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Your search keyword '"Zhu, Yicheng"' showing total 17 results
Start Over Author "Zhu, Yicheng" Journal neurology
17 results on '"Zhu, Yicheng"'

13. Plasma Lipids and Cerebral Small Vessel Disease (S40.002)

Author

Schilling, Sabrina, primary, Tzourio, Christophe, additional, Dufouil, Carole, additional, Zhu, Yicheng, additional, Berr, Claudine, additional, Alpérovitch, Annick, additional, Crivello, Fabrice, additional, Mazoyer, Bernard, additional, and Debette, Stéphanie, additional

Published
2014
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17. Plasma β-amyloid and MRI markers of cerebral small vessel disease: Three-City Dijon study.

Author

Kaffashian S, Tzourio C, Soumaré A, Dufouil C, Zhu Y, Crivello F, Maillard P, Schraen-Maschke S, Mazoyer B, Buée L, and Debette S

Subjects
Aged, Aged, 80 and over, Biomarkers blood, Cerebral Small Vessel Diseases epidemiology, Female, Follow-Up Studies, France epidemiology, Humans, Longitudinal Studies, Male, Amyloid beta-Peptides blood, Cerebral Small Vessel Diseases blood, Cerebral Small Vessel Diseases diagnosis, Magnetic Resonance Imaging trends, Peptide Fragments blood
Abstract

Objective: We investigated the relation of circulating plasma β-amyloid (Aβ) with MRI markers of small vessel disease (SVD) in dementia-free community persons., Methods: Participants were 1,690 individuals aged 65 to 80 years from the Three-City Dijon Study. Plasma Aβ measurement and MRI examination were performed at baseline and after a 4-year follow-up. MRI markers of SVD included white matter hyperintensities (WMH), lacunes, and enlarged perivascular spaces. We examined the relation of plasma Aβ levels with MRI markers of SVD at baseline and with progression of WMH over follow-up (n = 1,057). We also assessed whether these relations were modified by vascular risk factors, notably blood pressure., Results: Low plasma Aβ1-40 levels were associated with increased progression of WMH, and low Aβ1-42 with higher odds of extensive WMH progression over the follow-up (odds ratio = 1.66, 95% confidence interval = 1.16-2.38). Consistently low Aβ1-40 and Aβ1-42 levels on both measurements were associated with accelerated progression of WMH. These associations were modified by blood pressure levels but not the APOE ε4 genotype., Conclusions: Progression of WMH volume in dementia-free older persons is associated with levels of circulating plasma Aβ. These results reinforce the notion of an interrelation of vascular and neurodegenerative mechanisms in cerebral aging., (© 2014 American Academy of Neurology.)

Published
2014
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