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Your search keyword '"Segman, R. H."' showing total 2 results
Start Over Author "Segman, R. H." Journal neuroreport
2 results on '"Segman, R. H."'

1. Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia

Author

Bah, J., primary, Quach, H., additional, Ebstein, R. P., additional, Segman, R. H., additional, Melke, J., additional, Jamain, S., additional, Rietschel, M., additional, Modai, I., additional, Kanas, K., additional, Karni, O., additional, Lerer, B., additional, Gourion, D., additional, Krebs, M. O., additional, Etain, B., additional, Schürhoff, F., additional, Szöke, A., additional, Leboyer, M., additional, and Bourgeron, T., additional

Published
2004
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2. Maternal transmission disequilibrium of the glutamate receptor GRIK2in schizophrenia

Author

Bah, J., Quach, H., Ebstein, R. P., Segman, R. H., Melke, J., Jamain, S., Rietschel, M., Modai, I., Kanas, K., Karni, O., Lerer, B., Gourion, D., Krebs, M. O., Etain, B., Schürhoff, F., Szöke, A., Leboyer, M., and Bourgeron, T.

Abstract

Schizophrenia is characterized by thought disorders, hallucinations and delusions. Genetic studies have shown a high linkage at chromosome 6q16-21. Among the genes located in this region is the glutamate receptor ionotropic kainate 2 gene (GRIK2or GLUR6), a functional candidate for susceptibility to schizophrenia. In this study, transmission of GRIK2was evaluated in 356 schizophrenic patients from three different clinical centers. Whereas paternal transmission shows equilibrium, we observed maternal transmission disequilibrium of GRIK2in the largest population (p0.03), which was still significant when all populations were added (p0.05). These results are similar to the maternal GRIK2transmission disequilibrium previously reported for autism, and support the presence of a susceptibility gene for schizophrenia at 6q16.

Published
2004

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