1. Behavioral and neurochemical studies on brain aging in galanin overexpressing mice
- Author
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Luca Ferraro, Tiziana Antonelli, Stefania Pirondi, Tamas Bartfai, Eugenia Kuteeva, Laura Calzà, Luciana Giardino, Tomas Hökfelt, Sven-Ove Ögren, Pirondi S., Kuteeva E., Giardino L., Ferraro L., Antonelli T., Bartfai T., Ogren S.O., Hokfelt T., and Calza L.
- Subjects
Genetically modified mouse ,Aging ,medicine.medical_specialty ,Dopamine ,Central nervous system ,Gene Expression ,Neuropeptide ,Hippocampus ,Galanin ,Mice, Transgenic ,Anxiety ,Biology ,Stress ,Tritium ,Mice ,Norepinephrine ,Cellular and Molecular Neuroscience ,Endocrinology ,Neurochemical ,Internal medicine ,medicine ,Transgenic mice ,Animals ,Behavior, Animal ,Porsolt test ,Depression ,Endocrine and Autonomic Systems ,Brain ,General Medicine ,Mice, Inbred C57BL ,Cortex ,Exploratory behavior ,medicine.anatomical_structure ,nervous system ,Neurology ,Cerebral cortex ,Exploratory Behavior ,Behavioural despair test - Abstract
To study possible involvement of galanin in brain aging quality, we have investigated behavioral, neurochemical and morphological parameters in aged mice overexpressing galanin under the platelet-derived growth factor B promoter (GalOE mice) compared to wild-type littermates (WT mice). The behavioral analysis in the forced swim test showed that old GalOE animals spent more time in immobility compared to WT. In the activity cage test, galanin overexpression counteracted the age-induced decrease in exploratory behavior. The neurochemical analysis showed a 30% decrease in noradrenaline overflow in the cerebral cortex of WT old mice that was not present in age-matched GalOE mice. Our results indicate that overexpression of galanin can influence several behavioral and neurochemical parameters in old mice.
- Published
- 2005
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