1. Chronic immobilization stress induces anxiety- and depression-like behaviors and decreases transthyretin in the mouse cortex
- Author
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Young Hyurk Lee, Wan Sung Choi, Yeon Hee Joo, Sang Soo Kang, Gu Seob Roh, Gyeongwha Kim, Gyeong Jae Cho, Hyun Joon Kim, Dong Hoon Lee, and Kyung Mi Choi
- Subjects
Male ,medicine.medical_specialty ,Ratón ,Anxiety ,Immobilization ,Mice ,Internal medicine ,Cortex (anatomy) ,Gene expression ,medicine ,Animals ,Prealbumin ,Chronic stress ,Cerebral Cortex ,Mice, Inbred ICR ,Behavior, Animal ,biology ,Depression ,Microarray analysis techniques ,General Neuroscience ,Fold change ,Transthyretin ,Endocrinology ,medicine.anatomical_structure ,Chronic Disease ,biology.protein ,Choroid plexus ,sense organs ,Stress, Psychological ,Genome-Wide Association Study - Abstract
In this study, we examined the changes in gene expression in the mouse cortex following chronic stress and behavioral tests. Mice were subjected to immobilization stress for 2 h per day for 15 consecutive days and the behavior of the mice was examined. The mice in the experimental group were more anxious and depressive than the control mice. The expression of mRNA in the cortex was analyzed by microarray analysis and 63 genes were found to show a greater than twofold change in expression between the control and experimental groups. Transthyretin was further investigated because its expression showed the greatest fold change. Transthyretin mRNA expression decreased in a chronic stress-specific manner, and protein levels were reduced in the cortex but not in the choroid plexus.
- Published
- 2009
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