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18 results on '"Massacesi, A"'

1. Long-Term Clinical Outcomes of Hematopoietic Stem Cell Transplantation in Multiple Sclerosis

Author

Boffa, Giacomo, Massacesi, Luca, Inglese, Matilde, Mariottini, Alice, Capobianco, Marco, Lucia, Moiola, Amato, Maria Pia, Cottone, Salvatore, Gualandi, Francesca, De Gobbi, Marco, Greco, Raffaella, Scimè, Rosanna, Frau, Jessica, Zimatore, Giovanni Bosco, Bertolotto, Antonio, Comi, Giancarlo, Uccelli, Antonio, Signori, Alessio, Angelucci, Emanuele, Innocenti, Chiara, Ciceri, Fabio, Repice, Anna Maria, Sormani, Maria Pia, Saccardi, Riccardo, and Mancardi, Gianluigi

Published
2021
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2. Long-term Clinical Outcomes of Hematopoietic Stem Cell Transplantation in Multiple Sclerosis

Author

Maria Pia Sormani, Marco Capobianco, Matilde Inglese, Emanuele Angelucci, Rosanna Scimè, Raffaella Greco, Salvatore Cottone, Giancarlo Comi, Antonio Bertolotto, Alessio Signori, Riccardo Saccardi, Luca Massacesi, Lucia Moiola, Jessica Frau, Antonio Uccelli, Marco De Gobbi, Anna Maria Repice, Maria Pia Amato, Fabio Ciceri, Alice Mariottini, G. B. Zimatore, Francesca Gualandi, Gianluigi Mancardi, Giacomo Boffa, Chiara Innocenti, Boffa, Giacomo, Massacesi, Luca, Inglese, Matilde, Mariottini, Alice, Capobianco, Marco, Lucia, Moiola, Amato, Maria Pia, Cottone, Salvatore, Gualandi, Francesca, De Gobbi, Marco, Greco, Raffaella, Scimè, Rosanna, Frau, Jessica, Zimatore, Giovanni Bosco, Bertolotto, Antonio, Comi, Giancarlo, Uccelli, Antonio, Signori, Alessio, Angelucci, Emanuele, Innocenti, Chiara, Ciceri, Fabio, Repice, Anna Maria, Sormani, Maria Pia, Saccardi, Riccardo, and Mancardi, Gianluigi

Subjects
Oncology, 0301 basic medicine, Melphalan, medicine.medical_specialty, Expanded Disability Status Scale, business.industry, Multiple sclerosis, medicine.medical_treatment, Hazard ratio, Hematopoietic stem cell transplantation, medicine.disease, Confidence interval, Term (time), Transplantation, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Internal medicine, Medicine, Neurology (clinical), business, 030217 neurology & neurosurgery, Etoposide, medicine.drug
Abstract

ObjectiveTo determine whether autologous hematopoietic stem cell transplantation (aHSCT) is able to induce durable disease remission in people with multiple sclerosis (MS), we analyzed the long-term outcomes after transplantation in a large cohort of patients with MS.MethodsTo be included, a minimum dataset (consisting of age, MS phenotype, Expanded Disability Status Scale [EDSS] score at baseline, information on transplantation technology, and at least 1 follow-up visit after transplantation) was required.ResultsTwo hundred ten patients were included (relapsing-remitting [RR] MS 122 [58%]). Median baseline EDSS score was 6 (1–9); mean follow-up was 6.2 (±5.0) years. Among patients with RRMS, disability worsening–free survival (95% confidence interval [CI]) was 85.5% (76.9%–94.1%) at 5 years and 71.3% (57.8%–84.8%) at 10 years. In patients with progressive MS, disability worsening–free survival was 71.0% (59.4%–82.6%) and 57.2% (41.8%–72.7%) at 5 and 10 years, respectively. In patients with RRMS, EDSS significantly reduced after aHSCT (p = 0.001; mean EDSS change per year −0.09 [95% CI −0.15% to −0.04%]). In patients with RRMS, the use of the BCNU+Etoposide+Ara-C+Melphalan (BEAM) + anti-thymocyte globulin (ATG) conditioning protocol was independently associated with a reduced risk of no evidence of disease activity 3 failure (hazard ratio 0.27 [95% CI 0.14–0.50], p < 0.001). Three patients died within 100 days from aHSCT (1.4%); no deaths occurred in patients transplanted after 2007.ConclusionsaHSCT prevents disability worsening in the majority of patients and induces durable improvement in disability in patients with RRMS. The BEAM + ATG conditioning protocol is associated with a more pronounced suppression of clinical relapses and MRI inflammatory activity.Classification of EvidenceThis study provides Class IV evidence that for people with MS, aHSCT induces durable disease remission in most patients.

