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1. Comparison of Repeat Versus Initial Stereotactic Radiosurgery for Intracranial Arteriovenous Malformations: A Retrospective Multicenter Matched Cohort Study.

Author

Orrego Gonzalez, Eduardo, Mantziaris, Georgios, Shaaban, Ahmed, Starke, Robert M., Ding, Dale, Lee, John Y. K., Mathieu, David, Kondziolka, Douglas, Feliciano, Caleb, Grills, Inga S., Barnett, Gene H., Lunsford, L. Dade, Liščák, Roman, Cheng-chia Lee, Álvarez, Roberto Martinez, Peker, Selcuk, Samanci, Yavuz, Cockroft, Kevin M., Tripathi, Manjul, and Palmer, Joshua D.

Published
2024
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2. Postmortem Autopsy-Confirmation of Antemortem [F-18]FDDNP-PET Scans in a Football Player With Chronic Traumatic Encephalopathy.

Author

Omalu, Bennet, Small, Gary W, Bailes, Julian, Ercoli, Linda M, Merrill, David A, Wong, Koon-Pong, Huang, Sung-Cheng, Satyamurthy, Nagichettiar, Hammers, Jennifer L, Lee, John, Fitzsimmons, Robert P, and Barrio, Jorge R

Subjects
Biological Psychology, Psychology, Neurodegenerative, Traumatic Brain Injury (TBI), Acquired Cognitive Impairment, Biomedical Imaging, Dementia, Clinical Research, Behavioral and Social Science, Basic Behavioral and Social Science, Brain Disorders, Neurosciences, Neurological, Autopsy, Brain, Brain Injury, Chronic, Chronic Traumatic Encephalopathy, Football, Humans, Male, Middle Aged, Positron-Emission Tomography, Antemortem, CTE, [F-18] FDDNP-PET, Football player, [F-18]FDDNP-PET, Clinical Sciences, Neurology & Neurosurgery, Clinical sciences, Biological psychology
Abstract

Currently, only presumptive diagnosis of chronic traumatic encephalopathy (CTE) can be made in living patients. We present a modality that may be instrumental to the definitive diagnosis of CTE in living patients based on brain autopsy confirmation of [F-18]FDDNP-PET findings in an American football player with CTE. [F-18]FDDNP-PET imaging was performed 52 mo before the subject's death. Relative distribution volume parametric images and binding values were determined for cortical and subcortical regions of interest. Upon death, the brain was examined to identify the topographic distribution of neurodegenerative changes. Correlation between neuropathology and [F-18]FDDNP-PET binding patterns was performed using Spearman rank-order correlation. Mood, behavioral, motor, and cognitive changes were consistent with chronic traumatic myeloencephalopathy with a 22-yr lifetime risk exposure to American football. There were tau, amyloid, and TDP-43 neuropathological substrates in the brain with a differential topographically selective distribution. [F-18]FDDNP-PET binding levels correlated with brain tau deposition (rs = 0.59, P = .02), with highest relative distribution volumes in the parasagittal and paraventricular regions of the brain and the brain stem. No correlation with amyloid or TDP-43 deposition was observed. [F-18]FDDNP-PET signals may be consistent with neuropathological patterns of tau deposition in CTE, involving areas that receive the maximal shearing, angular-rotational acceleration-deceleration forces in American football players, consistent with distinctive and differential topographic vulnerability and selectivity of CTE beyond brain cortices, also involving midbrain and limbic areas. Future studies are warranted to determine whether differential and selective [F-18]FDDNP-PET may be useful in establishing a diagnosis of CTE in at-risk patients.

