42 results on '"Jeffrey P. Weiss"'
Search Results
2. The patient burden of nocturnal polyuria in the United States: Results from the epidemiology of nocturnal polyuria (EpiNP) study
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Christopher R. Chapple, Matt T. Rosenberg, Elizabeth R. Mueller, Bilal Chughtai, Jeffrey P. Weiss, Kristian Juul, Anne B. Brooks, Elizabeth D. Bacci, Fredrik L. Andersson, Karin S. Coyne, and JLH Ruud Bosch
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Urology ,Neurology (clinical) - Published
- 2023
3. Sleep Disorders, Comorbidities, Actions, Lower Urinary Tract Dysfunction, and Medications ('Sleep C.A.L.M.') in the evaluation and management of nocturia: A simple approach to a complex diagnosis
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Thomas F. Monaghan, Jeffrey P. Weiss, Alan J. Wein, Syed N. Rahman, Jason M. Lazar, Donald L. Bliwise, Karel Everaert, Gary E. Lemack, Jean‐Nicolas Cornu, Marcus J. Drake, Christopher R. Chapple, Hashim Hashim, Jerry G. Blaivas, and Roger R. Dmochowski
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Urology ,Neurology (clinical) - Published
- 2023
4. Polyuria in patients with lower urinary tract symptoms: Prevalence and etiology
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George Z. Fisch, Alexander H. Fang, Connelly D. Miller, Claire Choi, Thomas F. Monaghan, Edward F. Smith, Learta Prishtina, Jeffrey P. Weiss, and Jerry G. Blaivas
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Urology ,Neurology (clinical) - Abstract
Patients with lower urinary tract symptoms (LUTS) can be subcategorized into polyuria, normal or oliguria groups. Polyuria may be caused by pathologies including diabetes mellitus (DM), chronic kidney disease (CKD), diabetes insipidus (DI), or primary polydipsia (PPD). While fluid restriction is appropriate for some, doing so in all may result in serious complications. This study investigates the prevalence of these pathologies in LUTS patients with polyuria.Two databases were retrospectively queried for men and women who filled out a lower urinary tract symptom score (LUTSS) questionnaire, 24-h bladder diary (24HBD) and were polyuric (2.5 L/day). Patients were divided into four groups: poorly controlled DM, DI, an CKD grade 3 and PPD. One-way analysis of variance compared 24HBD and LUTSS questionnaires. Pearson correlation examined LUTSS and bother with 24-h voided volume (24 HVV), maximum voided volume (MVV) and total voids.Among 814 patients who completed a 24HBD, 176 had polyuria (22%). Of the patients with complete data, 7.8% had poorly-controlled DM, 3.1% had DI, 4.7% had CKD grade 3% and 84.4% had PPD. Amongst the four different sub-groups, significant differences were seen in 24 HVV (p 0.001), nocturnal urine volume (NUV) (p 0.001), MVV (p = 0.003), daytime voids (p = 0.05), nocturnal polyuria index (NPi) (p 0.001) and nocturia index (Ni) (p = 0.002). Significance was also seen between LUTSS and bother subscore (r = 0.68, p 0.001), LUTSS and total voids (r = 0.29, p = 0.001) and bother sub-score and total voids (r = 0.21, p = 0.019).22% of patients with LUTS were found to have polyuria based on a 24HBD. Within this cohort, four sub-populations were identified as being demonstrating statistically significant differences in 24 HVV, NUV, MVV, daytime voids, NPi and Ni. Identifying the underlying etiology of polyuria should be carried out to safely treat patients with LUTS.
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- 2022
5. Does traditional pharmacotherapy augment behavioral modification in the treatment of nocturia?
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Jeffrey P. Weiss, Connelly D Miller, Dennis J. Robins, and Thomas F. Monaghan
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medicine.medical_specialty ,030219 obstetrics & reproductive medicine ,business.industry ,Urology ,Urinary system ,030232 urology & nephrology ,Odds ratio ,urologic and male genital diseases ,medicine.disease ,Confidence interval ,03 medical and health sciences ,0302 clinical medicine ,Pharmacotherapy ,Overactive bladder ,Lower urinary tract symptoms ,Interquartile range ,Internal medicine ,medicine ,Nocturia ,Neurology (clinical) ,medicine.symptom ,business - Abstract
Aims To assess the efficacy of traditional first-line non-antidiuretic pharmacotherapy for nocturia in the real-world outpatient urology setting. Methods We retrospectively analyzed voiding diaries from adult men treated for lower urinary tract symptoms (LUTS) at an outpatient urology clinic to identify pairs of voiding diaries with ≥1 nocturnal void at baseline and a corresponding follow-up diary completed within 1 year. We compared the odds of nocturia improvement (decrease of ≥1 nocturnal void) in patients started on LUTS pharmacotherapy versus behavioral modification alone. Results Two hundred and thirteen diary pairs from 93 patients were included. Fifty-seven diary pairs were identified from patients prescribed at least one LUTS drug on the initial visit and 156 diary pairs were identified from patients receiving behavioral modification alone. All standard voiding diary parameters were assessed, and only maximum voided volume differed at baseline (240 ml [interquartile range: 200-330 ml] vs. 280 ml [200-400 ml] with and without pharmacotherapy, respectively, p = 0.04). The odds of nocturia improvement did not significantly differ between pharmacotherapy and behavioral modification treatment groups (crude odds ratio [OR]: 1.16 [95% confidence interval: 0.63-2.16], p = 0.63; maximum voided volume [MVV]-adjusted OR: 1.19 [0.63-2.22], p = 0.59). In contrast, improvement in 24-h urinary frequency was more likely with pharmacotherapy versus behavioral modification alone (crude OR: 2.36 [1.22-4.56], p = 0.01; MVV-adjusted OR: 2.05 [1.05-4.01], p = 0.04). Results were consistent on subgroup analyses restricted to first diary pairs from each patient. Conclusion Despite improvement in 24-h voiding frequency, there was no evidence that adjunctive pharmacotherapy provided a benefit in the treatment of nocturia in men receiving behavioral counseling.
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- 2021
6. Nocturia and electrocardiographic abnormalities among patients at an inner‐city cardiology clinic
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Zhan D. Wu, Pakinam Mekki, Roger R. Dmochowski, Lily Lee, Donald L. Bliwise, Kyle P. Michelson, Fred Gong, Alan J. Wein, Karel Everaert, Christina W. Agudelo, Thomas F. Monaghan, Christopher D George, Jason Lazar, and Jeffrey P. Weiss
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Urology ,030232 urology & nephrology ,urologic and male genital diseases ,Left ventricular hypertrophy ,Electrocardiography ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Diabetes mellitus ,medicine ,Left atrial enlargement ,Humans ,Nocturia ,cardiovascular diseases ,Aged ,Retrospective Studies ,Univariate analysis ,030219 obstetrics & reproductive medicine ,business.industry ,Odds ratio ,Middle Aged ,medicine.disease ,female genital diseases and pregnancy complications ,Cardiovascular Diseases ,Relative risk ,Cardiology ,Female ,Neurology (clinical) ,medicine.symptom ,business ,Body mass index - Abstract
Aims Nocturia has been increasingly recognized as a potential manifestation of cardiovascular disease. However, the relationship between nocturia and electrocardiographic (ECG) abnormalities has not been studied. This study aims to characterize the diagnostic utility of nocturia in identifying left ventricular hypertrophy (LVH), left atrial enlargement (LAE), and prolonged QTc on ECG. Methods Retrospective analysis of nocturnal voiding frequency and contemporaneous ECG data from consecutive patients evaluated at a university-based outpatient cardiology clinic. Three sets of three incremental binary multiple logistic regression models controlling for (1) age, (2) sex and race, and (3) body mass index, hypertension, diabetes mellitus, and diuretic utilization were performed to determine whether nocturia was predictive of LVH, LAE, and prolonged QTc. Results Included patients (n = 143, 77.6% nocturia) were predominantly African-American (89.5%), female (74.1%), and obese (61.5%), of whom 44.1%, 41.3%, and 27.3% had LVH, LAE, and prolonged QTc, respectively. Older age, African-American race, obesity, hypertension, diuretic use, LVH, and LAE were significantly associated with nocturia on univariate analysis. No significant differences were observed in the strength of associations between nocturia and LVH, LAE, or QTc prolongation based on age. Nocturia independently predicted LVH in Models I-III (odds ratios [ORs], 2.99-3.20; relative risks [RRs], 1.18 for all, p ≤ .046) and LAE in Models I-III (ORs, 4.24-4.72; RRs, 1.21 for all, p ≤ .015). No significant associations were observed between nocturia and prolonged QTc. Conclusions Nocturia may be a risk marker for underlying structural cardiac abnormalities.