Published
2021
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5. Hematopoietic Stem Cell Transplantation in People With Active Secondary Progressive Multiple Sclerosis.

Author

Boffa, Giacomo, Signori, Alessio, Massacesi, Luca, Mariottini, Alice, Sbragia, Elvira, Cottone, Salvatore, Amato, Maria Pia, Gasperini, Claudio, Moiola, Lucia, Meletti, Stefano, Repice, Anna Maria, Brescia Morra, Vincenzo, Salemi, Giuseppe, Patti, Francesco, Filippi, Massimo, De Luca, Giovanna, Lus, Giacomo, Zaffaroni, Mauro, Sola, Patrizia, and Conte, Antonella

Published
2023
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6. Baseline Patient and Caregiver Characteristics From a Prospective, Noninterventional, Real-World Study (REALITY) on the Effect of Alemtuzumab on Fatigue and Other Patient- and Caregiver-Reported Quality-of-Life Outcomes in Patients With RRMS (143)

Author

Eriksen, Stig, primary, van Exel, Job, additional, Frederiksen, Jette L., additional, Nielsen, Helle Hvilsted, additional, Torkildsen, Øivind, additional, Rini, Augusto, additional, Massacesi, Luca, additional, Mondino, Margaret, additional, Mirabella, Massimiliano, additional, Lugaresi, Alessandra, additional, Lus, Giacomo, additional, Paolicelli, Damiano, additional, Caniatti, Luisa Maria, additional, Tsai, Jon A., additional, and Scarpini, Elio, additional

Published
2020
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7. MS patients with low central vein sign frequency can be identified by FLAIR* MRi sequences (P5.2-041)

Author

Azzolini, Federica, primary, Grammatico, Matteo, additional, Carlucci, Giovanna, additional, Goanta, Lucia, additional, Dallagiacoma, Stefania, additional, Repice, Anna Maria Rita, additional, Forci, Benedetta, additional, Dipasquale, Francesca, additional, Marchi, Leonardo, additional, Fainardi, Enrico, additional, and Massacesi, Luca, additional

Published
2019
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12. Efficacy Analysis of the Anti-LINGO-1 Monoclonal Antibody BIIB033 in Acute Optic Neuritis: the RENEW Trial (P7.202)

Author

Cadavid, Diego, primary, Balcer, Laura, additional, Galetta, Steven, additional, Aktas, Orhan, additional, Ziemssen, Tjalf, additional, Vanopdenbosch, Ludo, additional, Butzkueven, Helmut, additional, Ziemssen, Focke, additional, Massacesi, Luca, additional, Chai, Yi, additional, Xu, Lei, additional, and Freeman, Stefanie, additional

Published
2015
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13. Early Cyclophosphamide Pulses Therapy is able to Reduce Disease Reactivation after Natalizumab Discontinuation: Preliminary Results from a Multicentric Database. (P3.292)

Author

Capobianco, Marco, primary, Lo Re, Marianna, additional, Sangalli, Francesca, additional, Moiola, Lucia, additional, Perini, Paola, additional, Gallo, Paolo, additional, Provinciali, Leandro, additional, Danni, Maura, additional, Repice, Anna, additional, Massacesi, Luca, additional, Patti, Francesco, additional, Messina, Silvia, additional, and Bertolotto, Antonio, additional

Published
2015
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17. Autologous hematopoietic stem cell transplantation in multiple sclerosis: A phase II trial.

Author

Mancardi, Giovanni L, Sormani, Maria P, Gualandi, Francesca, Saiz, Albert, Carreras, Eric, Merelli, Elisa, Donelli, Amedea, Lugaresi, Alessandra, Di Bartolomeo, Paolo, Rottoli, Maria R, Rambaldi, Alessandro, Amato, Maria P, Massacesi, Luca, Di Gioia, Massimo, Vuolo, Luisa, Currò, Daniela, Roccatagliata, Luca, Filippi, Massimo, Aguglia, Umberto, and Iacopino, Pasquale

Published
2015
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18. Autologous hematopoietic stem cell transplantation suppresses Gd-enhanced MRI activity in MS

Author

Mancardi, G. L., primary, Saccardi, R., additional, Filippi, M., additional, Gualandi, F., additional, Murialdo, A., additional, Inglese, M., additional, Marrosu, M. G., additional, Meucci, G., additional, Massacesi, L., additional, Lugaresi, A., additional, Pagliai, F., additional, Sormani, M. P., additional, Sardanelli, F., additional, and Marmont, A., additional

Published
2001
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