Published
2018

3. 477 Stereotactic Radiosurgery With Versus Without Prior Onyx Embolization for Brain Arteriovenous Malformations

Author

Chen, Ching-Jen, primary, Ding, Dale, additional, Lee, Cheng-chia, additional, Kearns, Kathryn, additional, Pomeraniec, Isaac Jonathan, additional, Cifarelli, Christopher Paul, additional, Liscak, Roman, additional, May, Jaromir, additional, Williams, Brian Jeremy, additional, Ironside, Natasha, additional, Burke, Rebecca M., additional, Warnick, Ronald E., additional, Trifiletti, Daniel M., additional, Mathieu, David, additional, Kondziolka, Douglas, additional, Feliciano, Caleb E., additional, Rodriguez-Mercado, Rafael, additional, Cockroft, Kevin M., additional, Simon, Scott Douglas, additional, Lee, John Y.K., additional, and Sheehan, Jason P., additional

Published
2023
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5. International Tuberculum Sellae Meningioma Study: Preoperative Grading Scale to Predict Outcomes and Propensity-Matched Outcomes by Endonasal Versus Transcranial Approach

Author

Magill, Stephen T., Schwartz, Theodore H., Couldwell, William T., Gardner, Paul A., Heilman, Carl B., Sen, Chandranath, Akagami, Ryojo, Cappabianca, Paolo, Prevedello, Daniel M., McDermott, Michael W., Przybylowski, Colin J., Almefty, Kaith K., Patel, Akash J., Khan, A. Basit, Wu, Kyle C., Bi, Wenya Linda, Dunn, Ian F., Mamelak, Adam N., Ehsan, Mohammad U., Bruce, Jeffrey N., Englander, Zachary K., Wang, Linda M., Youngerman, Brett, Anand, Vijay K., Kacker, Ashutosh, Tabaee, Abtin, Clarke, David B., Walling, Simon A., Hebb, Andrea L. O., Macki, Mohamed, Anand, Sharath K., Rock, Jack P., Baskin, David S., Yewah Gwei, Larisse K., Guthikonda, Bharat, Kosty, Jennifer, Nanda, Anil, Sun, Hai, Culicchia, Frank, Morrow, Kevin, Fannin, Erin, Germanwala, Anand V., Prabhu, Vikram C., Patel, Chirag R., Chaichana, Kaisorn, Quinones-Hinojosa, Alfredo, ReFaey, Karim, Chandler, James P., Fernandez, Luis G., Oyon, Daniel E., Youngblood, Mark W., Golfinos, John G., Placantonakis, Dimitris G., Pacione, Donato, Delavari, Nader, Albonette-Felicio, Thiago, Otto, Bradley A., Carrau, Ricardo L., Han, Seunggu J., Shahin, Maryam N., Brahimaj, Bledi C., Beer-Furlan, André, Byrne, Richard W., Munich, Stephan A., Munoz, Lorenzo F., Liu, James K., Zhao, Kevin, Agarwalla, Pankaj K., Hsueh, Wayne D., Eloy, Jean Anderson, Chang, Steven D., Meola, Antonio, Teng, Hao, Goulart, Carlos R., Rai, Shawn S., Chin, Lawrence S., Ahye, Nicholas, Weaver, Michael, Mangham, William M., Michael, L. Madison, Robertson, Jon H., Dowd, Richard S., Amenta, Peter S., Scullen, Tyler A., de Divitiis, Oreste, Solari, Domenico, Cavallo, Luigi M., Makarenko, Serge, Rizzuto, Michael, Prakash, Swetha, Chen, William C., El-Sayed, Ivan H., Nguyen, Minh P., Morshed, Ramin A., Theodosopoulos, Philip V., Aghi, Manish K., Santarius, Thomas, Stastna, Daniela, Williams, Brian J., Andaluz, Norberto, Adappa, Nithin D., Palmer, James N., Grady, M. Sean, Lee, John Y. K., Buch, Love, Sharma, Nikhil, Joshi, Disha, Champagne, Pierre-Olivier, Valappil, Benita, Kumar, Jay I., Agarwalla, Pankaj K., Agazzi, Siviero, van Loveren, Harry, Zada, Gabriel, Strickland, Benjamin, Garrett, Norman E., Plitt, Aaron R., Barnett, Samuel L., Mickey, Bruce E., Garzon-Muvdi, Tomas, Nassiri, Farshad, Gentili, Fred, Kalyvas, Aristotelis, Zadeh, Gelareh, Karsy, Michael, Sayyahmelli, Sima, Baskaya, Mustafa K., Morone, Peter J., Cavallo, Claudio, Sylvester, Peter T., and Chicoine, Michael R.

