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1. Synthesis of site-specifically modified oligoribonucleotides for studies of the recognition of TAR RNA by HIV-1 tat protein and studies of hammerhead ribozymes.

Author

Slim G, Pritchard C, Biala E, Asseline U, and Gait MJ

Subjects
Base Sequence, Indicators and Reagents, Molecular Sequence Data, Nucleic Acid Conformation, RNA, Catalytic chemistry, tat Gene Products, Human Immunodeficiency Virus, Gene Products, tat metabolism, HIV-1 metabolism, Oligoribonucleotides chemical synthesis, RNA, Catalytic metabolism, RNA-Binding Proteins metabolism, Uracil analogs & derivatives
Abstract

Synthetic oligoribonucleotides having single uracil residues replaced by dU, dT, 2'-O-methylU or 5-bromodU have been prepared and used in the study of the interaction of HIV-1 tat protein with an RNA stem-loop. The preparation of phosphoramidites of 5-bromouridine and purine riboside suitable for use in solid-phase oligoribonucleotide synthesis is also described. The effect of adenine replacement by purine in a hammerhead ribozyme has also been determined.

Published
1991

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