1. Absence of Detectable HIV-1 Viremia after Treatment Cessation in an Infant
- Author
-
Persaud, Deborah, Gay, Hannah, Ziemniak, Carrie, Chen, Ya Hui, Piatak, Michael, Chun, Tae-Wook, Strain, Matthew, Richman, Douglas, and Luzuriaga, Katherine
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Immunology ,Clinical Research ,Infectious Diseases ,Pediatric ,Sexually Transmitted Infections ,HIV/AIDS ,Infection ,Good Health and Well Being ,Anti-Retroviral Agents ,Child ,Preschool ,HIV Antibodies ,HIV Infections ,HIV-1 ,Humans ,Male ,RNA ,Viral ,Viral Load ,Viremia ,Withholding Treatment ,Medical and Health Sciences ,General & Internal Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
An infant born to a woman with human immunodeficiency virus type 1 (HIV-1) infection began receiving antiretroviral therapy (ART) 30 hours after birth owing to high-risk exposure. ART was continued when detection of HIV-1 DNA and RNA on repeat testing met the standard diagnostic criteria for infection. After therapy was discontinued (when the child was 18 months of age), levels of plasma HIV-1 RNA, proviral DNA in peripheral-blood mononuclear cells, and HIV-1 antibodies, as assessed by means of clinical assays, remained undetectable in the child through 30 months of age. This case suggests that very early ART in infants may alter the establishment and long-term persistence of HIV-1 infection.
- Published
- 2013