Published
2023
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6. International Tuberculum Sellae Meningioma Study: Surgical Outcomes and Management Trends

Author

Magill, Stephen T., Schwartz, Theodore H., Couldwell, William T., Gardner, Paul A., Heilman, Carl B., Sen, Chandranath, Akagami, Ryojo, Cappabianca, Paolo, Prevedello, Daniel M., McDermott, Michael W., Przybylowski, Colin J., Almefty, Kaith K., Patel, Akash J., Khan, A. Basit, Wu, Kyle C., Bi, Wenya Linda, Dunn, Ian F., Mamelak, Adam N., Ehsan, Mohammad U., Bruce, Jeffrey N., Englander, Zachary K., Wang, Linda M., Youngerman, Brett, Anand, Vijay K., Kacker, Ashutosh, Tabaee, Abtin, Clarke, David B., Walling, Simon A., Hebb, Andrea L. O., Macki, Mohamed, Anand, Sharath K., Rock, Jack P., Baskin, David S., Yewah Gwei, Larisse K., Guthikonda, Bharat, Kosty, Jennifer, Nanda, Anil, Sun, Hai, Culicchia, Frank, Morrow, Kevin, Fannin, Erin, Germanwala, Anand V., Prabhu, Vikram C., Patel, Chirag R., Chaichana, Kaisorn, Quinones-Hinojosa, Alfredo, ReFaey, Karim, Chandler, James P., Fernandez, Luis G., Oyon, Daniel E., Youngblood, Mark W., Golfinos, John G., Placantonakis, Dimitris G., Pacione, Donato, Delavari, Nader, Albonette-Felicio, Thiago, Otto, Bradley A., Carrau, Ricardo L., Han, Seunggu J., Shahin, Maryam N., Brahimaj, Bledi C., Beer-Furlan, André, Byrne, Richard W., Munich, Stephan A., Munoz, Lorenzo F., Liu, James K., Zhao, Kevin, Agarwalla, Pankaj K., Hsueh, Wayne D., Eloy, Jean Anderson, Chang, Steven D., Meola, Antonio, Teng, Hao, Goulart, Carlos R., Rai, Shawn S., Chin, Lawrence S., Ahye, Nicholas, Weaver, Michael, Mangham, William M., Michael, L. Madison, Robertson, Jon H., Dowd, Richard S., Amenta, Peter S., Scullen, Tyler A., de Divitiis, Oreste, Solari, Domenico, Cavallo, Luigi M., Makarenko, Serge, Rizzuto, Michael, Prakash, Swetha, Chen, William C., El-Sayed, Ivan H., Nguyen, Minh P., Morshed, Ramin A., Theodosopoulos, Philip V., Aghi, Manish K., Santarius, Thomas, Stastna, Daniela, Williams, Brian J., Andaluz, Norberto, Adappa, Nithin D., Palmer, James N., Grady, M. Sean, Lee, John Y. K., Buch, Love, Sharma, Nikhil, Joshi, Disha, Champagne, Pierre-Olivier, Valappil, Benita, Kumar, Jay I., Agarwalla, Pankaj K., Agazzi, Siviero, van Loveren, Harry, Zada, Gabriel, Strickland, Benjamin, Garrett, Norman E., Plitt, Aaron R., Barnett, Samuel L., Mickey, Bruce E., Garzon-Muvdi, Tomas, Nassiri, Farshad, Gentili, Fred, Kalyvas, Aristotelis, Zadeh, Gelareh, Neurosurgery, Division of, Hospital, Toronto Western, Toronto, University of, Toronto, Ontario, Karsy, Canada; Michael, Sayyahmelli, Sima, Baskaya, Mustafa K., Morone, Peter J., Cavallo, Claudio, Sylvester, Peter T., and Chicoine, Michael R.