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- 2020
7. Time of peak nocturnal diuresis rate between men with secondary nocturnal polyuria versus nocturnal polyuria syndrome
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Jeffrey P. Weiss, Zhan D. Wu, Thomas F. Monaghan, Matthew Epstein, Jason Lazar, Arturo Holmes, Alan J. Wein, Karel Everaert, Donald L. Bliwise, Abdo Kabarriti, and Kyle P. Michelson
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Male ,medicine.medical_specialty ,Time Factors ,Urology ,medicine.medical_treatment ,030232 urology & nephrology ,Diuresis ,Nocturnal ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Nocturia ,Renal Insufficiency, Chronic ,Aged ,Retrospective Studies ,Heart Failure ,Sleep Apnea, Obstructive ,030219 obstetrics & reproductive medicine ,Polyuria ,business.industry ,Middle Aged ,medicine.disease ,Circadian Rhythm ,Obstructive sleep apnea ,Heart failure ,Diabetes insipidus ,Cardiology ,Neurology (clinical) ,medicine.symptom ,Diuretic ,business ,Antidiuretic - Abstract
Aim Compare the circadian trajectory of diuresis between nocturnal polyuria (NP) patients with versus without identifiable contributory comorbidities. Methods Retrospective analysis of frequency-volume charts from male patients with clinically-significant nocturia (>= 2 nocturnal voids) and NP (defined by nocturnal urine production [NUP] >= 90 mL/hour or nocturnal polyuria index [NPi] >= 0.33). Patients with NP and chronic kidney disease, congestive heart failure, and/or undertreated obstructive sleep apnea (OSA) were deemed to have secondary NP. Nocturnal polyuria syndrome (NPS) was defined as NP without edema, loop diuretic use, or the aforementioned conditions. Patients with diabetes insipidus or OSA with appropriate continuous positive airway pressure utilization were excluded. The timing and volumes of nocturnal voids were used to derive "early" and "late" nocturnal diuresis rates (mL/hour of urine produced before and after the first nocturnal awakening, respectively). The likelihood of an early peak nocturnal diuresis rate (ie, early >late nocturnal diuresis rate) was compared between patients with NPS versus secondary NP using both a crude and adjusted odds ratio. Results The likelihood of an early peak nocturnal diuresis rate in patients with NPS compared with secondary NP was 2.58 (1.05-6.31) at NUP >= 90 mL/hour and 1.96 (0.87-4.42) at NPi >= 0.33 on crude analysis, and 2.44 (0.96-6.24) and 1.93 (0.83-4.48) after adjustment, respectively. Conclusions A peak early nocturnal diuresis rate was significantly more likely in patients with NPS at NUP >= 90 mL/hour, with similar odds ratios at NPi >= 0.33 and following adjustment. Delineating nocturic patients by NP subgroup may facilitate more individualized management. Patient Summary Many people have to wake up to urinate because they produce too much urine at night-a condition known as "nocturnal polyuria." Nocturnal polyuria might be caused by drinking too much fluid, other behavioral factors, or conditions that make your body hold on to too much fluid, like heart disease, kidney disease, and sleep apnea. In cases of nocturnal polyuria where no clear cause can be identified, it is thought that patients may suffer from a deficiency in nighttime vasopressin, a hormone that plays a key role in how much urine you produce. In this study, we compared the pattern of nighttime urine production in patients with different causes of nocturnal polyuria, which may lead to more personalized treatment options for patients with this condition.
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- 2020
8. Identifying men with global polyuria on a nocturnal‐only voiding diary
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Corey S. Weinstein, Donald L. Bliwise, Christina W. Agudelo, Karel Everaert, Kyle P. Michelson, Connelly D Miller, Thomas F. Monaghan, Jason M. Lazar, Jeffrey P. Weiss, Syed N. Rahman, Tine Kold Olesen, and Joseph G. Verbalis
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Male ,medicine.medical_specialty ,Nocturnal polyuria ,Databases, Factual ,Urine volume ,Urology ,030232 urology & nephrology ,Urination ,Nocturnal ,Mutually exclusive events ,03 medical and health sciences ,0302 clinical medicine ,Lower Urinary Tract Symptoms ,Polyuria ,Humans ,Medicine ,Nocturia ,Sleep period ,Aged ,030219 obstetrics & reproductive medicine ,business.industry ,Middle Aged ,Female ,Neurology (clinical) ,medicine.symptom ,business ,Urine collection - Abstract
Aims Nocturnal polyuria (NP) and global polyuria (GP) are not mutually exclusive. However, by rate, the common criteria for GP (40 mL/kg/24 hours [117 mL/kg/hour in a 70-kg individual] or 3000 mL/24 hours [125 mL/h]) are more stringent than those for NP (90 mL/hour during the sleep period or NP index [NPi; nocturnal volume/24-hour volume] > 0.33 [no minimum rate]). It remains unclear whether total nocturnal urine volume (NUV) may reliably delineate between NP patients with and without comorbid GP. Methods A clinical database of men with lower urinary tract symptoms was searched for voiding diaries completed by patients reporting greater than or equal to 1 nocturnal void(s). Four separate analyses were performed using all combinations of the two NP and two GP criteria listed above. For each analysis, patients were included if they met the criteria for NP, and then stratified by presence or absence of GP (ie, NP + GP vs isolated NP). Results Median NUV was greater among patients with NP + GP for all criteria combinations. Sensitivities greater than or equal to 80%/90%/100% for NP + GP were observed at 1275/1230/1085 mL for {NPi > 0.33 + 24-hour volume > 3000 mL}; 1075/1035/1035 mL for {NPi > 0.33 + 24-hour volume > 40 mL/kg}; 900/745/630 mL for {NUP > 90 mL/hour + 24-hour volume > 3000 mL}; and 1074/1035/990 mL for {NUP > 90 mL/hour + 24-hour volume > 40 mL/kg}. Conclusions An inordinate NUV among men with NP is fairly sensitive for comorbid GP. In the appropriate clinical setting, nocturnal-only diaries may suffice in the evaluation and follow-up of patients with NP, so long as outlying nocturnal volumes prompt a 24-hour diary/urine collection.
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- 2019
9. The modified nocturia index: Refining the workup for nocturia
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Jeffrey P. Weiss, Lauren E. Fink, Jason Lazar, Raymond Khargi, Christina W. Agudelo, Connelly D Miller, Thomas F. Monaghan, Karel Everaert, and Matthew J. Bruha
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medicine.medical_specialty ,Index (economics) ,business.industry ,Urology ,medicine ,Nocturia ,Neurology (clinical) ,medicine.symptom ,business ,Refining (metallurgy) - Published
- 2020
10. Novel immediate/sustained‐release formulation of acetaminophen‐ibuprofen combination (Paxerol®) for severe nocturia associated with overactive bladder: A multi‐center, randomized, double blinded, placebo‐controlled, 4‐arm trial
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Johnathan A. Khusid, Yunzhu Zhao, Lei Xie, Igor Ryndin, King C. Lee, Frank J. Rauscher, Jeffrey P. Weiss, and Jed Kaminesky
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Adult ,Male ,medicine.medical_specialty ,Urology ,030232 urology & nephrology ,Ibuprofen ,Placebo ,03 medical and health sciences ,0302 clinical medicine ,Double-Blind Method ,Original Clinical Article ,medicine ,Humans ,Nocturia ,Adverse effect ,Aged ,Acetaminophen ,Aged, 80 and over ,030219 obstetrics & reproductive medicine ,Urinary Bladder, Overactive ,business.industry ,clinical trial ,Middle Aged ,medicine.disease ,Clinical trial ,Drug Combinations ,Treatment Outcome ,investigational drug ,Tolerability ,Overactive bladder ,Delayed-Action Preparations ,Quality of Life ,Female ,Neurology (clinical) ,medicine.symptom ,Original Clinical Articles ,business ,prostagladin‐E2 inhibitors ,medicine.drug - Abstract
Aim To determine short-term efficacy and safety of Paxerol®, novel immediate:sustained (50%:50%) release tablets containing 325 mg acetaminophen and 150 mg ibuprofen per tablet. Methods One of three dose levels, corresponding to the amounts in 1, 2, and 3 tablets, of Paxerol and placebo were administered for 14 consecutive days to patients with severe nocturia (defined in this study as an average nocturnal voids [NV] ≥2.5) associated with overactive bladder (OAB). Changes in NV, as well as Nocturia Quality of Life (NQOL), duration of first uninterrupted sleep (DFUS), and total hours of nightly sleep (THNS) associated with treatment were assessed. Short-term safety/tolerability was assessed throughout the study and for at least 30 days post-treatment. Results Paxerol at all three doses reduced NV to a greater degree than placebo (average NV -1.1, -1.4, -1.3 voids for low, mid, and high doses, respectively, vs -0.3 void for placebo). NQOL and THNS were similar between baseline and treatment values in all four groups. There were also no between-group differences. Paxerol at high dose tended to (although not statistical significantly) increase DFUS to a greater degree than placebo (1.2 vs 0.4 h, P = 0.057). There were no treatment related adverse events in any of the four groups. Conclusions This study demonstrates short-term efficacy and short-term safety of Paxerol in patients with severe nocturia associated with OAB. The results warrant further investigation of the long-term efficacy and safety of Paxerol in larger patient populations.
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- 2018
11. Can radiation-induced lower urinary tract disease be ameliorated in patients treated for pelvic organ cancer: ICI-RS 2019?
