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We report on the patterns of asymmetries of various MRI-derived cortical phenotypes, namely cortical thickness (CT), cortical surface area (CSA), cortical volume (CV) and sulcal depth (SULC), as well as on their cross-relationships. A surface-based approach was designed to obtain cortical asymmetry maps unbiased for inter-hemispheric structural positional misalignment. Accurate vertex-wise asymmetries of CT, CSA, CV, and SULC were so obtained in 250 individuals including 120 left-handers that had been selected from a larger population as having a typical leftward language lateralization. We found no significant effect of handedness on CT, CSA or CV asymmetries, although a trend for a significant difference in the SULC asymmetry of the Rolandic genu was present (leftward in right-handers, rightward in left-handers). At the hemispheric level, we found rightward CT and CSA asymmetries that were not correlated. At the regional level, asymmetry patterns of CT and CSA were marked by a spatial overlap of both concordant and opposite CT and CSA asymmetries. Half of these regions of overlap presented a significant association (positive or negative) between CT and CSA asymmetries. Strikingly, the 3 regions showing positive correlations between CT and CSA asymmetries were those known to exhibit robust asymmetries across methodologies, such as the leftward asymmetrical planum temporale and the rightward asymmetrical superior temporal sulcus and cingulate cortex. This study demonstrates that regional correlations between CT and CSA asymmetries are a characteristic of brain structural organization that could be of significance in the choice of structural markers in studies dealing with the genetic basis of brain lateralization., (Copyright © 2016 Elsevier Ltd. All rights reserved.)

Cerebral lateralization for language production and spatial attention and their relationships with manual preference strength (MPS) were assessed in a sample of 293 healthy volunteers, including 151 left-handers, using fMRI during covert sentence production (PROD) and line bisection judgment (LBJ) tasks, as compared to high- and low-level reference tasks. At the group level, we found the expected complementary hemispheric specialization (HS) with leftward asymmetries for PROD within frontal and temporal regions and rightward asymmetries for LBJ within frontal and posterior occipito-parieto-temporal regions. Individual hemispheric (HLI) and regional (frontal and occipital) lateralization indices (LI) were then calculated on the activation maps for PROD and LBJ. We found a correlation between the degree of rightward cerebral asymmetry and the leftward behavioral attentional bias recorded during LBJ task. This correlation was found when LBJ-LI was computed over the hemispheres, in the frontal lobes, but not in the occipital lobes. We then investigated whether language production and spatial attention cerebral lateralization relate to each other, and whether manual preference was a variable that impacted the complementary HS of these functions. No correlation was found between spatial and language LIs in the majority of our sample of participants, including right-handers with a strong right-hand preference (sRH, n=97) and mixed-handers (MH, n=97), indicating that these functions lateralized independently. By contrast, in the group of left-handers with a strong left-hand preference (sLH, n= 99), a negative correlation was found between language and spatial lateralization. This negative correlation was found when LBJ-LI and PROD-LI were computed over the hemispheres, in the frontal lobes and between the occipital lobes for LBJ and the frontal lobes for PROD. These findings underline the importance to include sLH in the study sample to reveal the underlying mechanisms of complementary HS., (Copyright © 2015 Elsevier Ltd. All rights reserved.)