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Start Over Author "Sun YBY" Journal npj regenerative medicine

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1. Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential.

Author

Nefzger CM, Jardé T, Srivastava A, Schroeder J, Rossello FJ, Horvay K, Prasko M, Paynter JM, Chen J, Weng CF, Sun YBY, Liu X, Chan E, Deshpande N, Chen X, Li YJ, Pflueger J, Engel RM, Knaupp AS, Tsyganov K, Nilsson SK, Lister R, Rackham OJL, Abud HE, and Polo JM

Abstract

The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming algorithm, we identified a set of key transcription factors (Egr1, Irf1, FosB) that drives molecular and functional differences between old and young states. Overall, by dissecting the molecular signature of aged ISCs, our study identified transcription factors that enhance the regenerative capacity of ISCs., (© 2022. The Author(s).)

Published
2022
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