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Your search keyword '"H Asakura"' showing total 34 results
Start Over Author "H Asakura" Journal nihon shokakibyo gakkai zasshi the japanese journal of gastro enterology
34 results on '"H Asakura"'

1. [A case of ulcerative colitis with Sweet's syndrome].

Author

Baba Y, Honma T, Takei S, Suzuki K, Arai F, Kobayashi M, Sugimura K, Narisawa R, Takahashi T, Asakura H, Tomiyama K, and Ajioka Y

Subjects
Colitis, Ulcerative pathology, Female, Granulocyte Colony-Stimulating Factor blood, Humans, Middle Aged, Neutrophil Activation physiology, Colitis, Ulcerative complications, Sweet Syndrome etiology
Published
2001

2. [An autopsy case of the diffuse type of cholangiocellular carcinoma associated with extensive portal thrombi and acute hepatic failure].

Author

Uchida M, Takahashi T, Sugiyama M, Takahashi K, Asakura H, Kamura T, and Ajioka Y

Subjects
Aged, Bile Duct Neoplasms pathology, Cholangiocarcinoma pathology, Humans, Male, Thrombosis pathology, Bile Duct Neoplasms complications, Bile Ducts, Intrahepatic, Cholangiocarcinoma complications, Liver Failure, Acute complications, Neoplastic Cells, Circulating pathology, Portal Vein, Thrombosis complications
Published
1998

3. [Immunological effect of immunoglobulin on experimental colitis induced by dextran sulfate].

Author

Shintani N, Nakajima T, Nagai H, Watanabe M, Kagitani Y, Takizawa H, and Asakura H

Subjects
Animals, Colitis chemically induced, Dextran Sulfate, Male, Rats, Rats, Wistar, Colitis immunology, Immunoglobulin G pharmacology
Abstract

To clarify the mechanism of action of immunoglobulin (IgG) in intravenous immunoglobulin therapy for ulcerative colitis (UC) patients, we studied the effect of IgG on the dynamics of immunocompetent cells in the colonic mucosa of experimental colitis induced by dextran sulfate sodium (DSS) in rats. The administration of the same species' IgG suppressed the mucosal infiltration of immunocompetent cells (activated T cells, macrophages and neutrophils), although the different species' IgG didn't. We have already shown that the same species' IgG, suppressed the production of inflammatory cytokines (TNF alpha, IL-1 alpha and IL-8) in the colonic mucosa of experimental colitis induced by DSS. In the present report, we demonstrated the different species' IgG, as well as same species' IgG, suppressed the production of inflammatory cytokines (TNF alpha and IL-1 alpha) from lamina propria mononuclear cells of rat large intestine in vitro. Therefore, it was considered that the suppression of cytokine production was a consequence of the decreased immunocompetent cells in colitis mucosa. Furthermore, we demonstrated that the DSS-treated antigen presenting cells (APCs) activated antigen-specific T cells as a possible mechanism underlying the colitis induced by DSS and the same species' IgG inhibited this activation of T cells.

Published
1995

5. [Effect of gamma-immunoglobulin in experimental colitis induced by dextran sulfate].

Author

Shintani N, Nakajima T, Nakakubo H, Narita Y, Nagai H, Hirao Y, Watanabe M, Yokoyama K, Takizawa H, and Asakura H

Subjects
Animals, Colitis, Ulcerative chemically induced, Colitis, Ulcerative immunology, Cytokines biosynthesis, Dextran Sulfate, Immunoglobulins, Intravenous administration & dosage, Male, Rats, Rats, Wistar, Colitis, Ulcerative therapy, Immunoglobulin gamma-Chains therapeutic use
Abstract

To clarify the mechanisms of action of immunoglobulin (IgG) in intravenous immunoglobulin therapy for the ulcerative colitis (UC) patients, we studied the therapeutic effect of IgG on experimental rat colitis induced by dextran sulfate sodium and on the production of inflammatory cytokines such as TNF alpha, IL-1 alpha and IL-8. The administration of rat IgG demonstrated to suppress the development of blood stool and the induction of the ulcerative lesion in large intestine. The levels of TNF alpha, IL-1 alpha and IL-8 were increased in blood and mucosa of the large intestine in this model. Rat IgG showed a tendency to decrease the levels of the cytokines in colonic mucosa. This result seems to provide a piece of explanation of how massive administration of IgG shows an improvement in the ulcerative lesion of UC patients.