Published
2023
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7. 300 Stereotactic Radiosurgery With Versus Without Embolization for Brain Arteriovenous Malformations

Author

Chen, Ching-Jen, primary, Ding, Dale, additional, Lee, Cheng-chia, additional, Kearns, Kathryn, additional, Pomeraniec, Isaac J., additional, Ironside, Natasha, additional, Kondziolka, Douglas S., additional, Trifiletti, Daniel M., additional, Liscak, Roman, additional, Cockroft, Kevin M., additional, Lee, John Y. K., additional, and Sheehan, Jason P., additional

Published
2022
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8. Stereotactic Radiosurgery With Versus Without Embolization for Brain Arteriovenous Malformations

Author

Chen, Ching-Jen, primary, Ding, Dale, additional, Lee, Cheng-Chia, additional, Kearns, Kathryn N, additional, Pomeraniec, I Jonathan, additional, Cifarelli, Christopher P, additional, Arsanious, David E, additional, Liscak, Roman, additional, Hanuska, Jaromir, additional, Williams, Brian J, additional, Yusuf, Mehran B, additional, Woo, Shiao Y, additional, Ironside, Natasha, additional, Warnick, Ronald E, additional, Trifiletti, Daniel M, additional, Mathieu, David, additional, Mureb, Monica, additional, Benjamin, Carolina, additional, Kondziolka, Douglas, additional, Feliciano, Caleb E, additional, Rodriguez-Mercado, Rafael, additional, Cockroft, Kevin M, additional, Simon, Scott, additional, Mackley, Heath B, additional, Zammar, Samer, additional, Patel, Neel T, additional, Padmanaban, Varun, additional, Beatson, Nathan, additional, Saylany, Anissa, additional, Lee, John, additional, and Sheehan, Jason P, additional

Published
2021
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9. Embolization of Brain Arteriovenous Malformations With Versus Without Onyx Before Stereotactic Radiosurgery

Author

Chen, Ching-Jen, primary, Ding, Dale, additional, Lee, Cheng-Chia, additional, Kearns, Kathryn N, additional, Pomeraniec, I Jonathan, additional, Cifarelli, Christopher P, additional, Arsanious, David E, additional, Liscak, Roman, additional, Hanuska, Jaromir, additional, Williams, Brian J, additional, Yusuf, Mehran B, additional, Woo, Shiao Y, additional, Ironside, Natasha, additional, Warnick, Ronald E, additional, Trifiletti, Daniel M, additional, Mathieu, David, additional, Mureb, Monica, additional, Benjamin, Carolina, additional, Kondziolka, Douglas, additional, Feliciano, Caleb E, additional, Rodriguez-Mercado, Rafael, additional, Cockroft, Kevin M, additional, Simon, Scott, additional, Mackley, Heath B, additional, Zammar, Samer G, additional, Patel, Neel T, additional, Padmanaban, Varun, additional, Beatson, Nathan, additional, Saylany, Anissa, additional, Lee, John, additional, and Sheehan, Jason P, additional

Published
2021
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12. Combined Fluorescence-Guided Surgery and Photodynamic Therapy for Glioblastoma Multiforme Using Cyanine and Chlorin Nanocluster

Author

Teng, Clare W, primary, Amirshaghaghi, Ahmad, additional, Cho, Steve S, additional, Cai, Shuting, additional, De Ravin, Emma, additional, Singh, Yash, additional, Miller, Joann, additional, Sheikh, Saad, additional, Delikatny, Jim, additional, Cheng, Zhiliang, additional, Busch, Theresa, additional, Singhal, Sunil, additional, Dorsey, Jay, additional, Tsourkas, Andrew, additional, and Lee, John Y.K, additional

Published
2020
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15. Stereotactic Radiosurgery for Cavernous Sinus Versus Noncavernous Sinus Dural Arteriovenous Fistulas

