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Your search keyword '"Sampaio, C."' showing total 9 results
Start Over Author "Sampaio, C." Journal neurology
9 results on '"Sampaio, C."'

1. Motor, cognitive, and functional declines contribute to a single progressive factor in early HD

Author

Schobel, S.A., Palermo, G., Auinger, P., Long, J.D., Ma, S.Y., Khwaja, O.S., Trundell, D., Cudkowicz, M., Hersch, S., Sampaio, C., Dorsey, E.R., Leavitt, B.R., Kieburtz, K.D., Sevigny, J.J., Langbehn, D.R., Tabrizi, S.J., TRACK-HD Huntington Study Grp, COHORT Huntington Study Grp, CARE-HD Huntington Study Grp, and 2CARE Huntington Study Grp

Subjects
0301 basic medicine, Adult, Male, medicine.medical_specialty, Ubiquinone, Apathy, Emotions, Disease, Neuropsychological Tests, Signal-To-Noise Ratio, Placebo group, Article, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Atrophy, Rating scale, medicine, Humans, Cognitive Dysfunction, Longitudinal Studies, Prospective Studies, Randomized Controlled Trials as Topic, business.industry, Reproducibility of Results, Cognition, Vitamins, Middle Aged, medicine.disease, Clinical trial, 030104 developmental biology, Huntington Disease, Social Perception, Motor Skills, Stroop Test, Disease Progression, Observational study, Female, Neurology (clinical), business, Facial Recognition, 030217 neurology & neurosurgery, Cohort study
Abstract

Objective:To identify an improved measure of clinical progression in early Huntington disease (HD) using data from prospective observational cohort studies and placebo group data from randomized double-blind clinical trials.Methods:We studied Unified Huntington Disease Rating Scale (UHDRS) and non-UHDRS clinical measures and brain measures of progressive atrophy in 1,668 individuals with early HD followed up prospectively for up to 30 to 36 months of longitudinal clinical follow-up.Results:The results demonstrated that a composite measure of motor, cognitive, and global functional decline best characterized clinical progression and was most strongly associated with brain measures of progressive corticostriatal atrophy.Conclusions:Use of a composite motor, cognitive, and global functional clinical outcome measure in HD provides an improved measure of clinical progression more related to measures of progressive brain atrophy and provides an opportunity for enhanced clinical trial efficiency relative to currently used individual motor, cognitive, and functional outcome measures.

Published
2017

2. Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes

Author

Bonifati V., Rohe C. F., Breedveld G. J., Fabrizio E., De Mari M., Tassorelli C., Tavella A., Marconi R., Nicholl D. J., Chien H. F., Fincati E., Abbruzzese G., Marini P., De Gaetano A., Horstink M. W., Maat Kievit J. A., Sampaio C., Antonini A., Stocchi F., Toni V., Guidi M., Dalla Libera A., Tinazzi M., De Pandis F., Fabbrini G., Goldwurm S., de Klein A., Barbosa E., Lopiano L., Martignoni E., Lamberti P., Vanacore N., Meco G., Oostra B.A., Italian Parkinson Genetics Network, MONTAGNA, PASQUALE, Bonifati V., Rohe C.F., Breedveld G.J., Fabrizio E., De Mari M., Tassorelli C., Tavella A., Marconi R., Nicholl D.J., Chien H.F., Fincati E., Abbruzzese G., Marini P., De Gaetano A., Horstink M.W., Maat-Kievit J.A., Sampaio C., Antonini A., Stocchi F., Montagna P., Toni V., Guidi M., Dalla Libera A., Tinazzi M., De Pandis F., Fabbrini G., Goldwurm S., de Klein A., Barbosa E., Lopiano L., Martignoni E., Lamberti P., Vanacore N., Meco G., Oostra BA., Italian Parkinson Genetics Network., and Clinical Genetics

Subjects
Adult, Male, DNA, Complementary, Adolescent, Genotype, Parkinson's disease, assessment, DNA Mutational Analysis, Mutation, Missense, Biology, Early-onset parkinsonism, medicine.disease_cause, Genotype-phenotype distinction, Cognitive neurosciences [UMCN 3.2], Gene Frequency, PINK1 gene mutations, medicine, Missense mutation, Humans, Genetic Predisposition to Disease, Genetic Testing, Allele, Age of Onset, Child, Allele frequency, Genetics, Mutation, Parkinson'disease, Genome, Polymorphism, Genetic, Sequence Homology, Amino Acid, Parkinsonism, Parkinson Disease, Middle Aged, medicine.disease, Phenotype, Italy, Female, Neurology (clinical), Age of onset, Protein Kinases
Abstract

Item does not contain fulltext OBJECTIVE: To assess the prevalence, nature, and associated phenotypes of PINK1 gene mutations in a large series of patients with early-onset (

Published
2005

4. Report of the task force on designing clinical trials in early (predementia) AD

Author

Aisen, P. S., primary, Andrieu, S., additional, Sampaio, C., additional, Carrillo, M., additional, Khachaturian, Z. S., additional, Dubois, B., additional, Feldman, H. H., additional, Petersen, R. C., additional, Siemers, E., additional, Doody, R. S., additional, Hendrix, S. B., additional, Grundman, M., additional, Schneider, L. S., additional, Schindler, R. J., additional, Salmon, E., additional, Potter, W. Z., additional, Thomas, R. G., additional, Salmon, D., additional, Donohue, M., additional, Bednar, M. M., additional, Touchon, J., additional, and Vellas, B., additional

Published
2010
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5. Hyposmia in G2019S LRRK2-related parkinsonism

Author

Silveira-Moriyama, L., primary, Guedes, L. C., additional, Kingsbury, A., additional, Ayling, H., additional, Shaw, K., additional, Barbosa, E. R., additional, Bonifati, V., additional, Quinn, N. P., additional, Abou-Sleiman, P., additional, Wood, N. W., additional, Petrie, A., additional, Sampaio, C., additional, Ferreira, J. J., additional, Holton, J., additional, Revesz, T., additional, and Lees, A. J., additional

Published
2008
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