1. Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level
- Author
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Lazarus, Stephen C, Krishnan, Jerry A, King, Tonya S, Lang, Jason E, Blake, Kathryn V, Covar, Ronina, Lugogo, Njira, Wenzel, Sally, Chinchilli, Vernon M, Mauger, David T, Dyer, Anne-Marie, Boushey, Homer A, Fahy, John V, Woodruff, Prescott G, Bacharier, Leonard B, Cabana, Michael D, Cardet, Juan C, Castro, Mario, Chmiel, James, Denlinger, Loren, DiMango, Emily, Fitzpatrick, Anne M, Gentile, Deborah, Hastie, Annette, Holguin, Fernando, Israel, Elliot, Jackson, Daniel, Kraft, Monica, LaForce, Craig, Lemanske, Robert F, Martinez, Fernando D, Moore, Wendy, Morgan, Wayne J, Moy, James N, Myers, Ross, Peters, Stephen P, Phipatanakul, Wanda, Pongracic, Jacqueline A, Que, Loretta, Ross, Kristie, Smith, Lewis, Szefler, Stanley J, Wechsler, Michael E, and Sorkness, Christine A
- Subjects
Lung ,Clinical Research ,Clinical Trials and Supportive Activities ,Asthma ,6.1 Pharmaceuticals ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Evaluation of treatments and therapeutic interventions ,Respiratory ,Administration ,Inhalation ,Adolescent ,Adult ,Bronchodilator Agents ,Cross-Over Studies ,Double-Blind Method ,Eosinophils ,Female ,Glucocorticoids ,Humans ,Leukocyte Count ,Male ,Medication Adherence ,Middle Aged ,Mometasone Furoate ,Sputum ,Tiotropium Bromide ,Young Adult ,National Heart ,Lung ,and Blood Institute AsthmaNet ,Medical and Health Sciences ,General & Internal Medicine - Abstract
BACKGROUND:In many patients with mild, persistent asthma, the percentage of eosinophils in sputum is less than 2% (low eosinophil level). The appropriate treatment for these patients is unknown. METHODS:In this 42-week, double-blind, crossover trial, we assigned 295 patients who were at least 12 years of age and who had mild, persistent asthma to receive mometasone (an inhaled glucocorticoid), tiotropium (a long-acting muscarinic antagonist), or placebo. The patients were categorized according to the sputum eosinophil level (
- Published
- 2019