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Introduction: This study was to investigate the periprocedural stroke rates, safety, and long-term effect of Wingspan stenting for symptomatic severe stenosis of the middle cerebral artery (MCA) at a high-volume center. Methods: Between July 2007 and April 2013, 196 consecutive patients with severe MCA atherosclerotic stenosis (≥70 %) who were treated with Wingspan stenting were retrospectively studied. All patients had arterial stenosis-related temporary ischemic attack or strokes. The demographic data, cerebral angiography, technical success rate, periprocedural complications, and clinical and imaging follow-up were analyzed. Results: The successful stenting rate was 98.0 %, and the stenosis rate was improved from pre-stenting (80.6 ± 8.3 %) to post-stenting (15.5 ± 6.8 %). The 30-day periprocedural stroke or death rate was 7.1 %, with a disabling or fatal rate of 2.6 %. The perioprocedural stroke rate was significantly ( P < 0.01) greater in the early learning stage (16.0 %) than in the later technical maturation stage (4.1 %). The total periprocedural ischemic and perforator stroke rates were greater in patients with the most stenosis in the distal MCA 1/3 segment (6.8 and 5.7 %, respectively) than in the proximal and middle 2/3 segments (0.9 and 0 %, respectively). The ipsilateral stroke or death rate beyond 30 days (6-69 months, mean 30 ± 16) was 4.8 %, with the 1- and 2-year cumulative stroke rates of 9.6 and 12.1 %, respectively. Imaging follow-up 6-69 months (mean 10.9 ± 8.5) revealed restenosis in 21 cases (20.4 %). Conclusion: Intracranial stenting of MCA stenoses may have the potential of better clinical outcomes if patients are properly selected and treated by an experienced operator at a high-volume center. [ABSTRACT FROM AUTHOR]