in 6 years, increased the risk of insufficient levels of vitamin D: OR 3.17 (95% CI 1.32 to 7.61) (p = 0.010) and OR 3.77 (95% CI 1.37 to 10 , 37) (p = 0.010), respectively.Conclusions: despite adequate supplementation, more than half of our patients did not achieve optimal levels of vitamin D. Regardless of age, diagnosis by screening or pancreatic status, chronic colonization by Pseudomonas sp. in children and adolescents and S. Aureus in infants and preschoolars increases the risk of developing vitamin D deficiency in these patients. [ABSTRACT FROM AUTHOR]

Introduction and objective: Evaluate the safety and efficacy of a novel polyvitaminic (Aquadek's®) in patients with Cystic Fibrosis (CF). Material and Methods: Prospective, longitudinal and non-randomized study. CF patients with pancreatic insufficiency and clinically stable were given Aquadek's® (two chewable tablets) daily for 12 months. Serum levels of retinol, beta-carotene, 25 OH vitamin D and a-tocopherol were evaluated twelve months before, at baseline and 12 months after. Statistical analysis: paired ttests. Results: 28 patients aged 6 to 39 years (median 18.5 years) were included. Aquadek's® supplementation led to an increase in vitamin A dose and a decrease in the number of tablets administered. At baseline, 89% had at least one vitamin deficiency (61% pro-Vitamin A and 54% vitamin D). After one year, serum beta-carotene levels were increases 160 (95% Cl 98-222) mcg/l (p <0.001) and decreased the percentage of patients with pro-vitamin A deficiency 46% (95% Cl 22-64) (p <0.001). The proportion of patients with vitamin I) insuficiency increased 18% (95% Cl 2-32) (p =0.025). In any case serum levels exceeded the upper limits used to assess the risk of toxicity. Conclusions: Two daily Aquadek's® chewable tablets are safe and effective for maintaining vitamin A and E status of CF patients older than 6 years, although it is insufficient to normalize serum 250 H vitamin D according to the current recommendations for this disease. [ABSTRACT FROM AUTHOR]

Objective: To analyze the vitamin D status and its relationship with metabolic syndrome (MS) risk factors in a group of Spanish schoolchildren. Material and methods: A group of 314 Spanish schoolchildren (8-13 years old) from A Coruña, Barcelona, Madrid, Seville and Valencia were studied. Anthropometric data on weight, height, waist and hip circumferences, and triceps skinfold, as well as blood pressure data were collected. Serum levels of glucose, triglycerides, HDL-c and 25-hydroxycholecalciferol (25 (OH) D) were assessed. Following Cook criterion, the following MS risk factors were defined: glucose ≥100 mg/dL; ≥P90 waist circumference; triglycerides> P90, HDL ≤P10; and sistolic and/or diastolic blood pressure > P90. Results: Mean serum 25(OH)D were 23.0±8.6 ng/mL. Forty seven percent of children had hypovitaminosis (20- 30 ng/mL) and 35% had vitamin deficiency (<20 ng/mL). Compared to the first tertile, children in the second tertile have a lower risk of elevated triglycerides (OR = 0.50 [CI = 0.25 to 0.99]; those in the the third tertile had lower risk of high blood pressure and triglycerides (0.60 [CI = 0.42 -0.86] and 0.50 [CI = 0.32 to 0.79], respectively). Conclusion: The prevalence of vitamin D deficiency is high in this group of Spanish schoolchildren. Low serum levels of vitamin D are associated with an increased risk of elevated triglycerides and blood pressure. [ABSTRACT FROM AUTHOR]

The article discusses the relationship between vitamin D, calcium, and multiple sclerosis. It points out that vitamin D deficiency can promote the development of the disease, so its consumption through supplements is recommended. However, high doses of vitamin D can have negative effects on health, such as fatigue and muscle weakness. It is also mentioned that hypercalcemia caused by excessive vitamin D consumption can activate T cells and perpetuate the disease. The importance of maintaining constant levels of vitamin D and undergoing regular clinical check-ups is emphasized. [Extracted from the article]

