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164 results on '"FDG‐PET scan"'

17. Predictability of preoperative 18F-FDG PET for histopathological differentiation and early recurrence of primary malignant intrahepatic tumors

Author

Song, Jeong-Yeop, Lee, Yun Nah, Kim, Young Seok, Kim, Sang Gyune, Jin, Soo Ji, Park, Jung Mi, Choi, Gyu Seong, Chung, Jun Chul, Lee, Min Hee, Cho, Youn Hee, Choi, Moon Han, Kim, Dong Choon, Choi, Hyun Jong, Moon, Jong Ho, Lee, Se Hwan, Jeong, Seung Won, Jang, Jae Young, Kim, Hong Soo, and Kim, Boo Sung

Published
2015
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24. Prognostic value of initial fluorodeoxyglucose-PET in esophageal cancer a prospective study

Author

Rest, Catherine Cheze-Le, Metges, Jean-Philippe, Teyton, Pierre, Tallec, Véronique Jestin-Le, Lozac'h, P., Volant, A., and Visvikis, D.

Abstract

Esophageal cancer outcome greatly depends on the pathological stage. Our objectives were to assess prognosis on the basis of the initial fluorodeoxyglucose (FDG)-PET scan, focusing on the correlation between overall survival and FDG uptake in the primary, as well as the presence of FDG-positive lymph nodes or distant metastases.

Published
2008
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25. Significance of incidental fluorodeoxyglucose uptake in the parotid glands and its impact on patient management

Author

Basu, Sandip, Houseni, Mohamed, and Alavi, Abass

Abstract

Minimal-to-low grade fluorodeoxyglucose (FDG) uptake in the parotid glands is regarded as a normal variant in a whole-body survey with FDG-PET. Not frequently, however, a relatively intense or asymmetric FDG uptake is encountered in the parotid glands. The aim of this study was to determine the causes and characteristics of this ‘FDG accumulation of uncertain significance’ in the parotid glands in patients without any known or suspected pathologies at the time of whole-body FDG-PET. In addition, we also examined patients in whom there was no documented evidence of parotid pathology before FDG-PET scan and a suspicion of disease involvement was first raised in the reports in view of focal uptake in the FDG-PET images.

Published
2008
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26. Can FDG PET be used to successfully direct preoperative biopsy of soft tissue tumours?

Author

HAIN, S F, O'DOHERTY, M J., BINGHAM, J, CHINYAMA, C, and SMITH, M A.

Abstract

Magnetic resonance imaging (MRI) has been the most useful tool in the anatomical definition of soft tissue sarcoma, although there remains the problem of defining the lesions as benign or malignant. The management of such lesions requires biopsy prior to surgical resection. If the most malignant area could be defined more accurately, then this area could be targeted for biopsy. Fluorodeoxyglucose positron emission tomography (FDG PET) has been found to be useful in identifying malignancy and variations in grade in soft tissue masses. The aim of this study was to assess the use of FDG PET scanning with or without co-registered MRI to indicate the most appropriate biopsy site. Twenty consecutive patients presented with soft tissue masses with clinical signs of malignancy. All patients underwent MRI and FDG PET scanning and the two images were co-registered. A biopsy site that was the most likely to be malignant was defined on the PET scan. All patients underwent an initial biopsy and then complete surgical resection of the mass. The histological results from the mass were compared with those from the biopsy specimen obtained from the site suggested by the PET scan. In malignant masses the biopsy site suggested by the FDG PET scan was found to be representative of the most malignant site on the whole mass histology. Benign lesions had low or no FDG uptake. In no case did the co-registered image add significantly to the appropriate biopsy site. FDG PET can be used to appropriately direct biopsy in soft tissue sarcoma and potentially may lead to computed tomographyMRI directed outpatient biopsy prior to definitive treatment.

Published
2003

27. Tumour detectability in 2-dimensional and 3-dimensional positron emission tomography using the SET-2400W a phantom study

Author

ZHANG, H., INOUE, T., ALYAFEI, S., TIAN, M., ORIUCHI, N., and ENDO, K.

Abstract

The purpose of this study was to investigate the detectability of small hot lesions in 2-dimensional transmissionemission (2D TE), 2-dimensional simultaneous transmissionemission (2D simultaneous TE) and 3-dimensional transmissionemission (3D TE) acquisition modes in an 18F-fluorodeoxyglucose positron emission tomography (FDG PET) scan. The correlation between target detectability, target size, target to non-target uptake ratio (TN ratio), and standardized uptake value (SUV) were studied. Small hot lesions ranging from 4.4 mm to 36.9 mm in diameter were set in a cylindrical phantom. The images of phantoms with TN ratios of 2.0, 4.0, 6.0, 8.0, 9.6, 13.2, 17.5, 23.8 and 30.3 were obtained in 2D TE, 2D simultaneous TE and 3D TE scans. Tumour uptake of 2-18Ffluoro-2-deoxy-d-glucose (FDG) in a rabbit bearing VX-2 tumours was also studied in 2D TE, 2D simultaneous TE and 3D TE scans. The target with a diameter >10.6 mm and an actual TN ratio from 6.0 to 30.3 could be identified on the images obtained with all the 2D TE, 2D simultaneous TE and 3D TE acquisition modes. The detectability efficiency of a small hot target was found to be 77.8 in 2D TE and 3D TE, but 75.9 in 2D simultaneous TE. The TN ratio and recovery coefficient (RC) of the target from the 2D simultaneous TE image was very similar to that from 2D TE, and the SUV of the target from the 2D TE image was almost the same as that from the 2D simultaneous TE and 3D TE images. This study indicated that 2D simultaneous TE scanning and 3D TE had similar abilities for detecting the tumour as did 2D TE scanning. 2D TE, 2D simultaneous TE and 3D TE scanning had the same feasibility for semi-quantitative analysis using SUV, as well as using the TN ratios for 2D TE and 2D simultaneous TE. In contrast, the use of the TN ratio in 3D TE scanning gave an inferior result in semi-quantative analysis, although there might have been an improvement if a scatter correction had been performed.

