1. Optogenetic modulation in stroke recovery
- Author
-
Allen L Ho, Eric S Sussman, Sabrina L. Levy, Arjun V Pendharkar, Michelle Y. Cheng, and Gary K. Steinberg
- Subjects
0301 basic medicine ,medicine.medical_treatment ,General Medicine ,Recovery of Function ,Biology ,Optogenetics ,medicine.disease ,EGF - Epidermal growth factor ,Neuromodulation (medicine) ,Stroke ,Translational Research, Biomedical ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine ,Animals ,Humans ,Surgery ,Neurology (clinical) ,Stroke recovery ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Stroke is one of the leading contributors to morbidity, mortality, and health care costs in the United States. Although several preclinical strategies have shown promise in the laboratory, few have succeeded in the clinical setting. Optogenetics represents a promising molecular tool, which enables highly specific circuit-level neuromodulation. Here, the conceptual background and preclinical body of evidence for optogenetics are reviewed, and translational considerations in stroke recovery are discussed.
- Published
- 2016