Background: Vitamin D can play an important role in maintaining bone health and in the prevention of some diseases. Few foods are a natural source of vitamin D and these are not normally consumed, being the most common oily fish and yolk. Aim: To analyze the intake and sources of vitamin D in schoolchildren aged 7-16 years. Methods: A representative sample of the Spanish population aged 7-16 years (n = 1,976) selected from ten Spanish provinces was studied. Dietary data were obtained by using a 3-day food record. The body weight and height were measured. Results and discussion: Mean vitamin D intake (1.63 (0.96-3.35) μg/day) was lower than the recommended intake (RI) in 85.4% of study participants and it was influenced by age (OR = 0.935; IC: 0.889-0.983; p < 0.01). The main sources of vitamin D were eggs (27.7%), followed by cereals (25.8%), fish (20.9%) and dairy products (12.7%). Additionally, it has been found that vitamin D RI can be adequately covered the greater the consumption of fish is (r = 0.734; p < 0.001). Thereby, an increase of one fish serving decreased a 72.5% the odds of not covering vitamin D RI. Conclusions: Vitamin D intake is lower than the recommended intake in a high percentage of the participants. Having into account that the contribution of vitamin D is mainly determined by fish, an increase in the consumption of this food group would be desirable. Young children merit special attention. [ABSTRACT FROM AUTHOR]

Both nutritional status and social-environmental factors influence elderly's health and quality of life. An inade-quate intake of protein, calcium and vitamin D affects bone health. Objectives: 1) To assess energy, protein, calcium and vitamin D intake in women ≥ 65 year of age (y); 2) To assess the contribution of residence place: family home (FH) o Public Homes (PH); 3) To evaluate the relationship between the dietary intake and the biochemical parameters. Populations: Forty-four ambulatory and clinically healthy women with (X ± SD) 75 ± 7 y and a body mass index 28 ± 4 kg/m². Methods: 1) Food frequency, sunlight exposure and socioeconomic status questionnaires; 2) Laboratory: Serum 25 hydroxyvitamin D (25OHD), crosslaps (CTX), calcium (sCa), phosphate, bone alkaline phosphatase and urine calcium/creatinine ratio (uCa/UCr) in 2-hour urine samples. Results: The total group showed intakes lower than the dietary reference intake, except regarding protein intake, with higher deficit in the PH group. The 88% showed vitamin D deficit (25OHD < 20 ng/ml). A positive correlation between 25OHD and vitamin D intake (r = 0.46; p < 0.007) and a negative correlation between 25OHD and CTX (r = -0.51; p < 0.03) in those subjects with 25OHD < 15 ng/ml. The levels of 25OHD, sCa and uCa/uCr were higher in the HF than in PH. Conclusion: Both the vitamin D deficiency and the inadequate intake of calcium and vitamin D might have deleterious bone health consequences. Nutritional educational programmes and vitamin D supplementation would be required for this specific age group, especially for high risk groups such as PH. [ABSTRACT FROM AUTHOR]

Introduction: Vitamin D is essential for the prevention of several chronic diseases. Although it can be synthesized at skin, this source is not always sufficient to meet their needs and the consumption of foods rich in it, such as egg, could be very beneficial in individuals who are at risk of deficiency. Objective: To study the relationship between vitamin D status and daily consumption of eggs in a group of schoolchildren. Methodology: A total of 564 school children between 9-12 years of the Community of Madrid were included. Food consumption and energy and nutrients intake (including eggs and vitamin D), were determined using a food intake record for 3 days. Body weight and height were measured and body mass index calculated. Total cholesterol, lipoprotein, triglycerides and serum vitamin D were analyzed. Results: The mean consumption of eggs was 32.7 ± 20.9 g/day (less than 0.5 egg/day recommended in the 3,63% of the schoolchildren). Schoolchildren were divided according to their consumption of eggs: ≥ 0.5 egg/day or < 0.5 egg/day (SH and IH groups, respectively). Vitamin D intake and serum levels were significantly higher in the SH group than in the IH. In addition, the former had lower risk of moderate vitamin D deficiency (< 50 nmol/L) (OR = 0.41 (0.19 to 0.88), P = 0.022). No significant differences between groups in relation to total cholesterol and triglycerides were observed. Conclusion: It is necessary to promote the consumption of at least 0.5 egg/day among children because of their high amount of vitamin D, which could prevent health problems. [ABSTRACT FROM AUTHOR]

