1. Centrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in mice
- Author
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Ikuo Kato, Minglun Tsai, Koji Ataka, Akio Inui, Akihiro Asakawa, Miharu Ushikai, Kaori Atsuchi, Ken-Ichiro Koyama, Yuki Sato, and Mineko Fujimiya
- Subjects
medicine.medical_specialty ,Ratón ,Motility ,Nerve Tissue Proteins ,Biology ,Mice ,Calcium-binding protein ,Internal medicine ,medicine ,Animals ,Nucleobindins ,Gastroduodenal motility ,Antrum ,Injections, Intraventricular ,General Neuroscience ,Calcium-Binding Proteins ,digestive, oral, and skin physiology ,Feeding Behavior ,Nucleobindin 2 ,DNA-Binding Proteins ,Mice, Inbred C57BL ,Endocrinology ,Hypothalamus ,Anorectic ,Female ,Gastrointestinal Motility - Abstract
Nesfatin-1 was recently identified as a peptide with anorexigenic effects that is localized in the hypothalamus and adipocytes. Not much is known about the effect of nesfatin-1 on gut motility. Food intake was measured after intracerebroventricular administration of nesfatin-1 in food-deprived mice. Antral and duodenal motility was assessed by using a manometric method in conscious fed mice. We found that centrally administered nesfatin-1 decreased food intake and inhibited gastroduodenal motility in mice. These results suggest that nesfatin-1 influences gut motility and feeding behaviour.
- Published
- 2010
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