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Your search keyword '"Manjila, Sunil"' showing total 27 results
Start Over Author "Manjila, Sunil" Journal neurosurgical focus
27 results on '"Manjila, Sunil"'

1. Endoscopic precaruncular medial transorbital and endonasal multiport approaches to the contralateral skull base: a clinicoanatomical study

Author

Bhuskute, Govind S., primary, Gosal, Jaskaran Singh, additional, Alsavaf, Mohammad Bilal, additional, Manjila, Sunil, additional, Wu, Kyle C., additional, Alwabili, Mohammed, additional, Abouammo, Moataz D., additional, Manogaran, Ravi Sankar, additional, Lubbe, Darlene E., additional, Carrau, Ricardo L., additional, and Prevedello, Daniel M., additional

Published
2024
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2. Editorial. Long-term solutions in neurosurgery using extended reality technologies

Author

Vaysberg Anatoliy, Manjila Sunil, Kainth Tejasvi, Jain Shubham, Singh Gagandeep, Spektor Vadim, Manjila Nihal, and Prasanna Prateek

Subjects
medicine.medical_specialty, Surgery, Computer-Assisted, Computer science, Neurosurgery, medicine, Humans, Surgery, Operations management, Neurology (clinical), General Medicine, Neurosurgical Procedures, Term (time)
Published
2021

26. Human prion diseases: surgical lessons learned from iatrogenic prion transmission

Author

Fahd R. Khan, David J. Bonda, Gianfranco Puoti, Sunil Manjila, Lawrence B. Schonberger, Prachi Mehndiratta, Benjamin R. Miller, Kaine Onwuzulike, Ignazio Cali, Mark L. Cohen, Bonda, David J., Manjila, Sunil, Mehndiratta, Prachi, Khan, Fahd, Miller, Benjamin R., Onwuzulike, Kaine, Puoti, Gianfranco, Cohen, Mark L., Schonberger, Lawrence B., and Cali, Ignazio

Subjects
0301 basic medicine, medicine.medical_specialty, animal diseases, Bovine spongiform encephalopathy, Iatrogenic Disease, Neurosurgery, Endocannibalism, Disease, Neurosurgical Procedure, History, 21st Century, Creutzfeldt-Jakob Syndrome, Neurosurgical Procedures, Article, World health, Animal Diseases, Prion Diseases, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Humans, Intensive care medicine, Transmissible spongiform encephalopathy, Cross Infection, Animal, business.industry, General Medicine, History, 20th Century, medicine.disease, Virology, Prion Disease, nervous system diseases, 030104 developmental biology, Scrapie prion protein, Iatrogenic, Who guidelines, Instrument decontamination, Kuru, Cattle, Surgery, Neurology (clinical), business, Animal Disease, 030217 neurology & neurosurgery, Human
Abstract

The human prion diseases, or transmissible spongiform encephalopathies, have captivated our imaginations since their discovery in the Fore linguistic group in Papua New Guinea in the 1950s. The mysterious and poorly understood “infectious protein” has become somewhat of a household name in many regions across the globe. From bovine spongiform encephalopathy (BSE), commonly identified as mad cow disease, to endocannibalism, media outlets have capitalized on these devastatingly fatal neurological conditions. Interestingly, since their discovery, there have been more than 492 incidents of iatrogenic transmission of prion diseases, largely resulting from prion-contaminated growth hormone and dura mater grafts. Although fewer than 9 cases of probable iatrogenic neurosurgical cases of Creutzfeldt-Jakob disease (CJD) have been reported worldwide, the likelihood of some missed cases and the potential for prion transmission by neurosurgery create considerable concern. Laboratory studies indicate that standard decontamination and sterilization procedures may be insufficient to completely remove infectivity from prion-contaminated instruments. In this unfortunate event, the instruments may transmit the prion disease to others. Much caution therefore should be taken in the absence of strong evidence against the presence of a prion disease in a neurosurgical patient. While the Centers for Disease Control and Prevention (CDC) and World Health Organization (WHO) have devised risk assessment and decontamination protocols for the prevention of iatrogenic transmission of the prion diseases, incidents of possible exposure to prions have unfortunately occurred in the United States. In this article, the authors outline the historical discoveries that led from kuru to the identification and isolation of the pathological prion proteins in addition to providing a brief description of human prion diseases and iatrogenic forms of CJD, a brief history of prion disease nosocomial transmission, and a summary of the CDC and WHO guidelines for prevention of prion disease transmission and decontamination of prion-contaminated neurosurgical instruments.

Published
2016

27. The role of cancer stem cells in glioblastoma.

Author

Sundar SJ, Hsieh JK, Manjila S, Lathia JD, and Sloan A

Subjects
Humans, Neoplasm Recurrence, Local, Stem Cell Niche physiology, Brain Neoplasms pathology, Glioblastoma pathology, Neoplastic Stem Cells physiology
Abstract

Recurrence in glioblastoma is nearly universal, and its prognosis remains dismal despite significant advances in treatment over the past decade. Glioblastoma demonstrates considerable intratumoral phenotypic and molecular heterogeneity and contains a population of cancer stem cells that contributes to tumor propagation, maintenance, and treatment resistance. Cancer stem cells are functionally defined by their ability to self-renew and to differentiate, and they constitute the diverse hierarchy of cells composing a tumor. When xenografted into an appropriate host, they are capable of tumorigenesis. Given the critical role of cancer stem cells in the pathogenesis of glioblastoma, research into their molecular and phenotypic characteristics is a therapeutic priority. In this review, the authors discuss the evolution of the cancer stem cell model of tumorigenesis and describe the specific role of cancer stem cells in the pathogenesis of glioblastoma and their molecular and microenvironmental characteristics. They also discuss recent clinical investigations into targeted therapies against cancer stem cells in the treatment of glioblastoma.

Published
2014
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