Background: The accelerated bone demineralization that occurs during the menopause is very conditioned by the intake of calcium and vitamin D, therefore, the aim of the study is examine the adequacy of the diet regarding these nutrients in a menopausal women group. Methods: A representative sample of the Spanish woman population with ages ranging from 17 to 60 years (n = 547), selected from 10 provinces was studied. The group of 108 menopausal women (45-60 years) is given priority attention. The dietary study was performed using a 3-day diet record. Weight and height were measured and then body mass index (BMI) was calculated. Results: Calcium intake (992.1 ± 340.7 rag/day) was lower than the recommended intakes (RI) in 79.6% of the menopausal women (MW) (lower than 67 % of the 173 in the 30.6 %). Vitamin D intake (3.08 ± 3.6 µg/day) was even more unfavorable, since the contribution was 61.1% of the RI in MW, an 85.2% of them do not meet the RI and a 75.9% do not meet the 67% of the RI. A 72.6% of the studied women (68.5% of MW) do not meet the RI for calcium neither for vitamin D, while only the 4.0% of them meet the RI for both nutrients (3.7 of MW). Using a logistic regression analysis to examine the dietary modification that may be favorable to meet the RI for calcium and vitamin D simultaneously, having into account the influence of age and BMI, it is observed that the main factor is the consumption of dairy products [OR = 0.188 (0.108-0.327; p < 0.001)] and the same influence is observed when only menopausal women are analyzed [OR = 0.252 (0.067-0.946; p < 0.05)]. It is observed a decreased of BMI when the density of diet in calcium (r = -0.10) and in the vitamin D (r = -0.099) is increased, which suggested a possible role of these nutrients in weight control. Conclusions: A high proportion of the studied women have intakes of calcium and vitamin D lower than the recommended intakes and given that only a 3.7% of the menopausal women have adequate intakes for both nutrients, it is necessary to adopt urgent measures aimed to protect the bone health of the Spanish female population. [ABSTRACT FROM AUTHOR]

Background: Vitamin D and calcium play an important role in peak bone mass acquisition. Recent studies have suggested that vitamin D deficiency in children is widespread, mainly during infancy and adolescent years. However, the vitamin D status at others ages is unsufficiently investigated. Objectives: To determine the vitamin D status in prepubertal, healthy South European girls, and to examine the relationship between serum vitamin D concentrations, sun exposure, physical activity and dietary intake. Methods: A cross-sectional observational study was conducted on 56 Caucasian; healthy and pre-pubertal girls aged 7-10 years. Dietary information, amount of sunlight exposure and activity were estimated. Blood samples were extracted in the first week of December. Results: Vitamin D intake was below the international recommended references. Mean serum vitamin D was 40.07 ± 10.49 ng/ml. No girl presented a level lower than 20 ng/ml; 25% had levels between 20-30 ng/ml and 75% above 30 ng/ml. We have not found differences in vitamin D levels from the girls who did sport and those who were sedentary. Conclusions: Vitamin D status is suitable for prepubertal girls living in the South of Spain at the beginning of winter. However, it is necessary to follow-up girls and check and adequate vitamin D intake, as well as sufficient sun exposure. [ABSTRACT FROM AUTHOR]

Introduction: Different studies have observed deficiencies in vitamin D in a high percentage of schoolchildren, highlighting the importance of this problem in sunny populations, such as Spain, where this situation is frequently underestimated. Aim: To assess the adequacy of vitamin D intake and to find out the food sources of the vitamin in a representative sample of Spanish schoolchildren. Methods: A sample of 903 children (7 to 11 years) was studied. Ten Spanish cities were selected to be a representative sample of the Spanish schoolchildren population. Dietetic study was carried out using a three-day food record, including a Sunday. Vitamin D was compared to that recommended (RI) and energy intake was compared with energy expenditure estimated by measuring physical activity level. Weight and height were recorded and body mass index (BMI) was calculated. Results and discussion: Vitamin D intake (2.49±0.64 µg/day) allowed cover only 49.7% of the RI of the children. It was below of 100% of RI in 99.9% of the children, and in 78.7% it was below of 67% of RI. The vitamin intake was lower in girls, those younger than 7 years and in children with obesity than in boys, those older than 7 years and in children with normal weight. The main sources of the vitamin were eggs (28.12%), cereals (24.23 %), fish (20.06 %) and milk (14.42 % ). Conclusion: Vitamin D intake is inadequate in Spanish schoolchildren between 7 and 11 years. Taking into account that the consumption of foods which are the main source of vitamin D (fish, eggs, cereals, dairy products) is often lower than the recommended, approximating the diet to the theoretical ideal could help to improve the contribution of the vitamin. [ABSTRACT FROM AUTHOR]

