1. Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death
- Author
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Bing Su, Li Lan, Ying Gao, Yang Liu, Luxi Sun, Justin LaFace, Arthur S. Levine, Yanchun Xiao, Jianquan Xu, Carola A. Neumann, Myriam A. Attar, Guo Min Li, Rong Tan, and Satoshi Nakajima
- Subjects
Senescence ,Guanine ,DNA Repair ,Heterochromatin ,DNA repair ,DNA damage ,Green Fluorescent Proteins ,Biology ,Genome Integrity, Repair and Replication ,Cell Line ,03 medical and health sciences ,0302 clinical medicine ,Genetics ,Humans ,Telomeric Repeat Binding Protein 1 ,Cellular Senescence ,Telomere Shortening ,030304 developmental biology ,Repetitive Sequences, Nucleic Acid ,Telomere-binding protein ,0303 health sciences ,Cell Death ,Telomere ,Molecular biology ,Cell biology ,Oxidative Stress ,030220 oncology & carcinogenesis ,Cell aging ,DNA Damage - Abstract
Cellular DNA is organized into chromosomes and capped by a unique nucleoprotein structure, the telomere. Both oxidative stress and telomere shortening/dysfunction cause aging-related degenerative pathologies and increase cancer risk. However, a direct connection between oxidative damage to telomeric DNA, comprising
- Published
- 2015