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4 results on '"I. Bougault"'

1. Activation of dopaminergic and cholinergic neurotransmission by tachykinin NK3 receptor stimulation: an in vivo microdialysis approach in guinea pig

Author

G. Le Fur, N. Marco, I. Bougault, A. Thirion, Philippe Soubrie, G. Mons, and Régis Steinberg

Subjects
Male, Time Factors, Dopamine, Microdialysis, Guinea Pigs, Prefrontal Cortex, Substantia nigra, Pharmacology, Nucleus accumbens, Substance P, Hippocampus, Synaptic Transmission, Nucleus Accumbens, Cellular and Molecular Neuroscience, Endocrinology, Piperidines, medicine, Animals, Dose-Response Relationship, Drug, Endocrine and Autonomic Systems, Chemistry, Pars compacta, Dopaminergic, Ventral Tegmental Area, Brain, Receptors, Neurokinin-3, General Medicine, Acetylcholine, Corpus Striatum, Peptide Fragments, Ventral tegmental area, Substantia Nigra, medicine.anatomical_structure, Neurology, Cholinergic, Tachykinin receptor, Neuroscience, medicine.drug
Abstract

The regulation of dopaminergic and cholinergic function by neurokinin-3 (NK3) receptor activation was examined in vivo in urethane-anaesthetized guinea pigs with microdialysis probes. The local application of the NK3 tachykinin receptor agonist senktide in the region of dopamine cell bodies (pars compacta of the substantia nigra and ventral tegmental area) and in the area of cholinergic cell bodies (septal area) markedly enhanced the extracellular dopamine (DA) and acetylcholine (ACh) concentration throughout their respective target areas, i.e. striatum, nucleus accumbens, prefrontal cortex for dopaminergic systems and hippocampus for cholinergic neurons. The enhancing effect of senktide on neurotransmitter release was dose dependently blocked by the selective non-peptide NK3 receptor antagonist SR142801 (0.1-1 mg/kg, i.p.), whereas its inactive S-enantiomer SR142806 (0.3-1 mg/kg, i.p.) did not exert any antagonistic activity on the effect of intranigral or intraseptal application of senktide. These results demonstrate that NK3 receptors can modulate the activity of central DA and ACh systems.

Published
1998

2. Neurochemical and behavioural effects of neurotensin vs [D-Tyr11]neurotensin on mesolimbic dopaminergic function

Author

Régis Steinberg, J. Souilhac, Philippe Brun, I. Bougault, G. Le Fur, Roger Leyris, and DP Soubrié

Subjects
Male, medicine.medical_specialty, Dopamine, Neuropeptide, Nucleus accumbens, complex mixtures, Nucleus Accumbens, Rats, Sprague-Dawley, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Endocrinology, Internal medicine, medicine, Animals, Neurotensin receptor, Neurotensin, Behavior, Animal, Dose-Response Relationship, Drug, Endocrine and Autonomic Systems, musculoskeletal, neural, and ocular physiology, digestive, oral, and skin physiology, Dopaminergic, Ventral Tegmental Area, Stereoisomerism, General Medicine, Thiorphan, Peptide Fragments, Rats, Ventral tegmental area, medicine.anatomical_structure, nervous system, Neurology, chemistry, hormones, hormone substitutes, and hormone antagonists, medicine.drug
Abstract

Microinjection of neurotensin(1–13) or neurotensin(8–13) into the ventral tegmental area (VTA) of anaesthetized rats produced dose-dependent (1–100 pg) dopamine release in the nucleus accumbens as measured by differential pulse amperometry (DPA). Higher doses (100 pg-10 ng) of [D-Tyr11neurotensin were required to produce an identical effect. In addition, the 3 peptides enhanced the K+-evoked [3H]DA release from nucleus accumbens slices. The stimulatory actions produced by 10−8 M neurotensin(1–13) and neurotensin(8–13) were respectively of 96% and 72% while the effect of [D-Tyr11]neurotensin was only of 79% at 10−6 M. Unilateral application of the 3 peptides in the VTA of cannulated rats produced contralateral circling. [D-Tyr11]neurotensin was effective in a dose-dependent manner, between 40 and 320 ng. Similar effects were observed with 80 ng of neurotensin(1–13) and neurotensin(8–13) in presence of the protease inhibitor thiorphan. In view of the higher potency of neurotensin(1–13) and neurotensin(8–13) versus [D-Tyr11]neurotensin to stimulate DA release both in vivo and in vitro and the higher efficacy of [D-Tyr11]neurotensin to induce circling, this study further strengthens the concept of neurotensin receptor heterogeneity.

