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Your search keyword '"Chun, Byoung-Kwon"' showing total 3 results
Start Over Author "Chun, Byoung-Kwon" Topic nucleoside Journal nucleosides, nucleotides & nucleic acids
3 results on '"Chun, Byoung-Kwon"'

1. Synthesis and Biological Activity of 5′,9-Anhydro-3-Purine-ISONucleosides as Potential Anti-Hepatitis C Virus Agents.

Author

Chun, Byoung-Kwon, Wang, Peiyuan, Hassan, Abdalla, Du, Jinfa, Tharnish, PhillipM., Murakami, Eisuke, Stuyver, Lieven, Otto, MichaelJ., Schinazi, RaymondF., and Watanabe, KyoichiA.

Subjects
*INSULIN derivatives, *HEPATITIS C virus, *PURINES, *CELL-mediated cytotoxicity, *HEPATITIS viruses
Abstract

In order to study structure-activity relationships among the derivatives and congeners of 5′,9-anhydro-3-(β-D-ribofuranosyl)xanthine for anti-hepatitis C virus activity, a series of 5′,9-anhydro-purine-isonucleosides with a substituent (s) at 6- or/and 8-position of the purine moiety were synthesized, and their anti-hepatitis C virus activity and cytotoxicity were evaluated and discussed. [ABSTRACT FROM AUTHOR]

Published
2007
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2. Unusual Olefin Formation by PhSe-F trans -Elimination.

Author

Du, Jinfa, Shi, Junxing, Chun, Byoung-Kwon, Hobbs, Ann, Hollecker, Laurent, and Watanabe, KyoichiA.

Subjects
NUCLEOSIDES, NUCLEOTIDES, ALKENES, HIV, NUCLEIC acids
Abstract

A new approach to the synthesis of 2′,3′-didehydro-2′,3′-dideoxynucleosides was described in excellent yield through unusual olefin formation by PhSe-F trans -elimination. [ABSTRACT FROM AUTHOR]

Published
2005
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3. N4-HYDR0XYCYT0SINE DtOXOLANE NUCLEOSIDES AND THEIR ACTIVITY AGAINST HEPATITIS B VIRUS.

Author

Du, Jinfa, Hollecker, Laurent, Shi, Junxing, Chun, Byoung-Kwon, Watanabe, KyoichiA., Schinazi, RaymondF., Nachman, TammyY., Lostia, Stefania, Stuyver, LievenJ., and Otto, MichaelJ.

Subjects
DIOXOLANES, HETEROCYCLIC compounds, NUCLEOSIDES, NUCLEOTIDES, HEPATITIS B virus
Abstract

Novel racemic, D- and L-β-dioxolane N4 -hydroxycylosine nucleosides have been synthesized and evaluated for their activity against hepatitis B virus. None of the synthesized nucleosides demonstrated selective anti-HBV activity. [ABSTRACT FROM AUTHOR]

Published
2005
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