1. Blood-spinal cord barrier permeability in experimental spinal cord injury: dynamic contrast-enhanced MRI
- Author
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Shi Jie Liu, Pallavi Ahobila-Vajjula, David M. Cohen, Ponnada A. Narayana, Chirag B. Patel, Tessy Chacko, and Laura M. Sundberg
- Subjects
Pathology ,medicine.medical_specialty ,Cord ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Blood–brain barrier ,medicine.disease ,Spinal cord ,medicine.anatomical_structure ,Traumatic injury ,Permeability (electromagnetism) ,Dynamic contrast-enhanced MRI ,medicine ,Molecular Medicine ,Radiology, Nuclear Medicine and imaging ,skin and connective tissue diseases ,business ,Spinal cord injury ,Spectroscopy - Abstract
After a primary traumatic injury, spinal cord tissue undergoes a series of pathobiological changes, including compromised blood-spinal cord barrier (BSCB) integrity. These vascular changes occur over both time and space. In an experimental model of spinal cord injury (SCI), longitudinal dynamic contrast-enhanced MRI (DCE-MRI) studies were performed up to 56 days after SCI to quantify spatial and temporal changes in the BSCB permeability in tissue that did not show any visible enhancement on the post-contrast MRI (non-enhancing tissue). DCE-MRI data were analyzed using a two-compartment pharmacokinetic model. These studies demonstrate gradual restoration of BSCB with post-SCI time. However, on the basis of DCE-MRI, and confirmed by immunohistochemistry, the BSCB remained compromised even at 56 days after SCI. In addition, open-field locomotion was evaluated using the 21-point Basso-Beattie-Bresnahan scale. A significant correlation between decreased BSCB permeability and improved locomotor recovery was observed.
- Published
- 2008