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The article reports that the European Society of Cardiology does not recommend antiplatelet therapy in patients who are free of overt cardiovascular disease. It mentions that the U.S. Preventive Services Task Force recommends initiation of aspirin increases risk of cardiovascular disease. It mentions that the 2019 American College of Cardiology- American Heart Association guideline on primary prevention of cardiovascular disease recommended a more restrictive use of aspirin.

The article presents case study of a 72-year-old white man who was diagnosed with external hemorrhoids. Topics discussed include medications of the patient which involves hydrochlorothiazide and simvastatin; information on use of aspirin on the patient; and an information that asprin is primary prevention of coronary heart disease and stroke.

The article explores the occurrence of prehospital fibrinolysis in patients with acute ST-segment elevation myocardial infarction (STEMI). In the authors' study, they used an open-label, prospective, randomized, parallel-group, multicenter trial that compared the fibrinolytic strategy with primary percutaneous coronary intervention (PCI). They found that 116 of 939 patients saw death from any cause, shock and congestive heart failure among others.