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Jeremy Ockrim, Jeffrey P. Weiss, Ruud Bosch, Amit Bahl, Karen D. McCloskey, Tamsin Greenwell, and Salvador Arlandis
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Oncology ,Male ,medicine.medical_specialty ,Basic science ,Urology ,medicine.medical_treatment ,Urinary system ,brachytherapy ,Urinary Bladder ,030232 urology & nephrology ,Review Article ,Disease ,lower urinary tract fibrosis ,external beam radiation therapy ,03 medical and health sciences ,0302 clinical medicine ,Lower Urinary Tract Symptoms ,Urethra ,Internal medicine ,medicine ,Humans ,Adverse effect ,Radiation Injuries ,Review Articles ,pelvic floor muscle damage ,Pelvic Neoplasms ,030219 obstetrics & reproductive medicine ,business.industry ,Cancer ,medicine.disease ,Radiation therapy ,medicine.anatomical_structure ,hemorrhagic cystitis ,Female ,Neurology (clinical) ,prevention of radiation‐induced LUT complications ,business ,radiation cystitis ,Hemorrhagic cystitis - Abstract
Aims This article reviews the clinical outcomes and basic science related to negative effects of radiotherapy (RT) on the lower urinary tract (LUT) when used to treat pelvic malignancies. Methods The topic was discussed at the 2019 meeting of the International Consultation on Incontinence―Research Society during a “think tank” session and is summarized in the present article. Results RT is associated with adverse effects on the LUT, which may occur during treatment or which can develop over decades posttreatment. Here, we summarize the incidence and extent of clinical symptoms associated with several modes of delivery of RT. RT impact on normal tissues including urethra, bladder, and ureters is discussed, and the underlying biology is examined. We discuss innovative in vivo methodologies to mimic RT in the laboratory and their potential use in the elucidation of mechanisms underlying radiation‐associated pathophysiology. Finally, emerging questions that need to be addressed through further research are proposed. Conclusions We conclude that RT‐induced negative effects on the LUT represent a significant clinical problem. Although this has been reduced with improved methods of delivery to spare normal tissue, we need to (a) discover better approaches to protect normal tissue and (b) develop effective treatments to reverse radiation damage.
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- 2020
12. Is our current understanding and management of nocturia allowing improved care? International Consultation on Incontinence‐Research Society 2018
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Stefan De Wachter, François Hervé, Matthew Epstein, Paul Abrams, Dudley Robinson, Wendy Bower, Andrea Tubaro, Riccardo Lombardo, Alan J. Wein, Karel Everaert, and Jeffrey P. Weiss
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Male ,medicine.medical_specialty ,Nocturnal polyuria ,Hospitalized patients ,Urology ,030232 urology & nephrology ,Bladder capacity ,urologic and male genital diseases ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,Risk Factors ,medicine ,Humans ,Nocturia ,Risk factor ,Intensive care medicine ,Aged ,Quality of Health Care ,Sleep disorder ,030219 obstetrics & reproductive medicine ,business.industry ,medicine.disease ,female genital diseases and pregnancy complications ,Current practice ,Quality of Life ,Female ,Human medicine ,Neurology (clinical) ,medicine.symptom ,Sleep ,business - Abstract
Aims: Nocturia or waking at night, to urinate is a common cause of awakenings and may lead to sleep disturbance, impaired somatic health, impaired quality of life, and increased mortality. The aim of this report is to point out and discuss the aspects and issues that need to be addressed to improve the care of nocturia. Methods: This paper is a report of the presentations and subsequent discussion of a Think Tank session at the annual International Consultation on Incontinence-Research Society (ICI-RS) in June 2018 in Bristol. Results and conclusion: Nocturia is a known risk factor for in-hospital falls. Unfortunately, its assessment in acutely hospitalized (older) people is not the current practice and ward-based care plans are not tailored to this symptom. A new care pathway for hospitalized patients who have nocturia should be considered. More research into the relation of cardiovascular disorders and nocturnal polyuria (NP) is warranted and management of NP patients may be improved by involving a cardiologist in their management. There is definitely a need for phenotyping nocturia in relation to bladder capacity, filling phase, and emptying phase symptoms and how to treat the different phenotypes. In the near future, smart automated monitoring devices and applications might help us to diagnose and treat nocturia with less efforts.
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- 2019
13. Basic or extended urine sampling to analyse urine production?
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An-Sofie Goessaert, Vansh Kapila, Karel Everaert, Jeffrey P. Weiss, and Marie-Astrid Denys
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Adult ,Male ,medicine.medical_specialty ,Pathology ,Urinalysis ,Urology ,030232 urology & nephrology ,Renal function ,Urinary incontinence ,Urine ,Urine collection device ,03 medical and health sciences ,0302 clinical medicine ,Belgium ,Polyuria ,Enuresis ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,Urine Specimen Collection ,medicine.diagnostic_test ,business.industry ,Osmolar Concentration ,Sodium ,Middle Aged ,Circadian Rhythm ,Diuresis ,Urinary Incontinence ,Creatinine ,Female ,Nocturia ,Neurology (clinical) ,medicine.symptom ,business ,Nocturnal Enuresis - Abstract
Background Frequency volume charts are valuable tools to objectify urine production in patients with nocturia, enuresis or nocturnal incontinence. Analyses of daytime and nighttime urine (=basic collection) or analyses of urine samples collected every 3 h (=extended collection) extend this evaluation by describing circadian patterns of water and solute diuresis (=renal function profiles). Aim To assess intra-individual correlation and agreement between renal function profiles provided using basic and extended urine collections, and using two extended urine collections. To create a short-form of the extended collection. Methods This prospective observational study was executed at Ghent University Hospital, Belgium. Study participation was open for anyone visiting the hospital. Participants collected one basic and two extended 24-h urine collections. Urinary levels of osmolality, sodium and creatinine were determined. Results There was a moderate to strong correlation between results of basic and extended urinalyses. Comparing both extended urinalyses showed a moderate correlation between the eight individual samples and a weak to strong correlation between the mean daytime and nighttime values of renal functions. Different samples could be considered as most representative for mean daytime values, while all samples collected between 03 and 05am showed the highest agreement with mean nighttime values of renal function. Conclusion Since there is a good correlation and agreement between basic and extended urine collections to study the mechanisms underlying urine production, the choice of urine sampling method to evaluate urine production depends on the purpose. A nighttime-only urine sample collected between 03 and 05am may be the most practical approach.
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- 2017
14. ICI-RS 2015-Is a better understanding of sleep the key in managing nocturia?
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Jerald Cherian, Marie-Astrid Denys, Karlien Dhondt, Mohammad S. Rahnama'i, Jeffrey P. Weiss, Alan J. Wein, Karel Everaert, Jonathan B. Singer, and Kathleen A. O'Connell
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medicine.medical_specialty ,030219 obstetrics & reproductive medicine ,Nocturnal polyuria ,business.industry ,Urology ,030232 urology & nephrology ,urologic and male genital diseases ,female genital diseases and pregnancy complications ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Treatment modality ,medicine ,Physical therapy ,Nocturia ,Neurology (clinical) ,medicine.symptom ,business - Abstract
Aims Nocturia, or waking up at night to void, is a highly prevalent and bothersome lower urinary tract symptom. However, the applied treatment modalities do not improve symptoms in about half of the patients. The aim of this report is to generate new ideas for future nocturia research, with special emphasis on the role of sleep physiology and sleep disorders. Methods The following is a report of the presentations and subsequent discussion of the Nocturia Think Tank session at the annual meeting of the International Consultation on Incontinence Research Society (ICI-RS), which took place in September 2015 in Bristol. General information about the organization of the ICI-RS meeting can be found on the website "www.ici-rs.org." An overview of challenges within the existing evidence, future research ideas, and results of research with regard to nocturia and sleep were presented. Results and conclusion In order to optimize the management of nocturia and nocturnal polyuria (NP), future research has to focus on the development of unambiguous terminology regarding nocturia and NP, the role of renal function profiles and simplified frequency volume charts as guidance of individualized therapy and the role of sleep disorders such as periodic limb movements during sleep and habitual voiding as a response to awakening. Neurourol. Urodynam. 37:2048-2052, 2018. © 2016 Wiley Periodicals, Inc.
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- 2016
15. Etiology of nocturia response in men with diminished bladder capacity
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Jeffrey P. Weiss, Matthew Epstein, and Thomas F. Monaghan
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Male ,medicine.medical_specialty ,Urology ,Urinary Bladder ,030232 urology & nephrology ,Urination ,Bladder capacity ,Nocturnal ,urologic and male genital diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Nocturia ,Humans ,Desmopressin ,Aged ,Retrospective Studies ,Aged, 80 and over ,030219 obstetrics & reproductive medicine ,business.industry ,Middle Aged ,medicine.disease ,female genital diseases and pregnancy complications ,Overactive bladder ,Etiology ,Urology clinic ,Neurology (clinical) ,Metabolic syndrome ,medicine.symptom ,business ,medicine.drug - Abstract
AIMS To test the hypothesis that patients with nocturia owing to diminished global or nocturnal bladder capacity improve via increased bladder capacity. METHODS This is a retrospective analysis of voiding diaries completed at a VA urology clinic between 2008-2017. Inclusion required patients aged at least 18 years, male, undergoing treatment for nocturia, and having completed at least two 24-hour voiding diaries ≥1 month apart. Patients were divided into two cohorts: responders (any decline in nocturia) and non-responders (no change or any increase in nocturia). Patients were further sub-stratified as having low global bladder capacity (maximum voided volume [MVV]
- Published
- 2018
16. Would a new definition and classification of nocturia and nocturnal polyuria improve our management of patients? ICI-RS 2014
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Hashim Hashim, M. Sajjad Rahnama'I, Karel Everaert, An Sofie Goessaert, Jeffrey P. Weiss, Joshua Aizen, and J.L.H. Ruud Bosch
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education.field_of_study ,Nocturnal polyuria ,business.industry ,Urology ,Population ,Applied psychology ,030232 urology & nephrology ,Clinical neurology ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,medicine ,Nocturia ,Neurology (clinical) ,medicine.symptom ,Bladder diary ,business ,education - Abstract
The following is a report of the proceedings of the Nocturia Think Tank sessions of the annual International Consultation on Incontinence-Research Society, which took place September 22-24, 2014 in Bristol, UK. The report is organized into sections pertaining to the main topic of discussion focussing on the question as to whether a new definition and classification of nocturia and nocturnal polyuria would improve the outcome of management in our patients. First, discussions identified theoretical and practical shortcomings of current definitions. Secondly, the utility of several nocturnal polyuria definitions was tested in a real life population in relation to the symptom nocturia, in order to display weaknesses of these definitions. Thirdly, we explored in a clinical population the utility of bladder diary based parameters by asking the question: when nocturia improves, which of these parameters improve most? Based on the above explorations the Think Tank summarized elements of the current definitions that need reconsideration and suggests proposals for further research to reach more practical and more clinically meaningful definitions.
