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Your search keyword '"Tamo, Wakako"' showing total 4 results
Start Over Author "Tamo, Wakako" Journal neuroscience letters
4 results on '"Tamo, Wakako"'

3. Synergistic stimulation, by tumor necrosis factor-α and interferon-γ, of fractalkine expression in human astrocytes

Author

Yoshida, Hidemi, primary, Imaizumi, Tadaatsu, additional, Fujimoto, Koji, additional, Matsuo, Naomi, additional, Kimura, Kazuyuki, additional, Cui, Xue-Fan, additional, Matsumiya, Tomoh, additional, Tanji, Kunikazu, additional, Shibata, Takeo, additional, Tamo, Wakako, additional, Kumagai, Mika, additional, and Satoh, Kei, additional

Published
2001
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4. Expression of alpha-synuclein, the precursor of non-amyloid beta component of Alzheimer's disease amyloid, in human cerebral blood vessels.

Author

Tamo W, Imaizumi T, Tanji K, Yoshida H, Mori F, Yoshimoto M, Takahashi H, Fukuda I, Wakabayashi K, and Satoh K

Subjects
Aged, Aged, 80 and over, Alzheimer Disease metabolism, Autopsy, Blotting, Northern, Blotting, Western, Cell Culture Techniques, Cerebral Amyloid Angiopathy pathology, Fluorescent Antibody Technique, Gene Expression Regulation, Humans, Hydrogen Peroxide pharmacology, Immunohistochemistry, Middle Aged, Nerve Tissue Proteins genetics, Nerve Tissue Proteins immunology, RNA, Messenger analysis, Reverse Transcriptase Polymerase Chain Reaction, Synucleins, Time Factors, alpha-Synuclein, Cerebral Amyloid Angiopathy metabolism, Cerebral Arteries chemistry, Cerebral Arteries pathology, Nerve Tissue Proteins analysis
Abstract

The non-amyloid beta component of Alzheimer's disease amyloid (NAC) is detected in cerebral amyloid angiopathy; and the precursor of NAC is now known to be identical to alpha-synuclein (alpha-S), a major component of Lewy bodies in Parkinson's disease. We studied if cerebral vascular cells express alpha-S. Immunohistochemical studies of human cerebral tissues from control and cerebral amyloid angiopathy patients revealed the expression of alpha-S in vascular endothelial and smooth muscle cells. Then we studied the expression of alpha-S in vitro using cultures of vascular cells. Cultures of human umbilical vein endothelial cells and umbilical artery smooth muscle cells were found to constitutively express alpha-S messenger RNA and protein. alpha-S is normally expressed in vascular cells and may play some physiological role in the vascular wall.

Published
2002
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