Author

Hung, Yi-Chieh, primary, Mohammed, Nasser, additional, Kearns, Kathryn N, additional, Chen, Ching-Jen, additional, Starke, Robert M, additional, Kano, Hideyuki, additional, Lee, John, additional, Mathieu, David, additional, Kaufmann, Anthony M, additional, Wang, Wei Gang, additional, Grills, Inga S, additional, Cifarelli, Christopher P, additional, Vargo, John, additional, Chytka, Tomas, additional, Janouskova, Ladislava, additional, Feliciano, Caleb E, additional, Rodriguez-Mercado, Rafael, additional, Lunsford, L Dade, additional, and Sheehan, Jason P, additional

Published
2020
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18. A Proposed Grading Scale for Predicting Outcomes After Stereotactic Radiosurgery for Dural Arteriovenous Fistulas

Author

Mohammed, Nasser, primary, Hung, Yi-Chieh, additional, Chen, Ching-Jen, additional, Xu, Zhiyuan, additional, Schlesinger, David, additional, Kano, Hideyuki, additional, Chiang, Veronica, additional, Hess, Judith, additional, Lee, John, additional, Mathieu, David, additional, Kaufmann, Anthony M, additional, Grills, Inga S, additional, Cifarelli, Christopher P, additional, Vargo, John A, additional, Chytka, Tomas, additional, Janouskova, Ladislava, additional, Feliciano, Caleb E, additional, Mercado, Rafael Rodriguez, additional, Lunsford, L Dade, additional, and Sheehan, Jason P, additional

Published
2019
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23. Association of Surgical Overlap during Wound Closure with Patient Outcomes among Neurological Surgery Patients at a Large Academic Medical Center

Author

Glauser, Gregory, primary, Agarwal, Prateek, additional, Ramayya, Ashwin G, additional, Chen, H Isaac, additional, Lee, John Y K, additional, Schuster, James M, additional, Osiemo, Benjamin, additional, Goodrich, Stephen, additional, Smith, Lachlan J, additional, McClintock, Scott D, additional, and Malhotra, Neil R, additional

Published
2019
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24. Stereotactic Radiosurgery for Trigeminal Neuralgia in Patients With Multiple Sclerosis

Author

Xu, Zhiyuan, primary, Mathieu, David, additional, Heroux, France, additional, Abbassy, Mahmoud, additional, Barnett, Gene, additional, Mohammadi, Alireza M, additional, Kano, Hideyuki, additional, Caruso, James, additional, Shih, Han-Hsun, additional, Grills, Inga S, additional, Lee, Kuei, additional, Krishnan, Sandeep, additional, Kaufmann, Anthony M, additional, Lee, John Y K, additional, Alonso-Basanta, Michelle, additional, Kerr, Marie, additional, Pierce, John, additional, Kondziolka, Douglas, additional, Hess, Judith A, additional, Gerrard, Jason, additional, Chiang, Veronica, additional, Lunsford, L Dade, additional, and Sheehan, Jason P, additional

Published
2019
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25. A Proposed Grading Scale for Predicting Outcomes After Stereotactic Radiosurgery for Dural Arteriovenous Fistulas.

Author

Mohammed, Nasser, Hung, Yi-Chieh, Chen, Ching-Jen, Xu, Zhiyuan, Schlesinger, David, Kano, Hideyuki, Chiang, Veronica, Hess, Judith, Lee, John, Mathieu, David, Kaufmann, Anthony M, Grills, Inga S, Cifarelli, Christopher P, Vargo, John A, Chytka, Tomas, Janouskova, Ladislava, Feliciano, Caleb E, Mercado, Rafael Rodriguez, Lunsford, L Dade, and Sheehan, Jason P

Published
2020
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28. Stereotactic Radiosurgery for Acromegaly: An International Multicenter Retrospective Cohort Study