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- 2015
17. How can we develop a more clinically useful and robust algorithm for diagnosing and treating nocturia? ICI-RS 2017
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Roger R. Dmochowski, Noam D. Fine, Michel Wyndaele, Alan J. Wein, Karel Everaert, Wendy Bower, François Hervé, Jeffrey P. Weiss, and Jens Christian Djurhuus
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medicine.medical_specialty ,Nocturnal polyuria ,Urology ,030232 urology & nephrology ,Therapeutic algorithm ,urologic and male genital diseases ,Double blind ,03 medical and health sciences ,0302 clinical medicine ,diagnostics ,Medicine ,Nocturia ,Humans ,Intensive care medicine ,pathophysiology ,practice guidelines ,Medical treatment ,business.industry ,nocturnal polyuria ,medicine.disease ,female genital diseases and pregnancy complications ,Overactive bladder ,030220 oncology & carcinogenesis ,treatments ,Neurology (clinical) ,medicine.symptom ,business ,Sleep ,Societies ,Algorithms ,nocturia - Abstract
Aims: Nocturia, or waking up at night to void, is a highly prevalent and bothersome symptom. Currently, there is a lack of clear and consistent recommendations regarding evaluation and management of nocturia. The aim of this report is to discuss how to fill the gaps in our knowledge in order to develop a practical patient-oriented diagnostic and therapeutic algorithm for nocturia. Methods: This paper is a report of the presentations and subsequent discussion of a Think Tank session at the annual International Consultation on Incontinence Research Society (ICI-RS) in June 2017 in Bristol. Results and Conclusion: Further investigations are needed to better understand the pathophysiology of nocturia, to allow improvement in diagnosis, and to optimize treatment by increasing efficacy and reducing adverse events. Patient-oriented practical guidelines on nocturia are needed to help clinicians from different disciplines diagnose and treat nocturia.
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- 2017
18. Management of nocturia: The role of antidiuretic pharmacotherapy
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Jeffrey P. Weiss, Kristian Vinter Juul, and Alan J. Wein
- Subjects
medicine.medical_specialty ,business.industry ,Urology ,urologic and male genital diseases ,Placebo ,medicine.disease ,female genital diseases and pregnancy complications ,Pharmacotherapy ,Internal medicine ,Anesthesia ,Medicine ,Desmopressin Acetate ,Nocturia ,Neurology (clinical) ,Alpha blocker ,medicine.symptom ,business ,Desmopressin ,Hyponatremia ,Antidiuretic ,medicine.drug - Abstract
Strategies to manage nocturia include lifestyle modifications and treatment with alpha-blockers, antimuscarinic therapies, and antidiuretics. The concept of achieving success should not be limited to reduction of nighttime voids; it should ideally include proof of improvement of conditions generally associated with nocturia, such as falls, quality of life, and overall health. Few studies have looked specifically at parameters other than nocturnal voids, such as sleep latency, first undisturbed sleep period (FUSP), and total sleep time, including their clinical relevance to patient well-being. Lifestyle modifications, such as voiding before bedtime, limiting caffeine and alcohol, and adjusting medication timing, may be initially effective in mild cases of nocturia. Statistically significant reductions in voiding have been reported with antimuscarinic agents and alpha-blockers as initial therapy, but these reductions generally are not clinically relevant. The antidiuretic therapy desmopressin acetate, a selective vasopressin receptor 2 agonist, is effective in adults with nocturia associated with nocturnal polyuria; however, hyponatremia can occur. The newest formulation-desmopressin orally disintegrating sublingual tablet (ODST)--has greater bioavailability; thus, lower doses can be used, potentially reducing hyponatremia risk. A phase 3 study demonstrated statistically significant reductions in nocturnal voids for desmopressin ODST 50 and 100 µg versus placebo (-1.18 and -1.43 vs. -0.86; P = 0.02 and P < 0.0001, respectively) in patients with nocturia. Treatment was well-tolerated, and low-dose desmopressin ODST was associated with statistically significant increases in duration of FUSP. Development of a validated composite endpoint may help clinicians identify and compare strategies for treating nocturia.
- Published
- 2014
19. Nocturia treatment outcomes: Analysis of contributory frequency volume chart parameters
- Author
-
Jerry G. Blaivas, Alan J. Wein, Jeffrey P. Weiss, and Matthew Epstein
- Subjects
Gerontology ,Male ,medicine.medical_specialty ,Urology ,Treatment outcome ,030232 urology & nephrology ,Drinking ,Urination ,Bladder capacity ,03 medical and health sciences ,FEV1/FVC ratio ,0302 clinical medicine ,Internal medicine ,medicine ,Nocturia ,Humans ,Aged ,Retrospective Studies ,business.industry ,Significant difference ,Sleep architecture ,Frequency volume chart ,030220 oncology & carcinogenesis ,Cohort ,Neurology (clinical) ,medicine.symptom ,business ,Sleep - Abstract
Aims Our aim is to determine which changes in frequency volume chart (FVC) parameters are associated with nocturia improvement. Methods This is a real life retrospective analysis of FVC's of men who were treated for nocturia and completed at least two 24 h FVC's. Patients were divided into two groups—an improved cohort defined by a decrease of ≥1 nocturnal void from baseline and a non-improved cohort. Results A total of 414 FVC's were analyzed (207 baseline and 207 post treatment) among a cohort of 105 men. Baseline nocturia severity (ANV, 3.5 vs. 2.3, respectively) and nocturnal urine volume (NUV, 880 mL vs. 650 mL) was greater in the improved cohort compared to the non-improved cohort. The improved cohort had a decreased 24 h volume (−310 vs. +120 mL), and NUV (−290 vs. +170 mL) compared to the non-improved cohort. At the followup visit, the improved cohort experienced a statistically significant decline in ANV (−1.8 vs. +1.0). No significant difference was seen in baseline 24 h volume or bladder capacity (MVV), though patients in the improved cohort experienced a small decrease in MVV. First uninterrupted sleep period (FUSP) increased significantly in the improved cohort (+1.8 h), and dropped (−0.6 h) in the non-improved cohort. Conclusions Improvement in nocturia was associated with a decrease in both 24 h voided volume and NUV, but not MVV, suggesting that improved patients consumed less fluid. The increase in FUSP in the improved cohort demonstrates the potential for nocturia therapies to improve impaired sleep architecture.
- Published
- 2016
20. Reliability and validity of the overactive bladder symptom score in spanish (OABSS-S)
- Author
-
Jerry G. Blaivas, Jeffrey P. Weiss, Matthew P. Rutman, Aaron C. Weinberg, Gary H. Brandeis, John Bruyere, and Johnson F. Tsui
- Subjects
medicine.medical_specialty ,Psychometrics ,business.industry ,Urology ,Discriminant validity ,Urination disorder ,Subgroup analysis ,Cronbach's alpha ,Severity of illness ,Post-hoc analysis ,Physical therapy ,Medicine ,Neurology (clinical) ,business ,Chi-squared distribution - Abstract
Purpose To validate the Spanish translation of the Overactive Bladder Symptom Score (OABSS) questionnaire. Materials and Methods The OABSS was translated into Spanish (OABSS-S) and back translated. The OABSS-S was self-administered to subjects, following internal IRB and ISPOR Good Practices guidelines. Spanish speaking patients >18 years of age were recruited from primary care clinics. Content validity was achieved by having the first 25 subjects complete the questionnaire in privacy; afterwards they were interviewed and the clarity of each question was discussed with the patient. All subjects recruited, including the first 25, were divided into two groups by the presence of OAB as determined by a previously validated intake question. Subjects completed the OABSS-S in privacy on two occasions within 10 days. Patients were excluded if their symptoms changed between the first and second administration of the questionnaire. Internal consistency was determined with Cronbach's alpha. Test–retest was determined by Spearman's rho. Discriminant validity was assessed between each group using one-way ANOVA and the Tukey post hoc test. Results One hundred and seventeen of 128 enrolled subjects completed this study (mean age 55; SD 18). Of 117, 74 (63%) were women 29 with OAB and 45 without OAB. There were 43 men (37%), 18 with OAB and 25 without OAB. A high level of consistency was observed among the seven items answered at visit 1 and 2, with a Cronbach's raw alpha statistic of 0.92. No differences in OABSS-S with age or gender were noted. However, subgroup analysis showed patients in the OAB group were significantly older and post-test analysis showed they had higher scores both for each individual question as well as overall symptom severity scores. Spearman's rank order correlation coefficients showed that there was significant difference between the seven items of the OABSS-S; a strong association (Spearman's rho) was also observed between the total seven-item score at visits 1 and 2 for the total score of all subjects r = 0.84, with OAB: r = 0.81, and without OAB: r = 0.83. Comparison of average total scores obtained for all patients at visits 1 and 2 was not significant (10.47 ± 6.53 vs. 11.02 ± 0.66). Discriminant validity testing revealed that there were significant differences in the responses between all diagnostic groups at visits 1 and 2: with OAB versus without OAB; total versus with OAB; total versus without OAB. Conclusion The Spanish version of the OABSS is valid and reliable and will allow health care providers to easily and quickly assess a Spanish-speaking patient's symptoms. Neurourol. Urodynam. 31:664–668, 2012. © 2012 Wiley Periodicals, Inc.
