1. Ebola Virus Transmission Initiated by Relapse of Systemic Ebola Virus Disease
- Author
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Mbala-Kingebeni, Placide, Pratt, Catherine, Ruffin, Mbusa Mutafali, Pauthner, Matthias G, Bile, Faustin, Ndaye, Antoine Nkuba, Black, Allison, Lusamaki, Eddy Kinganda, Faye, Martin, Aziza, Amuri, Diagne, Moussa M, Mukadi, Daniel, White, Bailey, Hadfield, James, Gangavarapu, Karthik, Bisento, Nella, Kazadi, Donatien, Nsunda, Bibiche, Akonga, Marceline, Tshiani, Olivier, Misasi, John, Ploquin, Aurelie, Epaso, Victor, Paka, Emilia Sana, N’kasar, Yannick Tutu Tshia, Mambu, Fabrice, Edidi, Francois, Matondo, Meris, Bula, Bula, Diallo, Boubacar, Keita, Mory, Belizaire, Marie Roseline Darnycka, Fall, Ibrahima Soce, Yam, Abdoulaye, Sabue, Mulangu, Rimion, Anne W, Salfati, Elias, Torkamani, Ali, Suchard, Marc A, Crozier, Ian, Hensley, Lisa, Rambaut, Andrew, Faye, Ousmane, Sall, Amadou, Sullivan, Nancy J, Bedford, Trevor, Andersen, Kristian G, Wiley, Michael R, Ahuka-Mundeke, Steve, and Tamfum, Jean-Jacques Muyembe
- Subjects
Biodefense ,Vaccine Related ,Prevention ,Infectious Diseases ,Biotechnology ,Rare Diseases ,Emerging Infectious Diseases ,Immunization ,Infection ,Good Health and Well Being ,Adult ,Bayes Theorem ,Democratic Republic of the Congo ,Ebola Vaccines ,Ebolavirus ,Fatal Outcome ,Genome ,Viral ,Hemorrhagic Fever ,Ebola ,Humans ,Male ,Mutation ,Phylogeny ,RNA ,Viral ,Recurrence ,Medical and Health Sciences ,General & Internal Medicine - Abstract
During the 2018-2020 Ebola virus disease (EVD) outbreak in North Kivu province in the Democratic Republic of Congo, EVD was diagnosed in a patient who had received the recombinant vesicular stomatitis virus-based vaccine expressing a ZEBOV glycoprotein (rVSV-ZEBOV) (Merck). His treatment included an Ebola virus (EBOV)-specific monoclonal antibody (mAb114), and he recovered within 14 days. However, 6 months later, he presented again with severe EVD-like illness and EBOV viremia, and he died. We initiated epidemiologic and genomic investigations that showed that the patient had had a relapse of acute EVD that led to a transmission chain resulting in 91 cases across six health zones over 4 months. (Funded by the Bill and Melinda Gates Foundation and others.).
- Published
- 2021