1. Intensive Diabetes Therapy and Ocular Surgery in Type 1 Diabetes
- Author
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David M. Nathan, John M. Lachin, Lloyd Paul Aiello, Wanjie Sun, Patricia A. Cleary, Sapna Gangaputra, Arup Das, Ronald Klein, and Szilard Kiss
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Cataract Extraction ,Ophthalmologic Surgical Procedures ,Diabetes Therapy ,Cataract ,Article ,law.invention ,Young Adult ,chemistry.chemical_compound ,Randomized controlled trial ,law ,Vitrectomy ,Internal medicine ,Diabetes mellitus ,Epidemiology ,medicine ,Humans ,Hypoglycemic Agents ,Insulin ,Proportional Hazards Models ,Glycated Hemoglobin ,Type 1 diabetes ,Diabetic Retinopathy ,business.industry ,Glaucoma ,General Medicine ,Diabetic retinopathy ,medicine.disease ,Surgery ,Diabetes Mellitus, Type 1 ,chemistry ,Female ,Glycated hemoglobin ,business ,Follow-Up Studies ,Retinopathy - Abstract
BACKGROUND The Diabetes Control and Complications Trial (DCCT) showed a beneficial effect of 6.5 years of intensive glycemic control on retinopathy in patients with type 1 diabetes. METHODS Between 1983 and 1989, a total of 1441 patients with type 1 diabetes in the DCCT were randomly assigned to receive either intensive diabetes therapy or conventional therapy aimed at preventing hyperglycemic symptoms. They were treated and followed until 1993. Subsequently, 1375 of these patients were followed in the observational Epidemiology of Diabetes Interventions and Complications (EDIC) study. The self-reported history of ocular surgical procedures was obtained annually. We evaluated the effect of intensive therapy as compared with conventional therapy on the incidence and cost of ocular surgery during these two studies. RESULTS Over a median follow-up of 23 years, 130 ocular operations were performed in 63 of 711 patients assigned to intensive therapy (8.9%) and 189 ocular operations in 98 of 730 patients assigned to conventional therapy (13.4%) (P
- Published
- 2015