11 results on '"Laroni, Alice"'
Search Results
2. Pregnancy decision-making in women with multiple sclerosis treated with natalizumab: II: Maternal risks
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Portaccio, Emilio, Moiola, Lucia, Martinelli, Vittorio, Annovazzi, Pietro, Ghezzi, Angelo, Zaffaroni, Mauro, Lanzillo, Roberta, Brescia Morra, Vincenzo, Rinaldi, Francesca, Gallo, Paolo, Tortorella, Carla, Paolicelli, Damiano, Pozzilli, Carlo, De Giglio, Laura, Cavalla, Paola, Cocco, Eleonora, Marrosu, Maria Giovanna, Solaro, Claudio, Uccelli, Antonio, Laroni, Alice, Pastò, Luisa, Giannini, Marta, Trojano, Maria, Comi, Giancarlo, and Amato, Maria Pia
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- 2018
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3. Assessing association of comorbidities with treatment choice and persistence in MS: A real-life multicenter study
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Laroni, Alice, Signori, Alessio, Maniscalco, Giorgia T., Lanzillo, Roberta, Russo, Cinzia Valeria, Binello, Eleonora, Lo Fermo, Salvatore, Repice, Annamaria, Annovazzi, Pietro, Bonavita, Simona, Clerico, Marinella, Baroncini, Damiano, Prosperini, Luca, La Gioia, Sara, Rossi, Silvia, Cocco, Eleonora, Frau, Jessica, Torri Clerici, Valentina, Signoriello, Elisabetta, Sartori, Arianna, Zarbo, Ignazio Roberto, Rasia, Sarah, Cordioli, Cinzia, Cerqua, Raffaella, Di Sapio, Alessia, Lavorgna, Luigi, Pontecorvo, Simona, Barrilà, Caterina, Saccà, Francesco, Frigeni, Barbara, Esposito, Sabrina, Ippolito, Domenico, Gallo, Fabio, and Sormani, Maria Pia
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- 2017
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4. Ocrelizumab treatment in patients with progressive multiple sclerosis: a single-center real-world experience (2504)
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Cellerino, Maria, primary, Boffa, Giacomo, additional, Lapucci, Caterina, additional, Sbragia, Elvira, additional, Bruschi, Nicolo, additional, Mancuso, Elisabetta, additional, Tazza, Francesco, additional, Poire, Ilaria, additional, Laroni, Alice, additional, Capello, Elisabetta, additional, Uccelli, Antonio, additional, Novi, Giovanni, additional, and Inglese, Matilde, additional
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- 2021
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5. Autologous hematopoietic stem cell transplantation versus alemtuzumab in aggressive MS: a retrospective real-word study (4096)
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Lapucci, Caterina, primary, Boffa, Giacomo, additional, Sbragia, Elvira, additional, Capello, Elisabetta, additional, Currò, Daniela, additional, Laroni, Alice, additional, Roccatagliata, Luca, additional, Uccelli, Antonio, additional, Gualandi, Francesca, additional, Mancardi, Giovanni Luigi, additional, and Inglese, Matilde, additional
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- 2020
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6. Tailoring B-cells depleting therapy in MS according to memory B-cells monitoring: a pilot study (2159)
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Novi, Giovanni, primary, Fabbri, Sabrina, additional, Bovis, Francesca, additional, Sbragia, Elvira, additional, Gazzola, Paola, additional, Maietta, Ilaria, additional, Boffa, Giacomo, additional, Cellerino, Maria, additional, Lapucci, Caterina, additional, Bruschi, Nicolò, additional, Capello, Elisabetta, additional, Laroni, Alice, additional, Mancardi, Giovanni Luigi, additional, Sormani, Maria Pia, additional, Inglese, Matilde, additional, and Uccelli, Antonio, additional
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- 2020
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7. A Real-Life Study of Alemtuzumab: Impact of Previous Therapies and Washout Period on Disease Activity (P6.349)