Author

Ding, Dale, primary, Mehta, Gautam U, additional, Patibandla, Mohana Rao, additional, Lee, Cheng-Chia, additional, Liscak, Roman, additional, Kano, Hideyuki, additional, Pai, Fu-Yuan, additional, Kosak, Mikulas, additional, Sisterson, Nathaniel D, additional, Martinez-Alvarez, Roberto, additional, Martinez-Moreno, Nuria, additional, Mathieu, David, additional, Grills, Inga S, additional, Blas, Kevin, additional, Lee, Kuei, additional, Cifarelli, Christopher P, additional, Katsevman, Gennadiy A, additional, Lee, John Y K, additional, McShane, Brendan, additional, Kondziolka, Douglas, additional, Lunsford, L Dade, additional, Vance, Mary Lee, additional, and Sheehan, Jason P, additional

Published
2018
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29. Postmortem Autopsy-Confirmation of Antemortem [F-18]FDDNP-PET Scans in a Football Player With Chronic Traumatic Encephalopathy

Author

Omalu, Bennet, primary, Small, Gary W, additional, Bailes, Julian, additional, Ercoli, Linda M, additional, Merrill, David A, additional, Wong, Koon-Pong, additional, Huang, Sung-Cheng, additional, Satyamurthy, Nagichettiar, additional, Hammers, Jennifer L, additional, Lee, John, additional, Fitzsimmons, Robert P, additional, and Barrio, Jorge R, additional

Published
2017
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30. 362 Outcomes of Stereotactic Radiosurgery for Foramen Magnum Meningiomas: An International Multicenter Study

Author

Mehta, Gautam U, primary, Zenonos, Georgios A, additional, Patibandla, Mohana Rao, additional, Lin, Chung Jung, additional, Wolf, Amparo M, additional, Grills, Inga S, additional, Mathieu, David, additional, McShane, Brendan, additional, Lee, John Y K, additional, Blas, Kevin, additional, Kondziolka, Douglas, additional, Lee, Cheng-Chia, additional, Lunsford, L Dade, additional, and Sheehan, Jason P, additional

Published
2017
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31. 104 Stereotactic Radiosurgery for Spetzler-Martin Grade IV and V Arteriovenous Malformations: An International Multicenter Study

Author

Sheehan, Jason P, primary, Patibandla, Mohana Rao, additional, Ding, Dale, additional, Kano, Hideyuki, additional, Xu, Zhiyuan, additional, Lee, John Y K, additional, Feliciano, Caleb E, additional, Kondziolka, Douglas, additional, Grills, Inga S, additional, Barnett, Gene H, additional, and Lunsford, L Dade, additional

Published
2017
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32. Radiosurgery for Unruptured Brain Arteriovenous Malformations: An International Multicenter Retrospective Cohort Study

Author

Ding, Dale, primary, Starke, Robert M., additional, Kano, Hideyuki, additional, Lee, John Y.K., additional, Mathieu, David, additional, Pierce, John, additional, Huang, Paul, additional, Missios, Symeon, additional, Feliciano, Caleb, additional, Rodriguez-Mercado, Rafael, additional, Almodovar, Luis, additional, Grills, Inga S., additional, Silva, Danilo, additional, Abbassy, Mahmoud, additional, Kondziolka, Douglas, additional, Barnett, Gene H., additional, Lunsford, L. Dade, additional, and Sheehan, Jason P., additional

Published
2017
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35. Stereotactic Radiosurgery for Acromegaly: An International Multicenter Retrospective Cohort Study.

