In this research, curium oxide (CmO2) is studied as fuel for VVER-1200 reactor to get an attention to its energy value and possibilities. For this purpose, CmO2 is used in fuel rods or integrated burnable absorber (IBA) rods with and without UO2 and then compared with the conventional fuel assembly of VVER-1200 reactor. It is burned to 60 GWd/t by using SRAC-2006 code and JENDL-4.0 data library. From these studies, it is found that CmO2 is competent like UO2 as a fuel due to higher fission cross-section of 243Cm and 245Cm isotopes and neutron capture cross-section of 244Cm and 246Cm isotopes. As a result, when some or all of the UO2 of fuel rods or IBA rods are replaced by CmO2, we get a similar k-inf like the reference even with lower enrichment UO2 fuels. These studies show that the use of CmO2 as IBA rods is more effective than the fuel rods considering the initially loaded amount, power peaking factor (PPF), fuel temperature and void coefficient, and the quality of spent fuel. From a detailed study, 3% CmO2 with inert material ZrO2 in IBA rods are recommended for the VVER-1200 reactor assembly from the once through concept.