1. Low-level gestational exposure to mercury and maternal fish consumption: Associations with neurobehavior in early infancy
- Author
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Kimberly Yolton, Heidi Sucharew, Kim N. Dietrich, Yingying Xu, and Jane C. Khoury
- Subjects
Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Cord ,Offspring ,Developmental Disabilities ,Physiology ,chemistry.chemical_element ,Food Contamination ,Neuropsychological Tests ,010501 environmental sciences ,Toxicology ,01 natural sciences ,Article ,Cohort Studies ,Young Adult ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,0302 clinical medicine ,Developmental Neuroscience ,Pregnancy ,medicine ,Animals ,Humans ,030212 general & internal medicine ,Methylmercury ,0105 earth and related environmental sciences ,Psychiatric Status Rating Scales ,Analysis of Variance ,Dose-Response Relationship, Drug ,business.industry ,Fishes ,Infant ,Methylmercury Compounds ,medicine.disease ,Mercury (element) ,chemistry ,Prenatal Exposure Delayed Effects ,Cord blood ,Multivariate Analysis ,Cohort ,Gestation ,Female ,business - Abstract
Background Studies examining the effects of low-level gestational methylmercury exposure from fish consumption on infant neurobehavioral outcomes in the offspring are limited and inconclusive. Our objective was to examine the effects of low-level gestational exposure to methylmercury on neurobehavioral outcomes in early infancy. Methods We assessed neurobehavior of 344 infants at 5-weeks using the NICU Network Neurobehavioral Scale (NNNS). Gestational mercury exposure was measured as whole blood total mercury (WBTHg) in maternal and cord blood. We collected fish consumption information and estimated polyunsaturated fatty acid (PUFA) intake. We examined the association between gestational mercury exposure and NNNS scales using regression, adjusting for covariates. Results Geometric mean of maternal and cord WBTHg were 0.64 and 0.72 μg/L, respectively. Most mothers (84%) reported eating fish during pregnancy. Infants with higher prenatal mercury exposure showed increased asymmetric reflexes among girls (p = 0.04 for maternal WBTHg and p = 0.03 for cord WBTHg), less need for special handling during the assessment (p = 0.03 for cord WBTHg) and a trend of better attention (p = 0.054 for both maternal WBTHg and cord WBTHg). Similarly, infants born to mothers with higher fish consumption or estimated PUFA intake also had increased asymmetric reflexes and less need for special handling. In models simultaneously adjusted for WBTHg and fish consumption (or PUFA intake), the previously observed WBTHg effects were attenuated; and higher fish consumption (or PUFA intake) was significantly associated with less need for special handling. Conclusions In a cohort with low level mercury exposure and reporting low fish consumption, we found minimal evidence of mercury associated detrimental effects on neurobehavioral outcomes during early infancy. Higher prenatal mercury exposure was associated with more frequent asymmetric reflexes in girls. In contrast, infants with higher prenatal mercury exposure and those whose mothers consumed more fish had better attention and needed less special handling, which likely reflect the beneficial nutritional effects of fish consumption.
- Published
- 2016