Author

Ding, Dale, Mehta, Gautam U, Patibandla, Mohana Rao, Lee, Cheng-Chia, Liscak, Roman, Kano, Hideyuki, Pai, Fu-Yuan, Kosak, Mikulas, Sisterson, Nathaniel D, Martinez-Alvarez, Roberto, Martinez-Moreno, Nuria, Mathieu, David, Grills, Inga S, Blas, Kevin, Lee, Kuei, Cifarelli, Christopher P, Katsevman, Gennadiy A, Lee, John Y K, McShane, Brendan, and Kondziolka, Douglas

Published
2019
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38. Gamma Knife Radiosurgery for Cerebellopontine Angle Meningiomas

Author

Ding, Dale, primary, Starke, Robert M., additional, Kano, Hideyuki, additional, Nakaji, Peter, additional, Barnett, Gene H., additional, Mathieu, David, additional, Chiang, Veronica, additional, Omay, Sacit B., additional, Hess, Judith, additional, McBride, Heyoung L., additional, Honea, Norissa, additional, Lee, John Y.K., additional, Rahmathulla, Gazanfar, additional, Evanoff, Wendi A., additional, Alonso-Basanta, Michelle, additional, Lunsford, L. Dade, additional, and Sheehan, Jason P., additional

Published
2014
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40. 179 Brief Pain Inventory-Facial

Author

Halpern, Casey H., primary, Sandhu, Sukhmeet, additional, Vakhshori, Venus BS, additional, Mirsaeedi-Farahani, Keyvan, additional, Kerr, Marie, additional, and Lee, John YK., additional

Published
2013
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45. Stereotactic Radiosurgery With Versus Without Neoadjuvant Endovascular Embolization for Brain Arteriovenous Malformations With Associated Intracranial Aneurysms.

Author

Becerril-Gaitan A, Nguyen J, Lee CC, Ding D, Cifarelli CP, Liscak R, Williams BJ, Yusuf MB, Woo SY, Warnick RE, Trifiletti DM, Mathieu D, Kondziolka D, Feliciano CE, Rodriguez-Mercado R, Cockroft KM, Simon S, Lee J, Sheehan JP, and Chen CJ

Abstract

Background and Objectives: Stereotactic radiosurgery (SRS) with neoadjuvant embolization is a treatment strategy for brain arteriovenous malformations (AVMs), especially for those with large nidal volume or concomitant aneurysms. The aim of this study was to assess the effects of pre-SRS embolization in AVMs with an associated intracranial aneurysm (IA)., Methods: The International Radiosurgery Research Foundation AVM database from 1987 to 2018 was retrospectively reviewed. SRS-treated AVMs with IAs were included. Patients were categorized into those treated with upfront embolization (E + SRS) vs stand-alone SRS (SRS). Primary end point was a favorable outcome (AVM obliteration + no permanent radiation-induced changes or post-SRS hemorrhage). Secondary outcomes included AVM obliteration, mortality, follow-up modified Rankin Scale, post-SRS hemorrhage, and radiation-induced changes., Results: Forty four AVM patients with associated IAs were included, of which 23 (52.3%) underwent pre-SRS embolization and 21 (47.7%) SRS only. Significant differences between the E + SRS vs SRS groups were found for AVM maximum diameter (1.5 ± 0.5 vs 1.1 ± 0.4 cm3, P = .019) and SRS treatment volume (9.3 ± 8.3 vs 4.3 ± 3.3 cm3, P = .025). A favorable outcome was achieved in 45.4% of patients in the E + SRS group and 38.1% in the SRS group (P = .625). Obliteration rates were comparable (56.5% for E + SRS vs 47.6% for SRS, P = .555), whereas a higher mortality rate was found in the SRS group (19.1% vs 0%, P = .048). After adjusting for AVM maximum diameter, SRS treatment volume, and maximum radiation dose, the likelihood of achieving favorable outcome and AVM obliteration did not differ between groups (P = .475 and P = .820, respectively)., Conclusion: The likelihood of a favorable outcome and AVM obliteration after SRS with neoadjuvant embolization in AVMs with concomitant IA seems to be comparable with stand-alone SRS, even after adjusting for AVM volume and SRS maximum dose. However, the increased mortality among the stand-alone SRS group and relatively low risk of embolization-related complications suggest that these patients may benefit from a combined treatment approach., (Copyright © Congress of Neurological Surgeons 2024. All rights reserved.)

Published
2024
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