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Sacca, Francesco, primary, Sormani, Maria Pia, additional, Signori, Alessio, additional, Lanzillo, Roberta, additional, Baroncini, Damiano, additional, Annovazzi, Pietro, additional, Signoriello, Elisabetta, additional, Laroni, Alice, additional, Capobianco, Marco, additional, Sartori, Arianna, additional, La Gioia, Sara, additional, Maniscalco, Giorgia Teresa, additional, Cordioli, Cinzia, additional, Rasia, Sarah, additional, Clerico, Marinella, additional, Fenu, Giuseppe, additional, Cocco, Eleonora, additional, and Frau, Jessica, additional
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- 2018
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8. Parenthood and Multiple Sclerosis: an explorative web-based study. (P4.365)
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Lavorgna, Luigi, primary, Esposito, Sabrina, additional, Lanzillo, Roberta, additional, Cocco, Eleonora, additional, Clerico, Marinella, additional, Fenu, Giuseppe, additional, Borriello, Giovanna, additional, De Mercanti, Stefania Federica, additional, Frau, Jessica, additional, Capuano, Rocco, additional, Rosa, Laura, additional, Laroni, Alice, additional, Morra, Vincenzo Brescia, additional, Tedeschi, Gioacchino, additional, and Bonavita, Simona, additional
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- 2018
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9. Autologous hematopoietic stem cell transplantation in multiple sclerosis
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Sormani, Maria Pia, primary, Muraro, Paolo A., additional, Schiavetti, Irene, additional, Signori, Alessio, additional, Laroni, Alice, additional, Saccardi, Riccardo, additional, and Mancardi, Gian Luigi, additional
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- 2017
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10. Switch Strategies in RRMS: A Real-Life Multi Center Study (S24.003)
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Sacc, Francesco, primary, Signori, Alessio, additional, Maniscalco, Giorgia Teresa, additional, Lanzillo, Roberta, additional, Lo Fermo, Salvatore, additional, Annovazzi, Pietro, additional, Prosperini, Luca, additional, Cocco, Eleonora, additional, Bonavita, Simona, additional, Torri Clerici, Valentina, additional, Laroni, Alice, additional, Repice, Anna Maria, additional, Zarbo, Ignazio Roberto, additional, Raffaella, Cerqua, additional, Di Sapio, Alessia, additional, Pontecorvo, Simona, additional, Clerico, Marinella, additional, Lavorgna, Luigi, additional, Barrillà, Caterina, additional, Cordioli, Cinzia, additional, Gallo, Fabio, additional, and Sormani, Maria Pia, additional
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- 2016
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11. The incidence and significance of anti-natalizumab antibodies: results from AFFIRM and SENTINEL
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Calabresi, Pa, Giovannoni, G, Confavreux, C, Galetta, Sl, Havrdova, E, Hutchinson, M, Kappos, L, Miller, Dh, O'Connor, Pw, Phillips, Jt, Polman, Ch, Radue, Ew, Rudick, Ra, Stuart, Wh, Lublin, Fd, Wajgt, A, Weinstock Guttman, B, Wynn, Dr, Lynn, F, Panzara, Ma, Affirm, Investigators, Fazekas, SENTINEL Investigators including: F., Enzinger, C., Seifert, T., Storch, M., Strasser Fuchs, S., Berger, T., Dilitz, E., Egg, R., Eisenhammer, F., Decoo J. Lampaert, D. Decoo J. Lampaert, Bartholome J. Bier, E. Bartholome J. Bier, Stenager, E., Rasmussen, M., Binzer, M., Shorsh, K., Christensen, M., Ravnborg, M., Soelberg Sørensen, P., Blinkenberg, M., Petersen, B., Hansen, H. J., Bech, E., Petersen, T., Kirkegaard, M., Eralinna, J., Ruutiainen, J., Soilu Hänninen, M., Säkö, E., Laaksonen, M., Reunanen, M., Remes, A., Keskinarkaus, I., Moreau, T., Noblet, M., Rouaud, O., Couvreur, G., Edan, G., Lepage, E., Drapier, S., De Burghgraeve, V., Yaouanq, J., Merienne, M., Cahagne, V., Gout, O., Deschamps, R., Le Canuet, P., Moulignier, A., Vermersch, P., De