1. Dynamic instability and oscillations of microtubules.
- Author
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Araki, H., Brézin, E., Ehlers, J., Frisch, U., Hepp, K., Jaffe, R. L., Kippenhahn, R., Weidenmüller, H. A., Wess, J., Zittartz, J., Beiglböck, W., Lehr, Sabine, Parisi, Jürgen, Müller, Stefan C., Zimmermann, Walter, Marx, Alexander, and Mandelkow, Eckhard
- Abstract
Microtubules, dynamic protein fibers of eukaryotic cells, can be formed by in vitro polymerization in aqueous solutions of the constituent protein tubulin. The kinetics of microtubule self-assembly can be studied by light or X-ray scattering and by video-enhanced light microscopy. While the first method records ensemble averages of microtubules, the latter allows observation of single microtubules. At conditions of overall microtubule formation, microtubules switch stochastically between phases of growth and phases of rapid shortening ("dynamic instability"). At high tubulin concentrations, length-excursions of the microtubules can be correlated, resulting in synchronous changes of microtubule assembly in time and space (oscillations, spatial patterns). First, a short review of the structure and biological functions of microtubules will be presented. Then, the dynamics of individual microtubules and collective phenomena in ensembles of large numbers of microtubules will be discussed. [ABSTRACT FROM AUTHOR]
- Published
- 1997
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