- Published
- 2012
21. Nocturia think tank: Focus on nocturnal polyuria: ICI-RS 2011
- Author
-
Theodore M. Johnson, Roger R. Dmochowski, Hashim Hashim, Philip Van Kerrebroeck, Peggy Norton, Kristian Vinter Juul, Kari A.O. Tikkinen, Marcus J. Drake, Alan J. Wein, Jeffrey P. Weiss, Dudley Robinson, Jens Peter Nørgaard, Adonis Hijaz, and J.L.H. Ruud Bosch
- Subjects
Gerontology ,Nocturnal polyuria ,business.industry ,Urology ,030232 urology & nephrology ,Evidence-based medicine ,3. Good health ,Double blind ,03 medical and health sciences ,0302 clinical medicine ,Sex factors ,030220 oncology & carcinogenesis ,medicine ,Nocturia ,Neurology (clinical) ,medicine.symptom ,business - Abstract
The following is a report of the proceedings of the Nocturia Think Tank sessions of the annual International Consultation on Incontinence-Research Society, which took place June 13–15, 2011 in Bristol, UK. The report is organized into sections pertaining to the main topics of discussions having occurred at that meeting, centering on the relationship of nocturnal polyuria (NP) and nocturia but also synthesizing more current evidence advancing our knowledge of the diagnosis and management of nocturia. This article is not meant to be a comprehensive review on the subject of nocturia, a number of which are available in the recent literature. All authors were physically present during, or in a preliminary session just prior to, the meeting in Bristol. Neurourol. Urodynam. 31:330–339, 2012. © 2012 Wiley Periodicals, Inc.
- Published
- 2012
22. Defining urinary urgency: Patient descriptions of 'gotta go'
- Author
-
Gale Harding, Jeffrey P. Weiss, Zhanna Jumadilova, and Karin S. Coyne
- Subjects
Urinary urgency ,business.industry ,Urology ,media_common.quotation_subject ,Urinary incontinence ,medicine.disease ,Urination ,Developmental psychology ,Quality of life ,Overactive bladder ,Severity of illness ,medicine ,Content validity ,Neurology (clinical) ,medicine.symptom ,business ,media_common ,Clinical psychology ,Qualitative research - Abstract
Aims Urgency is a key symptom in the diagnosis of overactive bladder (OAB), yet its definition and measurement are subject to continuing debate whether urinary urgency is a pathologic sensation or an intensification of normal desire to pass urine. The objective of this research was to explore the concept of urgency among participants with OAB symptoms and to evaluate the content validity of the urinary sensation scale (USS). Methods Two qualitative studies were conducted among participants with OAB symptoms. For both studies, participants were interviewed on the USS to ascertain their ability to complete and interpret each response. Study 2 included open-ended questions to explore the concept of urgency with participants asked to describe “normal urge” and “urgency.” Results Thirty-one men and women (Study 1, n = 12; Study 2, n = 19) participated. Nearly all participants (n = 29) thought the word descriptions for the 1–5 scale were easy to comprehend and were able to differentiate among ratings by degree of severity. Study 2 noted little difference between continent (n = 9) and incontinent (n = 10) participant descriptions of “urge or desire to urinate” and “typical sensation.” The majority of the continent (n = 6) and incontinent (n = 7) participants stated they have both “regular” sensations to urinate and “urgent” sensations to urinate. Conclusions This qualitative research provides evidence that men and women with OAB symptoms can distinguish between “normal” urge (desire) to urinate and “urgency” suggesting that urinary urgency is a continuum, rather than an all-or-none phenomenon. The USS demonstrated content validity and was acceptable to patients. Neurourol. Urodynam. 31:455–459, 2012. © 2012 Wiley Periodicals, Inc.
- Published
- 2012
23. ICI-RS 2015-Is a better understanding of sleep the key in managing nocturia?
- Author
-
Marie-Astrid, Denys, Jerald, Cherian, Mohammad S, Rahnama'i, Kathleen A, O'Connell, Jonathan, Singer, Alan J, Wein, Karlien, Dhondt, Karel, Everaert, and Jeffrey P, Weiss
- Subjects
Adult ,Male ,Young Adult ,Adolescent ,Polyuria ,Humans ,Nocturia ,Middle Aged ,Sleep ,Aged ,Nocturnal Myoclonus Syndrome ,Retrospective Studies - Abstract
Nocturia, or waking up at night to void, is a highly prevalent and bothersome lower urinary tract symptom. However, the applied treatment modalities do not improve symptoms in about half of the patients. The aim of this report is to generate new ideas for future nocturia research, with special emphasis on the role of sleep physiology and sleep disorders.The following is a report of the presentations and subsequent discussion of the Nocturia Think Tank session at the annual meeting of the International Consultation on Incontinence Research Society (ICI-RS), which took place in September 2015 in Bristol. General information about the organization of the ICI-RS meeting can be found on the website "www.ici-rs.org." An overview of challenges within the existing evidence, future research ideas, and results of research with regard to nocturia and sleep were presented.In order to optimize the management of nocturia and nocturnal polyuria (NP), future research has to focus on the development of unambiguous terminology regarding nocturia and NP, the role of renal function profiles and simplified frequency volume charts as guidance of individualized therapy and the role of sleep disorders such as periodic limb movements during sleep and habitual voiding as a response to awakening. Neurourol. Urodynam. 37:2048-2052, 2018. © 2016 Wiley Periodicals, Inc.
- Published
- 2015
24. Nocturia: New Directions
- Author
-
Paul Abrams, Jeffrey P. Weiss, Roger Dmochowski, Alan J. Wein, Philip E. V. A. Van Kerrebroeck, Kari A O Tikkinen, Marypat Fitzgerald, Urologie, and RS: CAPHRI School for Public Health and Primary Care
- Subjects
Gerontology ,Biomedical Research ,Urology ,Treatment outcome ,MEDLINE ,future research ,Quality of life (healthcare) ,Cost of Illness ,Lower urinary tract symptoms ,Terminology as Topic ,medicine ,Cost of illness ,Prevalence ,Nocturia ,Animals ,Humans ,lower urinary tract symptoms ,business.industry ,Health Care Costs ,medicine.disease ,Treatment Outcome ,quality of life ,Neurology (clinical) ,medicine.symptom ,business ,nocturia - Abstract
The Nocturia Think Tank (TT) met during the 2010 meeting of the International Consultation on Incontinence-Research Society to discuss present knowledge and future directions in care and research of this prominent component of the spectrum of lower urinary tract symptoms. Questions raised included whether nocturia should be re-defined as a function of its bother, effects on quality of life, and economic impact upon society. At issue is the need to delineate the determinants of successful nocturia management. The multifactorial nature of nocturia requires that progress in its treatment will be dependent upon the cooperative investigation on the part of urologists, urogynecologists, geriatricians, epidemiologists, medical economists and pharma. Areas for future avenues of research were outlined at the conclusion of the meeting. Wiley-Liss, Inc.
- Published
- 2011
25. Reference values for the nocturnal bladder capacity index
- Author
-
Matthew Parsons, Jeffrey P. Weiss, Jerry G. Blaivas, Alfred C. Coats, and Claire Burton
- Subjects
Gynecology ,medicine.medical_specialty ,education.field_of_study ,business.industry ,Urology ,media_common.quotation_subject ,Population ,Bladder capacity ,Nocturnal ,medicine.disease ,Urination ,Asymptomatic ,Lower urinary tract symptoms ,medicine ,Nocturia ,Cutoff ,Neurology (clinical) ,medicine.symptom ,education ,business ,media_common - Abstract
Aims: The Nocturnal Bladder Capacity Index (NBCi) has been reported to be useful in distinguishing between nocturia caused by low bladder capacity and nocturnal polyuria. This paper aims to calculate reference values for NBCi from an asymptomatic population by comparing these with NBCi values from patients with lower urinary tract symptoms (LUTS) to obtain an indication of the sensitivity with which the NBCi detects low nocturnal bladder capacity. This paper also compares the sensitivity of rounded and unrounded calculations of NBCi. Methods: Computer processed 3-day bladder diaries from 253 asymptomatic volunteers and 184 female patients with LUTS were analyzed. NBCi values were calculated from each diary using rounded and unrounded formulae. 90th and 95th centile NBCi cutoff values were obtained from frequency distributions. Results: NBCi reference values from the asymptomatic group were 1.1 (unrounded) and 0.7 (rounded) for 90th centile, and 1.3 (unrounded) and 1.0 (rounded) for 95th centile. The use of the rounded formula gave identical NBCi values despite a large variation in Vn/Vmax ratios whereas unrounded NBCis varied continuously with Vn/Vmax ratios. The unrounded formula found significantly more elevated NBCis in the patient group. Conclusion: We suggest that an unrounded NBCi of 1.3 be considered a cutoff point above which reduced nocturnal bladder capacity should be investigated as a cause of nocturia. Rounding the NBCi lead to an underestimation of elevated values in a population of female patients with LUTS. Neurourol. Urodynam. 30:52–57, 2011. © 2010 Wiley-Liss, Inc.