Seze, J., Stojkovic, T., Griffié, G., Engles, A., Ferriby, D., Debouverie, M., Pittionvouyouvitch, S., Lacour, J. C., Pelletier, J., Feuillet, L., Suchet, L., Dalecky, A., Tammam, D., Lubetzki, C., Youssov, K., Mrejen, S., Charles, P., Yaici, S., Clavelou, P., Aufauvre, D., Renouil Guy, N., Cesaro, P., Degos, F., Benisty, S., Rumbach P. Decavel, L. Rumbach P. Decavel, Confavreux, C., Blanc, S., Aubertin, P., Riche, G., Brochet, B., Ouallet, J. C., Anne, O., Menck, S., Grupe, A., Guttman, E., Lensch, E., Fucik, E., Heitmann, S., Hartung, H. P., Schröter, M., Kurz, F. M. W., Heidenreich, F., Trebst, C., Pul, R., Hohlfeld, R., Krumbholz, M., Pellkofer, H., Haas, J., Segert, A., Meyer, R., Anagnostou, P., Kabus, C., Poehlau, D., Schneider, K., Hoffmann, V., Zettl, U., Steinhagen, V., Adler, S., Steinbrecher, A., Rothenfusser Körber, E., Zellner, R., Baum, K., Günther, A., Bläsing, H., Stoll, G., Gold, R., Bayas, A., Kleinschnitz, C., Limmroth, V., Katsarava, Z., Kastrup, O., Haller, P., Stoeve, S., Höbel, D., Oschmann, P., Voigt, K., Burger, C. V., Abramsky D. Karusiss, O. Abramsky D. Karusiss, Achiron, A., Kishner, I., Stern, Y., Sarove Pinhas, I., Dolev, M., Magalashvili, D., Pozzili, C., Lenzi, D., Scontrini, A., Millefiorini, E., Buttinelli, C., Gallo, P., Ranzato, F., Tiberio, M., Perini, P., Laroni, Alice, Marrosu, M., Cocco P. Marchi, E. Cocco P. Marchi, Spinicci, G., Massole, S., Mascia, M., Floris, G., Trojano, M., Bellacosa, A., Paolicelli, D., Bosco Zimatore, G., Simone, I. L., Giorelli, M., Di Monte, E., Mancardi, GIOVANNI LUIGI, Pizzorno, M., Murialdo, A., Narciso, E., Capello, A., Comi, G., Martinelli, V., Rodegher, M., Esposito, F., Colombo, B., Rossi, P., Polman, C. H., Jasperse, M. M. S., Zwemmer, J. N. P., Nielsen, J., Kragt, J. J., Jongen, P. J. H., De Smet, E., Tacken, H., Frequin, S. T. F. M., Siegers, H. P., Mauser, H. W., Fern ez Fern ez, O., León, A., Romero, F., Alonso, A., Tamayo, J., Montalban, X., Nos, C., Pelayo, R., Tellez, N., Rio, J., Tintore, M., Arbizu, T., Romero, L., Moral, E., Martinez, S., Kappos, L., Achtnichts, L., Wilmes, S., Karabudak, R., Kurne, A., Erdem, S., Siva, A., Saip, S., Altintas, A., Atamer, A., Eraksoy, M., Bilgili, F., Topcular, B., Giovannoni ET Lim, G. Giovannoni E. T. Lim, Lava, N., Murnane, M., Dentinger, M., Zimmerman, E., Reiss V. Gupta, M. Reiss V. Gupta, Scott, T., Brillman, J., Kunschner, L., Wright, D., Perel A. Babu, A. Perel A. Babu, Rivera, V., Killian, J., Hutton, G., Lai, E., Picone, M., Cadivid, D., Kamin, S., Shanawani, M., Gauthier, S., Morgan, A., Buckle, G., Margolin, D., Weinstock Guttman, B., Kwen, P. L., Garg, N., Munschauer, F., Khatri, B., Rassouli, M., Saxena, V., Ahmed, A., Turner, A., Fox, E., Couch, C., Tyler, R., Horvit, A., Fodor S. Humphries, P. Fodor S. Humphries, Wynn, D., Nagar, C., O’Brien, D., Allen, N., Turel, A., Friedenberg, S., Carlson, J., Hosey, J., Crayton, H., Richert, J., Tornatore, C., Sirdofsky, M., Greenstein, J., Shpigel, Y., S. M, El, Adbelhak, T., Schmerler, M., Zadikoff, C., Rorick, M., Reed, R., Elias, S., Feit, H., Angus, E., Sripathi, N., Herbert, J., Kiprovski, K., Qu, X., Del Bene, M., Mattson, D., Hingtgen, C., Fleck, J., Horak, H., Kaiser, J. Javerbaum, Elmore, R., Garcia, E., Tasch, E., Gruener, G., Celesia, G., Chawla, J., Miller, A., Drexler, E., Keilson, M., Wolintz, R., Drasby, E., Muscat, P., Belden, J., Sullivan, R., Cohen, J., Stone, L., Marrie, R. A., Fox, R., Hughes, B., Babikian, P., Jacoby, M., Doro, J., Puricelli, M., Rossman, H., Boudoris, W., Belkin, M., Pierce, R., Eggenberger, E., Birbeck, G., Martin, J., Kaufman, D., Stuart, W., English, J. B., Stuart, D. S., Gilbert, R. W., Kaufman, M., Putman, S., Diedrich, A., Follmer, R., Pelletier, D., Waubant, E., Cree, B., Genain, C., Goodin, D., Guarnaccia, J., Patwa, H., Rizo, M., Kitaj, M., Blevins, J., Smith, T., Mcgee, F., Honeycutt, W., Brown, M., Isa, A., Nieves