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Your search keyword '"Psaty, B. M."' showing total 11 results
Start Over Author "Psaty, B. M." Journal neurology
11 results on '"Psaty, B. M."'

1. Separate prediction of intracerebral hemorrhage and ischemic stroke

Author

Ferket, B. S., primary, van Kempen, B. J. H., additional, Wieberdink, R. G., additional, Steyerberg, E. W., additional, Koudstaal, P. J., additional, Hofman, A., additional, Shahar, E., additional, Gottesman, R. F., additional, Rosamond, W., additional, Kizer, J. R., additional, Kronmal, R. A., additional, Psaty, B. M., additional, Longstreth, W. T., additional, Mosley, T., additional, Folsom, A. R., additional, Hunink, M. G. M., additional, and Ikram, M. A., additional

Published
2014
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3. No advantage of A 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies

Author

Szekely, C. A., primary, Green, R. C., additional, Breitner, J.C.S., additional, Ostbye, T., additional, Beiser, A. S., additional, Corrada, M. M., additional, Dodge, H. H., additional, Ganguli, M., additional, Kawas, C. H., additional, Kuller, L. H., additional, Psaty, B. M., additional, Resnick, S. M., additional, Wolf, P. A., additional, Zonderman, A. B., additional, Welsh-Bohmer, K. A., additional, and Zandi, P. P., additional

Published
2008
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11. No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies.

Author

Szekely CA, Green RC, Breitner JC, Østbye T, Beiser AS, Corrada MM, Dodge HH, Ganguli M, Kawas CH, Kuller LH, Psaty BM, Resnick SM, Wolf PA, Zonderman AB, Welsh-Bohmer KA, and Zandi PP

Subjects
Acetaminophen therapeutic use, Adolescent, Adult, Aged, Aged, 80 and over, Analgesics, Non-Narcotic therapeutic use, Aspirin therapeutic use, Cohort Studies, Female, Humans, Male, Middle Aged, Proportional Hazards Models, Prospective Studies, Risk Factors, Alzheimer Disease prevention & control, Amyloid beta-Peptides metabolism, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Neuroprotective Agents therapeutic use, Peptide Fragments metabolism
Abstract

Introduction: Observational studies show reduced incidence of Alzheimer dementia (AD) in users of nonsteroidal anti-inflammatory drugs (NSAIDs). One hypothesis holds that the subset of NSAIDs known as selective A beta(42)-lowering agents (SALAs) is responsible for this apparent reduction in AD risk., Methods: We pooled individual-level data from six prospective studies to obtain a sufficient sample to examine AD risk in users of SALA vs non-SALA NSAIDs., Results: Of 13,499 initially dementia-free participants (70,863 person-years), 820 developed incident AD. Users of NSAIDs (29.6%) showed reduced risk of AD (adjusted hazard ratio [aHR] 0.77, 95% CI 0.65-0.91). The point estimates were similar for SALAs (aHR 0.87, CI 0.72-1.04) and non-SALAs (aHR 0.75, CI 0.56-1.01). Because 573 NSAID users (14.5%) reported taking both a SALA and non-SALA, we examined their use alone and in combination. Resulting aHRs were 0.82 (CI 0.67-0.99) for SALA only, 0.60 (CI 0.40-0.90) for non-SALA only, and 0.87 (CI 0.57-1.33) for both NSAIDs (Wald test for differences, p = 0.32). The 40.7% of participants who used aspirin also showed reduced risk of AD, even when they used no other NSAIDs (aHR 0.78, CI 0.66-0.92). By contrast, there was no association with use of acetaminophen (aHR 0.93, CI 0.76-1.13)., Conclusions: In this pooled dataset, nonsteroidal anti-inflammatory drug (NSAID) use reduced the risk of Alzheimer dementia (AD). However, there was no apparent advantage in AD risk reduction for the subset of NSAIDs shown to selectively lower A beta(42), suggesting that all conventional NSAIDs including aspirin have a similar protective effect in humans.

Published
2008
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