- Published
- 2010
26. Would a new definition and classification of nocturia and nocturnal polyuria improve our management of patients? ICI-RS 2014
- Author
-
J L H Ruud, Bosch, Karel, Everaert, Jeffrey P, Weiss, Hashim, Hashim, M Sajjad, Rahnama'i, An-Sofie, Goessaert, and Joshua, Aizen
- Subjects
Aged, 80 and over ,Male ,Consensus ,Polyuria ,Congresses as Topic ,Middle Aged ,Prognosis ,Decision Support Techniques ,Predictive Value of Tests ,Terminology as Topic ,Critical Pathways ,Humans ,Female ,Nocturia ,Algorithms ,Aged - Abstract
The following is a report of the proceedings of the Nocturia Think Tank sessions of the annual International Consultation on Incontinence-Research Society, which took place September 22-24, 2014 in Bristol, UK. The report is organized into sections pertaining to the main topic of discussion focussing on the question as to whether a new definition and classification of nocturia and nocturnal polyuria would improve the outcome of management in our patients. First, discussions identified theoretical and practical shortcomings of current definitions. Secondly, the utility of several nocturnal polyuria definitions was tested in a real life population in relation to the symptom nocturia, in order to display weaknesses of these definitions. Thirdly, we explored in a clinical population the utility of bladder diary based parameters by asking the question: when nocturia improves, which of these parameters improve most? Based on the above explorations the Think Tank summarized elements of the current definitions that need reconsideration and suggests proposals for further research to reach more practical and more clinically meaningful definitions.
- Published
- 2015
27. Development and validation of a new treatment outcome score for men with LUTS
- Author
-
Christopher J. Di Blasio, Jennifer T. Anger, Jeffrey P. Weiss, Jason Gerboc, Jerry G. Blaivas, and Georgia Panagopoulos
- Subjects
Male ,Ordinal data ,medicine.medical_specialty ,Urinalysis ,Urology ,Prostatic Hyperplasia ,Cronbach's alpha ,Lower urinary tract symptoms ,Surveys and Questionnaires ,Post-hoc analysis ,Criterion validity ,Humans ,Medicine ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Middle Aged ,Urination Disorders ,medicine.disease ,Surgery ,Treatment Outcome ,Cohort ,Physical therapy ,International Prostate Symptom Score ,Neurology (clinical) ,business - Abstract
Aims To develop, validate, and test elements of a new outcome score for men with lower urinary tract symptoms (LUTS). Methods Elements of well-established questions from the International Prostate Symptom Score (IPSS) assessment were combined with both established noninvasive objective determinants of voiding function including maximum uroflow (Qmax), postvoid residual urine volume (PVR), total number voids, maximum voided volume (MVV) as well as a subjective patient assessment parameter, to create a new LUTS treatment outcome instrument which we have termed the “LUTS outcome score” (LOS). The LOS is comprised of eight items; each assigned a score of 0, 1, or 2. Thus, the score ranges from 0 (best) to 16 (worst). Patients were divided into surgical/non- surgical (pharmacologic or behavior modification) treatment groups. Content validity and cutoff values for cure/improve/fail were established by an expert panel. Criterion validity was established by comparison to the IPSS. Internal reliability analysis was performed to obtain information about the relationships between individual items in the scale. Individual LOS items were correlated with the subjective outcome score. We also calculated the correlations between the LOS, IPSS, subjective post-treatment response, and age. Internal consistency, based on the average inter-item correlation was calculated using Cronbach's alpha statistic. Associations between continuous variables were examined by calculating the Pearson correlation coefficient, and between ordinal variables, using Spearman's rho. Test–retest analysis was recorded to determine reproducibility of the patient subjective outcome score. Seventy-seven men who underwent treatment for LUTS for at least 6 months participated in the study. All completed a detailed pretreatment and post-treatment clinical evaluation consisting of history/physical, questionnaire, voiding diary, urinalysis, Q, PVR, and videourodynamic study. Subjective responses of cured/improved/failed status following treatment were assessed by independent investigators. Results A high level of internal consistency was observed among the LOS symptom questions, Cronbach's alpha = 0.81 for the total cohort. The LOS correlated directly and significantly with the patient's subjective post-treatment response (r = 0.75, P
- Published
- 2004
28. The standardisation of terminology in nocturia: Report from the standardisation sub-committee of the International Continence Society
- Author
-
Gary L. Robertson, Philip Van Kerrebroeck, Jeffrey P. Weiss, Theodore M. Johnson, Paul Abrams, Gunnar Lose, Jenny L Donovan, Poul Jennum, Simon Jackson, David C. Chaikin, Anders Mattiasson, and David Fonda
- Subjects
medicine.medical_specialty ,Nocturnal polyuria ,Polyuria ,business.industry ,Urology ,Urination Disorders ,Terminology ,Terminology as Topic ,Family medicine ,medicine ,Humans ,Nocturia ,Neurology (clinical) ,medicine.symptom ,business - Published
- 2002
29. Future research guidance for nocturia
- Author
-
Jeffrey P, Weiss, Alan J, Wein, and Philip, Van Kerrebroeck
- Subjects
Biomedical Research ,Quality of Life ,Humans ,Nocturia ,Algorithms ,Circadian Rhythm - Published
- 2013
30. Management of nocturia: the role of antidiuretic pharmacotherapy
- Author
-
Jeffrey P, Weiss, Kristian V, Juul, and Alan J, Wein
- Subjects
Treatment Outcome ,Drug Therapy ,Antidiuretic Agents ,Humans ,Nocturia ,Muscarinic Antagonists ,Life Style ,Adrenergic alpha-Antagonists - Abstract
Strategies to manage nocturia include lifestyle modifications and treatment with alpha-blockers, antimuscarinic therapies, and antidiuretics. The concept of achieving success should not be limited to reduction of nighttime voids; it should ideally include proof of improvement of conditions generally associated with nocturia, such as falls, quality of life, and overall health. Few studies have looked specifically at parameters other than nocturnal voids, such as sleep latency, first undisturbed sleep period (FUSP), and total sleep time, including their clinical relevance to patient well-being. Lifestyle modifications, such as voiding before bedtime, limiting caffeine and alcohol, and adjusting medication timing, may be initially effective in mild cases of nocturia. Statistically significant reductions in voiding have been reported with antimuscarinic agents and alpha-blockers as initial therapy, but these reductions generally are not clinically relevant. The antidiuretic therapy desmopressin acetate, a selective vasopressin receptor 2 agonist, is effective in adults with nocturia associated with nocturnal polyuria; however, hyponatremia can occur. The newest formulation-desmopressin orally disintegrating sublingual tablet (ODST)--has greater bioavailability; thus, lower doses can be used, potentially reducing hyponatremia risk. A phase 3 study demonstrated statistically significant reductions in nocturnal voids for desmopressin ODST 50 and 100 µg versus placebo (-1.18 and -1.43 vs. -0.86; P = 0.02 and P0.0001, respectively) in patients with nocturia. Treatment was well-tolerated, and low-dose desmopressin ODST was associated with statistically significant increases in duration of FUSP. Development of a validated composite endpoint may help clinicians identify and compare strategies for treating nocturia.
- Published
- 2013
31. Two types of urgency
- Author
-
Jeffrey P. Weiss, Jerry G. Blaivas, Chandra Somaroo, and Georgia Panagopoulos
- Subjects
medicine.medical_specialty ,Urinary urgency ,business.industry ,Urology ,media_common.quotation_subject ,Different sensation ,medicine.disease ,Urination ,Developmental psychology ,Cohen's kappa ,Overactive bladder ,Sensation ,Etiology ,Physical therapy ,Medicine ,In patient ,Neurology (clinical) ,medicine.symptom ,business ,media_common - Abstract
Aims To determine whether urinary urgency, as defined by the International Continence Society, is an intensification of the normal sensation that occurs when micturition must be delayed once the urge to void is felt (Type 1 urgency) or a discrete, pathologic symptom different from the normal urge (Type 2 urgency). Methods Forty-eight consecutive patients who complained of urinary urgency completed two different questionnaires designed to answer the question posed above. The patients were divided into two groups of 24. For the test–retest, group 1 completed questionnaire 1 twice within 3–10 days and group 2 did the same with questionnaire 2. On the second administration of the questionnaire, each subject crossed over and answered the other questionnaire. For the test–retest, since the data set is dichotomous (yes/no), the degree of agreement between the two sets of data was assessed by calculating the kappa coefficient. Results There were 37 women and 11 men ranging in age from 54 to 87 years. There was no difference in age and sex between the two groups (P = 0.19). There was excellent agreement in the test–retest responses for both questionnaires (kappa = 1.0, P
- Published
- 2009
32. Evaluation of the etiology of nocturia in men: The nocturia and nocturnal bladder capacity indices
- Author
-
Jeffrey P. Weiss, Jerry G. Blaivas, Doron S. Stember, and David C. Chaikin
- Subjects
medicine.medical_specialty ,business.industry ,Urology ,media_common.quotation_subject ,Bladder capacity ,Urine ,Nocturnal ,urologic and male genital diseases ,medicine.disease ,Urination ,female genital diseases and pregnancy complications ,Lower urinary tract symptoms ,American Urological Association Symptom Score ,Etiology ,medicine ,Nocturia ,Neurology (clinical) ,medicine.symptom ,business ,media_common - Abstract
To determine and quantify the cause of nocturia in men, we describe and evaluate the relative contribution of two complementary indices of nocturia: the nocturia index (Ni), a measure of nocturnal urine overproduction, and the nocturnal bladder capacity index (NBCi), reflective of nocturnal bladder capacity. The records of 100 consecutive men with lower urinary tract symptoms (LUTS), having undergone video-urodynamic studies (VUDS), were prospectively studied. Evaluation included American Urological Association symptom score (AUASS), micturition diary (day, night, and 24-hr voided volume), and VUDS. Voiding diary analysis was carried out as previously described by us, determining the Ni, NBCi, and nocturnal polyuria index (NPi) (nocturnal urine volume/24-hr urine volume). In the case of AUASS question #7 (degree of nocturia), the odds of having a severe AUA question #7 response was found to be 4.09 times higher for patients with NBCi > 2.0 compared with patients whose NBCi was 2 as highly significant in defining diminished NBC as a factor in the etiology of nocturia. In addition, we propose Ni of 1.5 as a threshold greater than which nocturia may be attributed to nocturnal urine overproduction in excess of maximum bladder capacity. Together, these indices describe in quantitative fashion the relative contributions of nocturnal urine overproduction and diminished NBC in identifying the etiology of nocturia in male patients. Neurourol. Urodynam. 18:559-565, 1999.
