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Your search keyword '"Tabuchi, Akiko"' showing total 5 results
Start Over Author "Tabuchi, Akiko" Journal neuroreport
5 results on '"Tabuchi, Akiko"'

4. Activity-dependent increase in -amyloid precursor protein mRNA expression in neurons

Author

Tabuchi, Akiko, Ishii, Asami, Fukuchi, Mamoru, Kobayashi, Sachiyo, Suzuki, Toshiharu, and Tsuda, Masaaki

Abstract

Although -amyloid precursor protein (APP) has been suggested to play a role in neuronal survival and plasticity, the mRNA expression of APP has not been studied in terms of neuronal activity. In cultures of mouse cerebellar granule cells, we found that the levels of APP mRNA increased when a high concentration of potassium was present in the medium. A deprivation of membrane depolarization caused by lowering the Kconcentration decreased both mRNA expression and protein synthesis of APP. Increasing the concentration, however, restored mRNA expression, which was driven by the influx of Ca2through L-type voltage-dependent calcium channels and mediated by de novoprotein synthesis. Thus, APP mRNA expression is controlled in an activity-dependent manner in neurons.

Published
2004
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5. Activity-dependent increase in beta-amyloid precursor protein mRNA expression in neurons.

Author

Tabuchi A, Ishii A, Fukuchi M, Kobayashi S, Suzuki T, and Tsuda M

Subjects
Amyloid beta-Protein Precursor biosynthesis, Animals, Brain cytology, Calcium metabolism, Calcium Channel Blockers pharmacology, Calcium Channels, L-Type drug effects, Calcium Channels, L-Type metabolism, Calcium Signaling drug effects, Cells, Cultured, Membrane Potentials drug effects, Membrane Potentials genetics, Mice, Mice, Inbred ICR, Neurons cytology, Neurons drug effects, Potassium Chloride metabolism, Potassium Chloride pharmacology, Protein Synthesis Inhibitors pharmacology, RNA, Messenger drug effects, Amyloid beta-Protein Precursor genetics, Brain metabolism, Calcium Signaling genetics, Neurons metabolism, RNA, Messenger metabolism
Abstract

Although beta-amyloid precursor protein (APP) has been suggested to play a role in neuronal survival and plasticity, the mRNA expression of APP has not been studied in terms of neuronal activity. In cultures of mouse cerebellar granule cells, we found that the levels of APP mRNA increased when a high concentration of potassium was present in the medium. A deprivation of membrane depolarization caused by lowering the K+ concentration decreased both mRNA expression and protein synthesis of APP. Increasing the concentration, however, restored mRNA expression, which was driven by the influx of Ca2+ through L-type voltage-dependent calcium channels and mediated by de novo protein synthesis. Thus, APP mRNA expression is controlled in an activity-dependent manner in neurons., (Copyright 2004 Lippincott Williams and Wilkins)

Published
2004
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