1. Gene manipulation to enhance MIBG-targeted radionuclide therapy.
- Author
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Mairs RJ, Fullerton NE, Cosimo E, and Boyd M
- Subjects
- Animals, Drug Delivery Systems methods, Humans, Radiopharmaceuticals therapeutic use, 3-Iodobenzylguanidine therapeutic use, Gene Targeting methods, Genetic Therapy methods, Neuroblastoma genetics, Neuroblastoma radiotherapy, Norepinephrine Plasma Membrane Transport Proteins genetics, Radiotherapy methods
- Abstract
The goal of targeted radionuclide therapy is the deposition in malignant cells of sterilizing doses of radiation without damaging normal tissue. The radiopharmaceutical [(131)I]meta-iodobenzylguanidine ([(131)I]MIBG) is an effective single agent for the treatment of neuroblastoma. However, uptake of the drug in malignant sites is insufficient to cure disease. A growing body of experimental evidence indicates exciting possibilities for the integration of gene transfer with [(131)I]MIBG-targeted radiotherapy.
- Published
- 2005
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