- Published
- 1999
33. Nocturia in adults: Etiology and classification
- Author
-
Jeffrey P. Weiss, Doron S. Stember, Jerry G. Blaivas, and Maria M. Brooks
- Subjects
medicine.medical_specialty ,business.industry ,Urology ,media_common.quotation_subject ,Functional bladder capacity ,Bladder capacity ,Retrospective cohort study ,Urine ,urologic and male genital diseases ,Urination ,female genital diseases and pregnancy complications ,Polyuria ,Etiology ,Medicine ,Nocturia ,Neurology (clinical) ,medicine.symptom ,business ,media_common - Abstract
Nocturia is one of the most bothersome of all urologic symptoms, yet even a rudimentary classification does not exist. We herein propose a classification system of nocturia based on a retrospective study. The records of 200 consecutive patients with nocturia were reviewed. Evaluation included history, micturition diary (including day, night, and 24-hr voided volume), postvoid residual urine (PVR), and videourodynamic study (VUDS). Functional bladder capacity (FBC) was determined to be the largest voided volume in a 24-hr period. The etiology of nocturia was thus classified into one of three groups: nocturnal polyuria ([NP] in which voided urine volume during the hours of sleep exceeds 35% of the 24-hr output), nocturnal detrusor overactivity ([NDO] defined as nocturia attributable to diminished bladder capacity during the hours of sleep), and mixed (NP+NDO); polyuria (24-hr urine output >2,500 cc) was classified separately. There were 129 women and 65 men ranging in age from 17 to 94 years (x=59). Overall 13 (7%) had NP, 111 (57%) NDO, and 70 (36%) had a mixed etiology of their nocturia (both NP and NDO). Forty-five (23%) also had polyuria. These data confirm that the etiology of nocturia is multifactorial and in many instances unrelated to the underlying urologic condition. Nocturnal overproduction of urine is a significant component of nocturia in 43% of patients, most of whom will also have NDO. We believe that treatment should be directed at both conditions.
- Published
- 1998
34. Desmopressin orally disintegrating tablet effectively reduces nocturia: results of a randomized, double-blind, placebo-controlled trial
- Author
-
Norman R. Zinner, Jens Peter Nørgaard, Bjarke Mirner Klein, and Jeffrey P. Weiss
- Subjects
Orally disintegrating tablet ,Male ,medicine.medical_specialty ,Urology ,Population ,Placebo-controlled study ,Administration, Oral ,urologic and male genital diseases ,Placebo ,law.invention ,Randomized controlled trial ,Double-Blind Method ,law ,Surveys and Questionnaires ,medicine ,Nocturia ,Humans ,Deamino Arginine Vasopressin ,Desmopressin ,education ,Aged ,Aged, 80 and over ,education.field_of_study ,business.industry ,Antidiuretic Agents ,Middle Aged ,Treatment Outcome ,Tolerability ,Anesthesia ,Female ,Neurology (clinical) ,medicine.symptom ,business ,medicine.drug - Abstract
The primary objective was to investigate the efficacy of desmopressin orally disintegrating tablet versus placebo in patients with nocturia. Pharmacodynamics, safety and patient-reported quality of life (QoL) outcomes were also evaluated. One of several benefits of the new formulation is increased bioavailability. Exploring lower doses allows for a better evaluation of therapeutic effect versus tolerability.This was a 4-week, randomized, double-blind study comparing 10, 25, 50, or 100 µg desmopressin versus placebo in adults with defined nocturia.The intent to treat population comprised 757 patients experiencing ∼3 voids/night and a high prevalence of nocturnal polyuria (∼90%). Increasing doses of desmopressin were associated with decreasing numbers of nocturnal voids and voided volume, greater proportions of subjects with33% reduction in nocturnal voids, and increased duration of first sleep period. The lowest dose reaching statistical significance (P 0.05 vs. placebo) varied by endpoint. Improvements were clinically meaningful, meaning that patients actually had fewer nightly voids. Post hoc analyses by gender suggested a lower minimum effective dose for women. Desmopressin was generally well tolerated. Reductions in serum sodium to125 mmol/L in six women (taking25 µg desmopressin) and two men (aged 67 and 82) taking 100 µg, support lower and gender-specific dosing to reduce the small but clinically significant risk of hyponatraemia. Each void reduced/hour of sleep gained was associated with significant improvements in QoL.Desmopressin orally disintegrating tablet is an effective and well-tolerated treatment for patients with nocturia. Further exploration of the lower dose range is warranted.
- Published
- 2011
35. Nocturia Think Tank: focus on nocturnal polyuria: ICI-RS 2011
- Author
-
Jeffrey P, Weiss, J L H Ruud, Bosch, Marcus, Drake, Roger R, Dmochowski, Hashim, Hashim, Adonis, Hijaz, Theodore M, Johnson, Kristian Vinter, Juul, Jens Peter, Nørgaard, Peggy, Norton, Dudley, Robinson, Kari A O, Tikkinen, Philip E V, Van Kerrebroeck, and Alan J, Wein
- Subjects
Male ,Evidence-Based Medicine ,Polyuria ,Urinary Bladder ,Age Factors ,Diagnostic Techniques, Urological ,Prognosis ,Circadian Rhythm ,Urodynamics ,Sex Factors ,Predictive Value of Tests ,Risk Factors ,Humans ,Female ,Nocturia - Abstract
The following is a report of the proceedings of the Nocturia Think Tank sessions of the annual International Consultation on Incontinence-Research Society, which took place June 13-15, 2011 in Bristol, UK. The report is organized into sections pertaining to the main topics of discussions having occurred at that meeting, centering on the relationship of nocturnal polyuria (NP) and nocturia but also synthesizing more current evidence advancing our knowledge of the diagnosis and management of nocturia. This article is not meant to be a comprehensive review on the subject of nocturia, a number of which are available in the recent literature. All authors were physically present during, or in a preliminary session just prior to, the meeting in Bristol.
- Published
- 2011
36. Reliability and validity of the Overactive Bladder Symptom Score in Spanish (OABSS-S)
- Author
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Aaron C, Weinberg, Gary H, Brandeis, John, Bruyere, Johnson F, Tsui, Jeffrey P, Weiss, Matthew P, Rutman, and Jerry G, Blaivas
- Subjects
Adult ,Male ,Analysis of Variance ,Chi-Square Distribution ,Psychometrics ,Urinary Bladder, Overactive ,Urinary Bladder ,Discriminant Analysis ,Reproducibility of Results ,Middle Aged ,Translating ,Severity of Illness Index ,Predictive Value of Tests ,Surveys and Questionnaires ,Humans ,Female ,Comprehension ,Aged ,Boston - Abstract
To validate the Spanish translation of the Overactive Bladder Symptom Score (OABSS) questionnaire.The OABSS was translated into Spanish (OABSS-S) and back translated. The OABSS-S was self-administered to subjects, following internal IRB and ISPOR Good Practices guidelines. Spanish speaking patients18 years of age were recruited from primary care clinics. Content validity was achieved by having the first 25 subjects complete the questionnaire in privacy; afterwards they were interviewed and the clarity of each question was discussed with the patient. All subjects recruited, including the first 25, were divided into two groups by the presence of OAB as determined by a previously validated intake question. Subjects completed the OABSS-S in privacy on two occasions within 10 days. Patients were excluded if their symptoms changed between the first and second administration of the questionnaire. Internal consistency was determined with Cronbach's alpha. Test-retest was determined by Spearman's rho. Discriminant validity was assessed between each group using one-way ANOVA and the Tukey post hoc test.One hundred and seventeen of 128 enrolled subjects completed this study (mean age 55; SD 18). Of 117, 74 (63%) were women 29 with OAB and 45 without OAB. There were 43 men (37%), 18 with OAB and 25 without OAB. A high level of consistency was observed among the seven items answered at visit 1 and 2, with a Cronbach's raw alpha statistic of 0.92. No differences in OABSS-S with age or gender were noted. However, subgroup analysis showed patients in the OAB group were significantly older and post-test analysis showed they had higher scores both for each individual question as well as overall symptom severity scores. Spearman's rank order correlation coefficients showed that there was significant difference between the seven items of the OABSS-S; a strong association (Spearman's rho) was also observed between the total seven-item score at visits 1 and 2 for the total score of all subjects r = 0.84, with OAB: r = 0.81, and without OAB: r = 0.83. Comparison of average total scores obtained for all patients at visits 1 and 2 was not significant (10.47 ± 6.53 vs. 11.02 ± 0.66). Discriminant validity testing revealed that there were significant differences in the responses between all diagnostic groups at visits 1 and 2: with OAB versus without OAB; total versus with OAB; total versus without OAB.The Spanish version of the OABSS is valid and reliable and will allow health care providers to easily and quickly assess a Spanish-speaking patient's symptoms.