Aim: To analyse the calcium contribution of one unit of fermented milk enriched with calcium and vitamin D in the daily calcium intake for postmenoupausic women. Subjects: 261 postmenoupausic women. Methods: 28 day duration of exploratoy, nutritional trial. All subjects received dietary advice on how to increase calcium intake in the daily diet and excercise recommendations with a unit of a fermented milk enriched with calcium and vitamin D (Densia(R)) which was comsumed daily for the 28 day duration trial. A dietary assesment was used to evaluate dietary intake of calcium at the beggining and at the end of the trial. Results: The average amount of calcium intake in miligrams was higher at the end of the trial versus the average intake at the begining of the trial. The number of women who achieved the calcium recommendation intake for their ages increased at the end of the trial. Conclusions: Dietetic methods and the daily consumption of a unit of fermented milk enriched with calcium and vitamin D increases the average daily dietetic contribution of calcium. However, a percentage of the subjects still presented a daily calcium intake below the dietary recommendations, suggesting the need to adopt more intense strategies to help increase daily recommended calcium intake. [ABSTRACT FROM AUTHOR]

Introduction: Vitamin D deficiency produces inadequate bone mineralization, proximal muscle weakness, abnormal gait and increased risk of falls and fractures. Moreover, in epidemiological studies, has been associated with increased risk of cancer, autoimmune diseases, type 1 and 2 diabetes, rheumatoid arthritis, multiple sclerosis, infectious diseases, cardiovascular diseases and depression. When synthesis through the skin by sun exposure is not possible and the patient can not eat by mouth, as in the advanced stages of various neurological diseases, the supply of vitamin D has to be done by enteral nutrition. Objectives: The aim of this study is to review the role of vitamin D in a common group of neurological conditions that often require artificial nutrition and analyze whether the vitamin D of different enteral nutrition formulas is adequate to meet the needs of this group of patients. Results: Numerous studies have shown the association between vitamin D deficiency and increased incidence of dementia, stroke and other neurodegenerative diseases. Interventions aimed to increase levels of vit. D and its effects on functional (falls, pain, quality of life) and cardiovascular goals (cardiovascular death, stroke, myocardial infarction, cardiovascular risk factors) have obtained as highlight data a clear reduction of falls and fractures, while the evidence for the other parameters studied is still limited and inconsistent. The content of calcium and vitamin D of enteral formulas is legislated in our country. The total amount of vitamin D for a daily intake of 1,500-2,000 kcal ranges between 300 and 1,600 IU/d (mean ± SD: 32.9 ± 8.5 mg/100 kcal) in the complete formulas for enteral nutrition most commonly used. 50% of the diets studied, for an intake of 2,000 kcal/d, and 90% for an intake of 1,500 kcal/d, provide less than 600 IU/d of vitamin D. Discussion: Some revised recently guidelines published recommendations of daily intake of vitamin D. The document published by the U.S. Institute of Medicine recommended for adults between 19 and 70 years, 600 IU/d and up from 70, proposes 800 IU/d of vitamin D. These amounts are deemed insufficient by other scientific societies to state that to achieve blood levels of 25 (OH) D equal or greater than 30 ng/ml may be required a daily intake of 1,500-2,000 IU and a number two or three times higher if previous deficiency exists. Conclusions: Further controlled studies are needed to ascertain which is the appropriate dose of vitamin D in advanced stages of neurological disease, where sun exposure is difficult and unlikely. We suggest that the vitamin D content should probably be reconsidered in enteral nutrition formulas, which, in light of recent publications appear as clearly insufficient for standard energy intakes (1,500-2,000 kcal). [ABSTRACT FROM AUTHOR]