Published
1994

6. [Immunopharmacological therapy of ulcerative colitis].

Author

Asakura H

Subjects
Adjuvants, Immunologic therapeutic use, Antibodies, Monoclonal therapeutic use, Humans, Immunoglobulins, Intravenous administration & dosage, Immunosuppressive Agents therapeutic use, Immunotoxins therapeutic use, Colitis, Ulcerative therapy, Immunotherapy
Published
1993

7. [Clinical significance of antibodies against calmodulin in patients with various liver diseases].

Author

Tsuruya T, Hata K, Kamimura T, Hayakawa A, Aoyagi Y, Asakura H, Ishihara K, Toshima M, Soga K, and Sibasaki K

Subjects
Blotting, Western, Enzyme-Linked Immunosorbent Assay, Hepatitis immunology, Humans, Immunoglobulin M analysis, Liver Neoplasms immunology, Autoantibodies analysis, Calmodulin immunology, Liver Diseases immunology
Abstract

The sera from patients with various liver diseases were investigated for the antibody against calmodulin (CaM) extracted from bovine brain by the enzyme linked immunosorbent assay. The specificity and purity of CaM were confirmed by the Western blot technique using anti-CaM antibody (anti-CaM) positive sera. IgA class antibody was frequently detected in patients with hepatocellular carcinoma (HCC), autoimmune hepatitis (AIH) and chronic active hepatitis (CAH). On the other hand, IgG class antibody was very often present in patients liver cirrhosis, AIH and acute viral hepatitis (AVH). Sixty seven percent of patients with AVH in the acute phase were positive for IgM class anti-CaM and 33% of patients with AVH in the convalescent phase positive respectively. In AVH, the titer of anti-CaM reached its peak on 26.3 days after the onset. The titer of anti-CaM in fulminant hepatitis was higher than that in AVH. Seventy percent of type A hepatitis patients were positive for IgM class anti-CaM, 33% of type B and 33% of type non-A non-B. These results suggest that the frequency and titer of anti-CaM may depend upon the type of hepatitis and the degree of liver cell injury.

Published
1991

11. [A case of ulcerative colitis associated with alkaline phosphatase (ALP)-and lactate dehydrogenase (LDH)-binding immunoglobulins].

Author

Watanabe M, Kitahora T, Aiso S, Yoshida T, Kobayashi K, Hibi T, Asakura H, Thuchiya M, Saga M, and Kano S

Subjects
Adult, Humans, Immunoglobulin kappa-Chains analysis, Immunoglobulin lambda-Chains analysis, Male, Alkaline Phosphatase immunology, Colitis, Ulcerative enzymology, Immunoglobulin A analysis, Immunoglobulin G analysis, Isoenzymes immunology, L-Lactate Dehydrogenase immunology
Published
1984

12. [Case of double cancer of the lung and stomach].

Author

Morita A, Asakura H, Tsuchiya M, Ishii H, and Tamaoki K

Subjects
Aged, Carcinoma, Squamous Cell, Humans, Male, Adenocarcinoma, Lung Neoplasms, Neoplasms, Multiple Primary, Stomach Neoplasms
Published
1975

13. [Two cases of digestive cancer demonstrated remarkable regression by hyperthermia with systemic chemotherapy].

Author

Soga K, Turuya T, Toshima M, Shibasaki K, Matugi H, Kawai C, and Asakura H

Subjects
Adenocarcinoma therapy, Carcinoma, Hepatocellular therapy, Colonic Neoplasms therapy, Combined Modality Therapy, Fluorouracil administration & dosage, Humans, Liver Neoplasms therapy, Male, Middle Aged, Mitomycin, Mitomycins administration & dosage, Remission Induction, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Digestive System Neoplasms therapy, Hyperthermia, Induced
Published
1989

14. [Clinical features and management of 7 cases of toxic megacolon].

