1. Astrocyte Intermediaries of Septal Cholinergic Modulation in the Hippocampus.
- Author
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Pabst M, Braganza O, Dannenberg H, Hu W, Pothmann L, Rosen J, Mody I, van Loo K, Deisseroth K, Becker AJ, Schoch S, and Beck H
- Subjects
- Animals, Astrocytes physiology, Hippocampus drug effects, Interneurons drug effects, Interneurons physiology, Learning physiology, Mice, Transgenic, Neural Pathways drug effects, Neurons drug effects, Neurons physiology, Septum of Brain cytology, Synaptic Transmission drug effects, Synaptic Transmission physiology, Astrocytes drug effects, Cholinergic Agents pharmacology, Hippocampus cytology, Neural Pathways physiology, Septum of Brain drug effects
- Abstract
The neurotransmitter acetylcholine, derived from the medial septum/diagonal band of Broca complex, has been accorded an important role in hippocampal learning and memory processes. However, the precise mechanisms whereby acetylcholine released from septohippocampal cholinergic neurons acts to modulate hippocampal microcircuits remain unknown. Here, we show that acetylcholine release from cholinergic septohippocampal projections causes a long-lasting GABAergic inhibition of hippocampal dentate granule cells in vivo and in vitro. This inhibition is caused by cholinergic activation of hilar astrocytes, which provide glutamatergic excitation of hilar inhibitory interneurons. These results demonstrate that acetylcholine release can cause slow inhibition of principal neuronal activity via astrocyte intermediaries., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
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