Introduction: Vitamin D deficiency produces inadequate bone mineralization, proximal muscle weakness, abnormal gait and increased risk of falls and fractures. Moreover, in epidemiological studies, has been associated with increased risk of cancer, autoimmune diseases, type 1 and 2 diabetes, rheumatoid arthritis, multiple sclerosis, infectious diseases, cardiovascular diseases and depression. When synthesis through the skin by sun exposure is not possible and the patient can not eat by mouth, as in the advanced stages of various neurological diseases, the supply of vitamin D has to be done by enteral nutrition. Objectives: The aim of this study is to review the role of vitamin D in a common group of neurological conditions that often require artificial nutrition and analyze whether the vitamin D of different enteral nutrition formulas is adequate to meet the needs of this group of patients. Results: Numerous studies have shown the association between vitamin D deficiency and increased incidence of dementia, stroke and other neurodegenerative diseases. Interventions aimed to increase levels of vit D and its effects on functional (falls, pain, quality of life) and cardiovascular goals (cardiovascular death, stroke, myocardial infarction, cardiovascular risk factors) have obtained as highlight data a clear reduction of falls and fractures, while the evidence for the other parameters studied is still limited and inconsistent. The content of calcium and vitamin D of enteral formulas is legislated in our country. The total amount of vitamin D for a daily intake of 1,500-2,000 kcal ranges between 300 and 1,600 IU/d (mean ± SD: 32.9 ± 8.5 mg/100 kcal) in the complete formulas for enteral nutrition most commonly used. 50% of the diets studied, for an intake of 2,000 kcal/d, and 90% for an intake of 1,500 kcal/d, provide less than 600 IU/d of vitamin D. Discussion: Some revised recently guidelines published recommendations of daily intake of vitamin D. The document published by the U.S. Institute of Medicine recommended for adults between 19 and 70 years, 600 IU/d and up from 70, proposes 800 IU/d of vitamin D. These amounts are deemed insufficient by other scientific societies to state that to achieve blood levels of 25 (OH) D equal or greater than 30 ng/ml may be required a daily intake of 1,500-2,000 IU and a number two or three times higher if previous deficiency exists. Conclusions: Further controlled studies are needed to ascertain which is the appropriate dose of vitamin D in advanced stages of neurological disease, where sun exposure is difficult and unlikely. We suggest that the vitamin D content should probably be reconsidered in enteral nutrition formulas, which, in light of recent publications appear as clearly insufficient for standard energy intakes (1,500-2,000 kcal). [ABSTRACT FROM AUTHOR]

Aim: To analyse the calcium contribution of one unit of fermented milk enriched with calcium and vitamin D in the daily calcium intake for postmenopausal women. Subjects: 261 postmenopausal women. Methods: 28 day duration of exploratory, nutritional trial. All subjects received dietary advice on how to increase calcium intake in the daily diet and exercise recommendations with a unit of a fermented milk enriched with calcium and vitamin D (Densia®) which was consumed daily for the 28 day duration trial. A dietary assessment was used to evaluate dietary intake of calcium at the beginning and at the end of the trial. Results: The average amount of calcium intake in milligrams was higher at the end of the trial versus the average intake at the beginning of the trial. The number of women who achieved the calcium recommendation intake for their ages increased at the end of the trial. Conclusions: Dietetic methods and the daily consumption of a unit of fermented milk enriched with calcium and vitamin D increases the average daily dietetic contribution of calcium. However, a percentage of the subjects still presented a daily calcium intake below the dietary recommendations, suggesting the need to adopt more intense strategies to help increase daily recommended calcium intake. [ABSTRACT FROM AUTHOR]

Introduction: Vitamin D deficiency is known to be very common in adolescent girls and elderly women. Aim: To analyze vitamin D status, vitamin D intake and solar exposure of Spanish participants in The Five Countries Study of Optiford Project. Methods: Questionnaires approved and validated of lifestyle and food consumption frequency applied. The biochemical analysis of 25-hidroxivitamin D and PTH and the evaluation of the solar exposure (dosymeter UV VioSpor) were carried out. Results: The average solar exposure of adolescent girls (1,519 J/m2) was double than elderly women (740 J/m2). The vitamin D status of adolescent girls in summer and winter was better than elderly women. Conclusions: Solar exposure habits are different between the two age groups. This fact, jointly to the lower body's capacity to synthesize Vitamin D through exposure to the sun in the elderly, may justify the worse vitamin D status in this age group. [ABSTRACT FROM AUTHOR]

Introduction: Vitamin D defficiency is a big public health concern, especially among women. For this reason, "The Five Countries Study" was set up whithin the OPTIFORD project. This study aims at knowing the vitamin D status in adolescent and older women in five European countries according to their different dietary and behavioral habits. Objectives: To analyze the relative contribution of sun exposure and the diet to the vitamin D status among 47 Spanish adolescents participating in " The Five Countries Study". Methods: Validated and standardized questionnaires (health, lifestyle, sun exposure, and frequency of food consumption), biochemical analysis (25-hydroxyvitamin D (S-25-OHD) and parathormone), and assessment of sun exposure (UV dosimeter). Results: Serum levels of S-25-OHD were higher durign the summertime than in winter (61.55 ± 12.85 nmol/l and 45.81 ± 9.29 nmol/l, respectively). Fourtyfive percent of the sample had a worsening of their vitamin status in the winter, as compared with the summer (p < 0.0001). During the summer, vitamin D insufficiency (S-25-OHD ≤ 50 nmol/l) affected 17% of the population, going up to 63% in the winter. Sixtysix percent of the sample did not reach the IR of vitamin D (5 g/day), being the fish the main dietary source of vitamin D. Conclusions: Only 34% of the participants had an adequate vitamin D status. Both adequate sun exposure and vitamin D dietary intake are recommended in order to correct defficient and insufficient situations. [ABSTRACT FROM AUTHOR]

