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Start Over Descriptor "spatiotemporal map" Journal neuroscience
2 results on '"spatiotemporal map"'

1. “The developmental and functional logic of neuronal circuits”: commentary on the Kavli Prize in Neuroscience

Author

Glover, J.C.

Subjects
*NEURAL circuitry, *NEUROSCIENCE conferences, *CEREBRAL cortex, *BRAIN anatomy, *DEVELOPMENTAL neurobiology, *MOLECULAR neurobiology, *NEURAL transmission
Abstract

Abstract: The first Kavli Prize in Neuroscience recognizes a confluence of career achievements that together provide a fundamental understanding of how brain and spinal cord circuits are assembled during development and function in the adult. The members of the Kavli Neuroscience Prize Committee have decided to reward three scientists (Sten Grillner, Thomas Jessell, and Pasko Rakic) jointly “for discoveries on the developmental and functional logic of neuronal circuits”. Pasko Rakic performed groundbreaking studies of the developing cerebral cortex, including the discovery of how radial glia guide the neuronal migration that establishes cortical layers and for the radial unit hypothesis and its implications for cortical connectivity and evolution. Thomas Jessell discovered molecular principles governing the specification and patterning of different neuron types and the development of their synaptic interconnection into sensorimotor circuits. Sten Grillner elucidated principles of network organization in the vertebrate locomotor central pattern generator, along with its command systems and sensory and higher order control. The discoveries of Rakic, Jessell and Grillner provide a framework for how neurons obtain their identities and ultimate locations, establish appropriate connections with each other, and how the resultant neuronal networks operate. Their work has significantly advanced our understanding of brain development and function and created new opportunities for the treatment of neurological disorders. Each has pioneered an important area of neuroscience research and left a legacy of exceptional scientific achievement, insight, communication, mentoring and leadership. [Copyright &y& Elsevier]

Published
2009
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2. 'The developmental and functional logic of neuronal circuits': commentary on the Kavli Prize in Neuroscience

Author

Joel C. Glover

Subjects
amyotrophic lateral sclerosis, ocular dominance columns, hox genes, striatum, Awards and Prizes, lamprey, supraspinal centers, primate, sensorimotor circuits, motoneuron pools, mammalian, informatics, opiates, swimming, ependyma, axonal pathfinding, Neurons, histogenesis, commissural interneurons, neuromechanical model, radial unit hypothesis, locomotor, Central pattern generator, notochord, shh, spatiotemporal map, last mitotic division, locomotion, neurogenesis, embryonic development, cerebral cortex, vestibulospinal, excitatory aminoacid, stretch reflex, Brain development, anatomy, Neuroscience(all), Neuronal migration, muscle spindles, cat, hybridoma, chemotropic, Order control, sonic hedgehog, network organization, cytoarchitectonic, Humans, human, dorsoventral patterning, bistable membrane, goal-directed behavior, Sweden, fish, spinal cord, History, 20th Century, United States, central pattern generator, sensory neurons, Neuronal circuits, Synapses, surface molecules, Neuroscience, recognition molecules, Scientific achievement, “migration disorders”, substance P, radial glia, capsaicin, Neuron types, tritiated thymidine, neuronal identity, signaling gradient, Neural Pathways, rhythmicity, motor control, sensory transmitters, pain, adhesion molecules, neuronal migration, General Neuroscience, Neuroinformatics, proliferative unit, connectivity, monoclonal antibodies, monkey, laser scanning confocal microscopy, brain anatomy, retionoic acid, Grillner S, neuronal progenitors, molecular markers, floor plate, sensorimotor reflex circuits, molecular specification of neurons, nerve fiber trajectories, Motor Activity, Biology, History, 21st Century, NMDA receptors, motoneuron diseases, evolution, computer simulation, Animals, Jessell TM, prot-map, Neurosciences, cortical layers, epitopes, electrophysiology, neuroinformatics, fictive locomotion, spinal cord injury, Rakic P, acetylcholine receptors, Perception, nuclear transcription factors, anteroposterior patterning, reticulospinal
Abstract

The first Kavli Prize in Neuroscience recognizes a confluence of career achievements that together provide a fundamental understanding of how brain and spinal cord circuits are assembled during development and function in the adult. The members of the Kavli Neuroscience Prize Committee have decided to reward three scientists (Sten Grillner, Thomas Jessell, and Pasko Rakic) jointly “for discoveries on the developmental and functional logic of neuronal circuits”.Pasko Rakic performed groundbreaking studies of the developing cerebral cortex, including the discovery of how radial glia guide the neuronal migration that establishes cortical layers and for the radial unit hypothesis and its implications for cortical connectivity and evolution.Thomas Jessell discovered molecular principles governing the specification and patterning of different neuron types and the development of their synaptic interconnection into sensorimotor circuits.Sten Grillner elucidated principles of network organization in the vertebrate locomotor central pattern generator, along with its command systems and sensory and higher order control.The discoveries of Rakic, Jessell and Grillner provide a framework for how neurons obtain their identities and ultimate locations, establish appropriate connections with each other, and how the resultant neuronal networks operate. Their work has significantly advanced our understanding of brain development and function and created new opportunities for the treatment of neurological disorders. Each has pioneered an important area of neuroscience research and left a legacy of exceptional scientific achievement, insight, communication, mentoring and leadership.

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