1. Developmental trajectory of magnetic susceptibility in the healthy rhesus macaque brain
- Author
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Jing Wu, Siyue Peng, Yuhua Zhang, Boyang Pan, Honghua Chen, Xintian Hu, and Nan‐Jie Gong
- Subjects
Brain Mapping ,Iron ,Magnetic Phenomena ,Animals ,Brain ,Molecular Medicine ,Radiology, Nuclear Medicine and imaging ,Macaca mulatta ,Magnetic Resonance Imaging ,Spectroscopy - Abstract
Quantitative susceptibility mapping (QSM) is used to quantify iron deposition in non-human primates in our study. Although QSM has many applications in detecting iron deposits in the human brain, including the distribution of iron deposits in specific brain regions, the change of iron deposition with aging, and the comparison of iron deposits between diseased groups and healthy controls, few studies have applied QSM to non-human primates, while most animal brain experiments focus on biochemical and anatomical results instead of non-invasive experiments. Additionally, brain imaging in children's research is difficult, but can be substituted using young rhesus monkeys, which are very similar to humans, as research animals. Therefore, understanding the relationship between iron deposition and age in rhesus macaques' brains can offer insights into both the developmental trajectory of magnetic susceptibility in the animal model and the correlated evidence in children's research. Twenty-three healthy rhesus macaque monkeys (23 ± 7.85 years, range 2-29 years) were included in this research. Seven regions of interest (ROIs-globus pallidus, substantia nigra, dentate nucleus, caudate nucleus, putamen, thalamus, red nucleus) have been analyzed in terms of QSM and R
- Published
- 2022