Vitamin D deficiency represents an important public health problem, especially among elderly people, by increasing the morbimortality. Because of the importance of this, in the year 2001 the "Five Countries Study" was put in place, within the European OPTIFORD project (Towards a strategy for optimal vitamin D fortification). This cross-sectional and observational study aims at knowing the vitamin D status in adolescent and elder women from five European countries, including Spain, according to different dietary and behavioral habits. Objective: This work analyzes the relative contribution of sun exposure and diet to the vitamin D status in 53 Caucasian Spanish elder women (72 ± 1.6 years), with an autonomous life, participating at the Five Countries Study. Methodology: The information was gathered in summer and winter time, by using homologated and validated questionnaires: health status and life style questionnaire; assessment of sun exposure by a standardized test and using a Viospor UV dosimeter (only in summer time); biochemical analysis of 25 hydroxyvitamin D (S-25- OHD) and parathyroid hormone; and questionnaire of frequency of selective intake. Results: We observed a direct relationship between sun exposure measured with the dosimeter (741 ± 624 J/m2) and the number of hours outdoors during the measuring week (3.4 ± 1.9 hours/day) (p < 0.0001). The serum levels of S-25-OHD were higher in summer time than during the winter (40.32 ± 20.39 nmol/L and 30.08 ± 17.39 nmol/L, respectively), and 40% of the participants had worse vitamin status in winter as compared with summer time (p < 0.001). During the summer time, vitamin D deficiency (S-25-OHD ≤ 25 nmol/L) affected 28% of the population, being virtually twice as much during the winter time. The higher the sun exposure, as assessed by the dosimeter, the higher the value of S-25-OHD, with clear differences between participants in the S-25-OHD ≤ 25 nmol/L group and those in the S-25-OHD > 50 nmol/L (p = 0.01). There is also a direct association between the number of hours outdoors and S-25-OHD (p = 0.09), with differences between the participants in the S-25-OHD ≤ 25 nmol/L group and the S-25-OHD > 50 nmol/L group. In more than 95% of the sample, mean dietary intakes of vitamin D (5.17 ± 4.84 μg/day in summer time and 4.70 ± 4.72 μg/day in winter time), the main source of which being fish, did not cover the Recommended Allowances. We did not observe a relationship between the dietary intake and blood levels of vitamin D. By contrast, those participants taking vitamin D supplements presented higher S-25-OHD levels (summer = 69.64 nmol/L and winter = 55 nmol/L) than those not consuming it (summer = 36.83 nmol/L and winter = 25.82 nmol/L) (psummer = 0.0003 and p winter < 0.001). Conclusions: The deficient status of vitamin D among the elderly female population has to be corrected, whenever possible, with appropriate sun exposure and an increase in vitamin D intake through the diet, assessing at each particular case the benefits of pharmacological supplementation. [ABSTRACT FROM AUTHOR]

Introduction: [ABSTRACT FROM AUTHOR]

The association between vitamin D deficiency and increased risk of, among others, cardiovascular and autoimmune diseases has lead in the last years to an enhanced interest in the usage of supplements to achieve the normalization of plasmatic values at 25(OH) D. Apparently this search for normalization is resulting in an higher incidence on vitamin D intoxication. We present the case of an 81 years old woman with metabolic encephalopathy and renal failure secondary to iatrogenic vitamin D intoxication. Calcium and vitamin D oral supplements were prescribed after an osteoporotic vertebral fracture. The patient improved clinically as well as analytically after receiving treatment with diuretics and hydration. We emphasize the importance of discarding hypercalcemia as a cause of metabolic encephalopathy; moreover we highly recommend keeping vitamin D intoxication in mind as an uncommon although always possible etiology of reversible hypercalcemia and renal failure. [ABSTRACT FROM AUTHOR]

El artículo considera una revisión del World Cancer Research Fund de un estudio sobre la influencia de la actividad física en la prevención del cáncer colorrectal. El autor también examina la evidencia de una dieta llena de fibra y otras vitaminas como folato y vitamina D en la prevención. Se analiza el impacto de varias comidas que elevan el riesgo del cáncer, como las carnes rojas y los embutidos, según el autor.