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6 results on '"Zhou, Zhuan"'

2. Differential Co-release of Two Neurotransmitters from a Vesicle Fusion Pore in Mammalian Adrenal Chromaffin Cells

Author

Zhang, Quanfeng, primary, Liu, Bin, additional, Wu, Qihui, additional, Liu, Bing, additional, Li, Yinglin, additional, Sun, Suhua, additional, Wang, Yuan, additional, Wu, Xi, additional, Chai, Zuying, additional, Jiang, Xiaohan, additional, Liu, Xiaoyao, additional, Hu, Meiqin, additional, Wang, Yeshi, additional, Yang, Yunting, additional, Wang, Li, additional, Kang, Xinjiang, additional, Xiong, Yingfei, additional, Zhou, Yang, additional, Chen, Xiaoke, additional, Zheng, Lianghong, additional, Zhang, Bo, additional, Wang, Changhe, additional, Zhu, Feipeng, additional, and Zhou, Zhuan, additional

Published
2019
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3. CaV2.2 Gates Calcium-Independent but Voltage-Dependent Secretion in Mammalian Sensory Neurons

Author

Chai, Zuying, primary, Wang, Changhe, additional, Huang, Rong, additional, Wang, Yuan, additional, Zhang, Xiaoyu, additional, Wu, Qihui, additional, Wang, Yeshi, additional, Wu, Xi, additional, Zheng, Lianghong, additional, Zhang, Chen, additional, Guo, Wei, additional, Xiong, Wei, additional, Ding, Jiuping, additional, Zhu, Feipeng, additional, and Zhou, Zhuan, additional

Published
2017
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5. Activation of Delta Opioid Receptors Induces Receptor Insertion and Neuropeptide Secretion

Author

Bao, Lan, primary, Jin, Shan-Xue, additional, Zhang, Chen, additional, Wang, Li-Hua, additional, Xu, Zhen-Zhong, additional, Zhang, Fang-Xiong, additional, Wang, Lie-Chen, additional, Ning, Feng-Shou, additional, Cai, Hai-Jiang, additional, Guan, Ji-Song, additional, Xiao, Hua-Sheng, additional, Xu, Zhi-Qing D., additional, He, Cheng, additional, Hökfelt, Tomas, additional, Zhou, Zhuan, additional, and Zhang, Xu, additional

Published
2003
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6. Ca V 2.2 Gates Calcium-Independent but Voltage-Dependent Secretion in Mammalian Sensory Neurons.

Author

Chai Z, Wang C, Huang R, Wang Y, Zhang X, Wu Q, Wang Y, Wu X, Zheng L, Zhang C, Guo W, Xiong W, Ding J, Zhu F, and Zhou Z

Subjects
Action Potentials drug effects, Animals, Caffeine pharmacology, Calcium Channel Blockers pharmacology, Cells, Cultured, Endoplasmic Reticulum drug effects, Endoplasmic Reticulum ultrastructure, Exocytosis drug effects, Exocytosis genetics, Ganglia, Spinal cytology, Ganglia, Spinal ultrastructure, Humans, Ion Channel Gating drug effects, Male, Membrane Fusion drug effects, Membrane Fusion genetics, Models, Molecular, Phosphodiesterase Inhibitors pharmacology, Presynaptic Terminals drug effects, Presynaptic Terminals physiology, Rats, Rats, Sprague-Dawley, Rats, Wistar, SNARE Proteins genetics, SNARE Proteins metabolism, Sensory Receptor Cells ultrastructure, Synaptic Transmission drug effects, Synaptic Transmission genetics, Transduction, Genetic, omega-Conotoxin GVIA pharmacology, Calcium metabolism, Calcium Channels, N-Type genetics, Calcium Channels, N-Type metabolism, Ion Channel Gating genetics, Sensory Receptor Cells physiology
Abstract

Action potential induces membrane depolarization and triggers intracellular free Ca 2+ concentration (Ca 2+ )-dependent secretion (CDS) via Ca 2+ influx through voltage-gated Ca 2+ channels. We report a new type of somatic exocytosis triggered by the action potential per se-Ca 2+ -independent but voltage-dependent secretion (CiVDS)-in dorsal root ganglion neurons. Here we uncovered the molecular mechanism of CiVDS, comprising a voltage sensor, fusion machinery, and their linker. Specifically, the voltage-gated N-type Ca 2+ channel (Ca V 2.2) is the voltage sensor triggering CiVDS, the SNARE complex functions as the vesicle fusion machinery, the "synprint" of Ca V 2.2 serves as a linker between the voltage sensor and the fusion machinery, and ATP is a cargo of CiVDS vesicles. Thus, CiVDS releases ATP from the soma while CDS releases glutamate from presynaptic terminals, establishing the Ca V 2.2-SNARE "voltage-gating fusion pore" as a novel pathway co-existing with the canonical "Ca 2+ -gating fusion pore" pathway for neurotransmitter release following action potentials in primary sensory neurons., (Copyright © 2017 Elsevier Inc. All rights reserved.)

Published
2017
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