Author

Tsuchiya M, Kobayashi K, Aiso S, Watanabe M, Yoshida T, Ishikawa M, Yoshioka M, Hamada Y, Asakura H, and Ando K

Subjects
Adolescent, Adult, Female, Humans, Male, Megacolon, Toxic drug therapy, Prednisolone administration & dosage, Sulfasalazine administration & dosage, Colitis, Ulcerative diagnosis, Megacolon, Toxic diagnosis
Published
1983

17. [Effects of mast cell degranulation induced by compound 48/80 on the colonic mucosal microcirculation in the rat and suppressive action of tranilast].

Author

Yonei Y, Oda M, Nakamura M, Tsukada N, Komatsu H, Akaiwa Y, Honda K, Kaneko K, Morishita T, and Asakura H

Subjects
Animals, Blood Volume drug effects, Intestinal Mucosa blood supply, Mast Cells ultrastructure, Microcirculation drug effects, Rats, Rats, Inbred Strains, Colon blood supply, Mast Cells drug effects, ortho-Aminobenzoates pharmacology, p-Methoxy-N-methylphenethylamine pharmacology
Published
1986

21. [Rare case of protein-losing intestinal lymphangiectasia].

Author

Kato S, Asakura H, Miura S, Hamada Y, and Ichikawa E

Subjects
Adult, Colonoscopy, Humans, Lymphangiectasis, Intestinal physiopathology, Lymphangiectasis, Intestinal surgery, Lymphography, Male, Lymphangiectasis, Intestinal pathology, Protein-Losing Enteropathies pathology
Published
1985

25. [Study on fat absorption and plasma fatty acid composition in patients with protein--losing enteropathy from view point of disorders of intestinal lymphatics (author's transl)].

Author

Miura S, Asakura H, Morishita T, Kobayashi K, Morita A, and Tsuchiya M

Subjects
Adolescent, Adult, Aged, Female, Humans, Intestinal Absorption, Malabsorption Syndromes metabolism, Male, Middle Aged, Dietary Fats metabolism, Fatty Acids blood, Intestinal Diseases metabolism, Lymphatic Diseases metabolism, Protein-Losing Enteropathies metabolism
Published
1981

26. [Study on the fat absorption and transportation into intestinal lymph of rats--differences in the absorption of saturated and unsaturated long chain fatty acids and the role of intestinal alkaline phosphate (author's transl)].

Author

Miura S, Asakura H, Miyairi M, Morishita T, Ishii H, and Tsuchiya M

Subjects
Animals, Biological Transport, Intestine, Small enzymology, Intestines, Male, Rats, Alkaline Phosphatase metabolism, Fatty Acids metabolism, Fatty Acids, Unsaturated metabolism, Intestinal Absorption, Lymph metabolism
Published
1979

29. [Fat absorption and transportation in patients with liver cirrhosis and in CCl4-induced cirrhotic rats (author's transl)].

Author

Miura S, Asakura H, Kobayashi K, Munakata Y, Yoshioka M, Morishita T, and Tsuchiya M

Subjects
Animals, Carbon Tetrachloride Poisoning metabolism, Humans, Intestinal Absorption, Liver Cirrhosis, Experimental chemically induced, Liver Cirrhosis, Experimental metabolism, Male, Rats, Rats, Inbred Strains, Intestine, Small metabolism, Lipid Metabolism, Liver Cirrhosis metabolism
Published
1982

31. [A case of duodenal somatostatinoma and a review of the literature].

Author

Takekawa S, Hagiwara T, Ishii H, Hamada Y, Kobayashi K, Munakata Y, Asakura H, and Tsuchiya M

Subjects
Duodenal Neoplasms pathology, Duodenal Neoplasms physiopathology, Humans, Male, Middle Aged, Somatostatin metabolism, Somatostatinoma pathology, Somatostatinoma physiopathology, Adenoma, Islet Cell diagnosis, Duodenal Neoplasms diagnosis, Somatostatinoma diagnosis
Published
1985

33. [Assessment of elemental diet therapy by rapid turnover transport proteins].

Author

Asakura H, Yoshioka M, Morishita T, Suzuki K, Kitahora T, Shimabukuro K, Muraoka M, Kamegaya K, Watanabe T, and Ookubo T

Subjects
Adult, Aged, Crohn Disease metabolism, Female, Gastrointestinal Neoplasms therapy, Humans, Male, Middle Aged, Crohn Disease therapy, Parenteral Nutrition, Retinol-Binding Proteins metabolism, Serum Albumin metabolism, Transferrin metabolism
Published
1984

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