- Published
- 2011
37. Defining urinary urgency: patient descriptions of 'gotta go'
- Author
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Karin S, Coyne, Gale, Harding, Zhanna, Jumadilova, and Jeffrey P, Weiss
- Subjects
Adult ,Aged, 80 and over ,Male ,Urinary Bladder, Overactive ,Reproducibility of Results ,Urination ,Urinary Incontinence, Urge ,Middle Aged ,Severity of Illness Index ,Surveys and Questionnaires ,Quality of Life ,Humans ,Female ,Aged - Abstract
Urgency is a key symptom in the diagnosis of overactive bladder (OAB), yet its definition and measurement are subject to continuing debate whether urinary urgency is a pathologic sensation or an intensification of normal desire to pass urine. The objective of this research was to explore the concept of urgency among participants with OAB symptoms and to evaluate the content validity of the urinary sensation scale (USS).Two qualitative studies were conducted among participants with OAB symptoms. For both studies, participants were interviewed on the USS to ascertain their ability to complete and interpret each response. Study 2 included open-ended questions to explore the concept of urgency with participants asked to describe "normal urge" and "urgency."Thirty-one men and women (Study 1, n = 12; Study 2, n = 19) participated. Nearly all participants (n = 29) thought the word descriptions for the 1-5 scale were easy to comprehend and were able to differentiate among ratings by degree of severity. Study 2 noted little difference between continent (n = 9) and incontinent (n = 10) participant descriptions of "urge or desire to urinate" and "typical sensation." The majority of the continent (n = 6) and incontinent (n = 7) participants stated they have both "regular" sensations to urinate and "urgent" sensations to urinate.This qualitative research provides evidence that men and women with OAB symptoms can distinguish between "normal" urge (desire) to urinate and "urgency" suggesting that urinary urgency is a continuum, rather than an all-or-none phenomenon. The USS demonstrated content validity and was acceptable to patients.
- Published
- 2011
38. Nocturia research: current status and future perspectives
- Author
-
Roger R. Dmochowski, Philip Van Kerrebroeck, Mary P. FitzGerald, Dudley Robinson, Hashim Hashim, Jeffrey P. Weiss, Jens Peter Nørgaard, Urologie, RS: CAPHRI School for Public Health and Primary Care, and RS: MHeNs School for Mental Health and Neuroscience
- Subjects
medicine.medical_specialty ,Biomedical Research ,Combination therapy ,Urology ,MEDLINE ,urologic and male genital diseases ,Medical illness ,medicine ,Nocturia ,Humans ,Limited evidence ,Intensive care medicine ,Sleep period ,Gynecology ,High rate ,research ,business.industry ,LUTS ,medicine.disease ,Prognosis ,female genital diseases and pregnancy complications ,Treatment Outcome ,Overactive bladder ,Chronic Disease ,overactive bladder ,Neurology (clinical) ,medicine.symptom ,business - Abstract
This review summarizes the status of nocturia research, highlighting the condition's distinct nature, as well as areas where further studies are needed. Unlike other LUTS, nocturia has a specific and detrimental effect on the sleep period, and when >= 2 voids per night are experienced it is associated with various sequelae including reduced QoL and productivity, and increased morbidity and perhaps mortality. Many sources suggest that nocturia is associated with chronic medical illness, but little evidence demonstrates that successful treatment of these conditions results in normalization of nocturia, or that improvement in nocturia improves QoL and overall health. To date, management algorithms for LUTS have been based upon reasonable supposition and limited evidence, rather than controlled trials. Whilst a working clinical model is useful until conclusive research is available, a healthy scepticism should be maintained. It is likely that more than one contributory factor is responsible for nocturia, and management ought to better reflect this multifactorial pathophysiology. Indeed, traditional perspectives assuming nocturia to be part of the OAB or BPE symptom complex may have helped to propagate the misconception that therapy for these conditions is sufficient to improve nocturia. In reality, improvements in nocturia with anticholinergics, alpha-blockers and/or 5-alpha reductase inhibitors have been consistently disappointing. Antidiuretic therapy may represent a more tailored approach to management for many nocturia patients, given the high rates of nocturnal polyuria reported. Combination therapy may be required. Further high quality research on pathophysiology, management and patient-reported outcomes with treatment is needed to augment existing limited data. Neurourol. Urodynam. 29:623-628, 2010.
- Published
- 2010
39. Reference values for the Nocturnal Bladder Capacity Index
- Author
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Claire, Burton, Jeffrey P, Weiss, Matthew, Parsons, Jerry G, Blaivas, and Alfred C, Coats
- Subjects
Adult ,Aged, 80 and over ,Male ,Adolescent ,Polyuria ,Urinary Bladder ,Urination ,Middle Aged ,Diagnosis, Differential ,Young Adult ,Reference Values ,Humans ,Female ,Nocturia ,Aged - Abstract
The Nocturnal Bladder Capacity Index (NBCi) has been reported to be useful in distinguishing between nocturia caused by low bladder capacity and nocturnal polyuria. This paper aims to calculate reference values for NBCi from an asymptomatic population by comparing these with NBCi values from patients with lower urinary tract symptoms (LUTS) to obtain an indication of the sensitivity with which the NBCi detects low nocturnal bladder capacity. This paper also compares the sensitivity of rounded and unrounded calculations of NBCi.Computer processed 3-day bladder diaries from 253 asymptomatic volunteers and 184 female patients with LUTS were analyzed. NBCi values were calculated from each diary using rounded and unrounded formulae. 90th and 95th centile NBCi cutoff values were obtained from frequency distributions.NBCi reference values from the asymptomatic group were 1.1 (unrounded) and 0.7 (rounded) for 90th centile, and 1.3 (unrounded) and 1.0 (rounded) for 95th centile. The use of the rounded formula gave identical NBCi values despite a large variation in V(n) /V(max) ratios whereas unrounded NBCis varied continuously with V(n) /V(max) ratios. The unrounded formula found significantly more elevated NBCis in the patient group.We suggest that an unrounded NBCi of 1.3 be considered a cutoff point above which reduced nocturnal bladder capacity should be investigated as a cause of nocturia. Rounding the NBCi lead to an underestimation of elevated values in a population of female patients with LUTS.
- Published
- 2009
40. Two types of urgency
- Author
-
Jerry G, Blaivas, Georgia, Panagopoulos, Jeffrey P, Weiss, and Chandra, Somaroo
- Subjects
Aged, 80 and over ,Male ,Cross-Over Studies ,Urinary Bladder, Overactive ,Surveys and Questionnaires ,Sensation ,Humans ,Reproducibility of Results ,Urination ,Female ,Middle Aged ,Urination Disorders ,Aged - Abstract
To determine whether urinary urgency, as defined by the International Continence Society, is an intensification of the normal sensation that occurs when micturition must be delayed once the urge to void is felt (Type 1 urgency) or a discrete, pathologic symptom different from the normal urge (Type 2 urgency).Forty-eight consecutive patients who complained of urinary urgency completed two different questionnaires designed to answer the question posed above. The patients were divided into two groups of 24. For the test-retest, group 1 completed questionnaire 1 twice within 3-10 days and group 2 did the same with questionnaire 2. On the second administration of the questionnaire, each subject crossed over and answered the other questionnaire. For the test-retest, since the data set is dichotomous (yes/no), the degree of agreement between the two sets of data was assessed by calculating the kappa coefficient.There were 37 women and 11 men ranging in age from 54 to 87 years. There was no difference in age and sex between the two groups (P = 0.19). There was excellent agreement in the test-retest responses for both questionnaires (kappa = 1.0, P0.001). For questionnaire 1, the urge sensation was an intensification of the normal sensation in 33 (68.8%) and it was a different sensation in 15 (31.3%). Similarly, for questionnaire 2, it was an intensification of the normal urge in 34 (70.8%) and different in 14 (29.2%). The differences in patient responses between the two groups were not significant. In the crossover section, only 1 of 48 subjects changed their response, resulting in a very high degree of agreement (kappa = .95, p.001). Combining the two groups, urgency was perceived as an intensification of the normal urge to void in 33/48 patients (69%), a different sensation in 14/48 (29%) and 1/48 (2%) was not sure.Urgency is comprised of at least two different sensations. One is an intensification of the normal urge to void and the other is a different sensation. The implications of this distinction are important insofar as they may have different etiologies and respond differently to treatment.
- Published
- 2009
41. Introduction and meeting recap
- Author
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Jeffrey P. Weiss, Philip Van Kerrebroeck, and Alan J. Wein
- Subjects
World Wide Web ,business.industry ,Urology ,Medicine ,Neurology (clinical) ,business - Published
- 2014
42. Future research guidance for nocturia
- Author
-
Philip Van Kerrebroeck, Alan J. Wein, and Jeffrey P. Weiss
- Subjects
medicine.medical_specialty ,business.industry ,Urology ,medicine ,Nocturia ,Medical physics ,Neurology (clinical) ,medicine.symptom ,business - Published
- 2013
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