Published
1995

3. Activation of dopaminergic and cholinergic neurotransmission by tachykinin NK3 receptor stimulation: an in vivo microdialysis approach in guinea pig.

Author

Marco N, Thirion A, Mons G, Bougault I, Le Fur G, Soubrié P, and Steinberg R

Subjects
Animals, Brain drug effects, Corpus Striatum drug effects, Corpus Striatum physiology, Dose-Response Relationship, Drug, Guinea Pigs, Hippocampus drug effects, Hippocampus physiology, Male, Microdialysis, Nucleus Accumbens drug effects, Nucleus Accumbens physiology, Peptide Fragments administration & dosage, Peptide Fragments pharmacology, Piperidines pharmacology, Prefrontal Cortex drug effects, Prefrontal Cortex physiology, Receptors, Neurokinin-3 agonists, Receptors, Neurokinin-3 antagonists & inhibitors, Substance P administration & dosage, Substance P analogs & derivatives, Substance P pharmacology, Substantia Nigra, Time Factors, Ventral Tegmental Area, Acetylcholine metabolism, Brain physiology, Dopamine metabolism, Receptors, Neurokinin-3 physiology, Synaptic Transmission
Abstract

The regulation of dopaminergic and cholinergic function by neurokinin-3 (NK3) receptor activation was examined in vivo in urethane-anaesthetized guinea pigs with microdialysis probes. The local application of the NK3 tachykinin receptor agonist senktide in the region of dopamine cell bodies (pars compacta of the substantia nigra and ventral tegmental area) and in the area of cholinergic cell bodies (septal area) markedly enhanced the extracellular dopamine (DA) and acetylcholine (ACh) concentration throughout their respective target areas, i.e. striatum, nucleus accumbens, prefrontal cortex for dopaminergic systems and hippocampus for cholinergic neurons. The enhancing effect of senktide on neurotransmitter release was dose dependently blocked by the selective non-peptide NK3 receptor antagonist SR142801 (0.1-1 mg/kg, i.p.), whereas its inactive S-enantiomer SR142806 (0.3-1 mg/kg, i.p.) did not exert any antagonistic activity on the effect of intranigral or intraseptal application of senktide. These results demonstrate that NK3 receptors can modulate the activity of central DA and ACh systems.

Published
1998
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4. Neurochemical and behavioural effects of neurotensin vs [D-Tyr11]neurotensin on mesolimbic dopaminergic function.

Author

Steinberg R, Brun P, Souilhac J, Bougault I, Leyris R, Le Fur G, and Soubrié P

Subjects
Animals, Behavior, Animal, Dose-Response Relationship, Drug, Male, Neurotensin analogs & derivatives, Neurotensin pharmacology, Nucleus Accumbens drug effects, Peptide Fragments pharmacology, Rats, Rats, Sprague-Dawley, Stereoisomerism, Ventral Tegmental Area drug effects, Dopamine metabolism, Nucleus Accumbens metabolism, Ventral Tegmental Area metabolism
Abstract

Microinjection of neurotensin(1-13) or neurotensin(8-13) into the ventral tegmental area (VTA) of anaesthetized rats produced dose-dependent (1-100 pg) dopamine release in the nucleus accumbens as measured by differential pulse amperometry (DPA). Higher doses (100 pg-10 ng) of [D-Tyr11]neurotensin were required to produce an identical effect. In addition, the 3 peptides enhanced the K(+)-evoked [3H]DA release from nucleus accumbens slices. The stimulatory actions produced by 10(-8) M neurotensin(1-13) and neurotensin(8-13) were respectively of 96% and 72% while the effect of [D-Tyr11]neurotensin was only of 79% at 10(-6) M. Unilateral application of the 3 peptides in the VTA of cannulated rats produced contralateral circling. [D-Tyr11]neurotensin was effective in a dose-dependent manner, between 40 and 320 ng. Similar effects were observed with 80 ng of neurotensin(1-13) and neurotensin(8-13) in presence of the protease inhibitor thiorphan. In view of the higher potency of neurotensin(1-13) and neurotensin(8-13) versus [D-Tyr11]neurotensin to stimulate DA release both in vivo and in vitro and the higher efficacy of [D-Tyr11]neurotensin to induce circling, this study further strengthens the concept of neurotensin receptor heterogeneity.

Published
1995
Full Text
View/download PDF

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