Published
2001

29. The diagnostic performance of 18 fluorine-fluorodeoxyglucose PET for brain metastases: a systematic review and meta-analysis.

Author

Chan TK, Li WI, Lau JHY, Chu KS, Au Yong TK, and Kung BT

Subjects
Humans, Fluorine, Positron-Emission Tomography, Brain, Sensitivity and Specificity, Radiopharmaceuticals, Positron Emission Tomography Computed Tomography methods, Fluorodeoxyglucose F18, Brain Neoplasms diagnostic imaging
Abstract

Introduction: Brain metastases may manifest as hypermetabolism or hypometabolism compared with normal brain activity on 18 fluorine-fluorodeoxyglucose PET ( 18 F-FDG PET). We aim to undertake a systematic review and meta-analysis to determine the diagnostic accuracy of FDG PET for detecting brain metastases from different extracranial primary cancers., Methods: PubMed and EMBASE were searched systematically. Study selection and quality assessment were performed independently by two authors. Meta-analysis was performed using a bivariate random-effects model. Subgroup analysis and meta-regression would be performed if heterogeneity was found., Results: A total of 2227 patients from 11 studies were included in the review and analysis. Using the bivariate random-effects model, summary patient-based sensitivity and specificity for all 11 studies were estimated to be 0.440 [95% confidence interval (CI)] 0.295-0.597) and 0.997 (95% CI, 0.977-1.000). In view of significant between-study heterogeneity ( I2  = 74.0% for sensitivity and I2  = 67.3% for specificity), subgroup analyses were performed. Meta-regression showed significantly higher patient-based summary sensitivity for the three better-quality studies (a total of 1037 patients) with satisfactory index test (counting both hypermetabolism and hypometabolism as positive index test) and satisfactory reference standards (other imaging and clinical follow-up) compared with other included studies [0.735 (95% CI, 0.601-0.836) vs 0.304 (95% CI, 0.223-0.400), P value = 0.000]., Conclusion: Our systematic review and meta-analysis showed that FDG PET has overall limited sensitivity and excellent specificity in the detection of brain metastases from extracranial primary cancers. Importantly, subgroup analyses showed that the sensitivity can be significantly improved by raising awareness of asymmetrical hypometabolism. Further studies are warranted to assess the benefits of including the brain in FDG PET studies for all or certain groups of oncological patients., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2023
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40. Atherosclerotic 18F-FDG and MDP uptake in femoral arteries, changes with age

Author

Domenico Rubello, Abass Alavi, Drew A. Torigian, and Gonca Bural

Subjects
Adult, Male, Aging, Metabolic Clearance Rate, Whole body imaging, Femoral artery, 030204 cardiovascular system & hematology, Technetium Tc 99m Medronate, Bone scans, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Age groups, Fluorodeoxyglucose F18, medicine.artery, medicine, Retrospective analysis, Humans, Radiology, Nuclear Medicine and imaging, Whole Body Imaging, Patient group, Aged, Fluorodeoxyglucose, Aged, 80 and over, business.industry, General Medicine, Middle Aged, medicine.disease, Atherosclerosis, Femoral Artery, Disease Progression, Female, Radiopharmaceuticals, business, Nuclear medicine, medicine.drug, Calcification
Abstract

OBJECTIVES This study was carried out to evaluate the atherosclerotic changes that occur with age in the femoral arteries. To this end, a group of patients were investigated both by a fluorine-18 fluorodeoxyglucose (F-FDG) PET scan and by a whole-body bone scan. METHODS We included 38 patients (25 women, 13 men, age range: 25-84 years) in this retrospective analysis. All patients underwent an F-FDG PET scan and a Tc-MDP bone scan. The mean interval time between the bone scans and F-FDG PET scans was 1.2±1.6 months. Patients randomly underwent the bone scan or the PET scan first. The patients were subdivided into four groups, with the following age ranges: 25-50, 51-60, 61-70, and 71-84 years. Regions of interest were drawn both over the femoral arteries and the adjacent background (BKG) both on F-FDG PET examinations and MDP bone scans, and the uptake values were calculated. Finally, we calculated and compared the uptake ratios of F-FDG/BKG and MDP/BKG in the four age groups. These ratios were obtained in the exact same way using equal regions of interest and equal drawing positions. RESULTS The uptake ratios of F-FDG/BKG in the femoral arteries increased with age in the four age groups (P

Published
2016

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