Quinones, D., Krupp, L., Smiroldo, J., Zarif, M., Perkins, C., Sumner, A., Fisher, A., Gutierrez, A., Jacoby, R., Svoboda, S., Dorn, D., Groeschel, A., Steingo R. Kishner, B. Steingo R. Kishner, Cohen, B., Melen, O., Simuni, T., Zee, P., Cohan M. Yerby, S. Cohan M. Yerby, Hendin, B., Levine, T., Tamm, H., Travis, L. H., Freedman, S. M., Tim, R., Ferrell, W., Stefoski, D., Stevens, S., Katsamakis, G., Topel, J., KoD Gelber C. Fortin, M. K. o. D. Gelber C. Fortin, Green, B., Logan, W., Carpenter, D., Temple, L., Sadiq, S., Sylvester, A., Sim, G., Mihai, C., Vertino, M., Jubelt, B., Mejico, L., Phillips, J. T., Martin, A., Heitzman, D., Greenfield, C. F., Riskind, P., Cabo, A., Paskavitz, J., Moonis, M., Bashir, K., Brockington, J., Nicholas, A., Slaughter, R., Archer, R., Harik, S., Haddad, N., Pippenger, M. A., Van den Noort, S., Thai, G., Olek, M., Demetriou, M., Shin, R., Calabresi, P., Rus, H., Bever, C., Johnson, K., Sheremata, W., Delgado, S., Sherbert, R., Herndon, R., Uschmann, H., Ch ler, A., Markowitz, C., Jacobs, D., Balcer, L., Mitchell, G., Chakravorty, S., Heyman, R., Stauber, Z., Goodman, A., Segal, B., Schwid, S., Samkoff, L., Levin, M., Jacewicz, M., Menkes, D., Pulsinelli, W., Frohman, E., Racke, M., Hawker, K., Ulrich, R., Panitch, H., Hamill, R., R. T, On, Dulaney, E., Simnad, V., Miller, J., Wooten, G. F., Harrison, M., Bowen, J., Doherty, M., Wundes, A., Garden, G. A., Distad, J., Kachuck, N., Berkovich, R., Burnett, M., Sahai, S., Ari, D. B, Weiner, L., Storey, J. R., Beesley, B., Hart, D., Moses, H., Sriram, S., Fang, J., O’Duffy, A., Kita, M., Taylor, L., Elliott, M., Roberts, J., Jeffery, D., Maxwell, S., Lefkowitz, D., Kumar, S., Sinclair EW Radue, M. S. i. n. c. l. a. i. r. E. W. Radue, de Vera, A., Bacelar, O., Kuster, P., and Kappos, L. .
- Subjects
medicine.medical_specialty ,Multiple Sclerosis ,Enzyme-Linked Immunosorbent Assay ,Relapsing-Remitting ,Antibodies, Monoclonal, Humanized ,Gastroenterology ,Antibodies ,law.invention ,Disability Evaluation ,Natalizumab ,Multiple Sclerosis, Relapsing-Remitting ,Randomized controlled trial ,Double-Blind Method ,law ,Antibody Specificity ,Internal medicine ,Monoclonal ,medicine ,Secondary Prevention ,Humans ,Adverse effect ,Antibodies, Blocking ,Humanized ,Antibodies, Monoclonal ,Brain ,Flow Cytometry ,Interferon-beta ,Magnetic Resonance Imaging ,Placebo Effect ,Treatment Outcome ,Neuroscience (all) ,Expanded Disability Status Scale ,business.industry ,Multiple sclerosis ,Incidence (epidemiology) ,Interferon beta-1a ,medicine.disease ,Blocking ,Multiple sclerosis functional composite ,Immunology ,Neurology (clinical) ,business ,medicine.drug - Abstract
Objective: To determine the incidence and clinical effects of antibodies that develop during treatment with natalizumab. Methods: In two randomized, double-blind, placebo-controlled studies (natalizumab safety and efficacy in relapsing remitting multiple sclerosis [MS, AFFIRM] and safety and efficacy of natalizumab in combination with interferon β-1a [INFβ1a] in patients with relapsing remitting MS [SENTINEL]) of patients with relapsing multiple sclerosis, blood samples were obtained at baseline and every 12 weeks to determine the presence of antibodies against natalizumab. Antibodies to natalizumab were measured using an ELISA. Patients were categorized as “transiently positive” if they had detectable antibodies (≥0.5 μg/mL) at a single time point or “persistently positive” if they had antibodies at two or more time points ≥6 weeks apart. Results: In the AFFIRM study, antibodies were detected in 57 of 625 (9%) of natalizumab-treated patients: Twenty (3%) were transiently positive and 37 (6%) were persistently positive. Persistently positive patients showed a loss of clinical efficacy as measured by disability progression ( p ≤ 0.05), relapse rate ( p = 0.009), and MRI ( p ≤ 0.05) compared with antibody-negative patients. In transiently positive patients, full efficacy was achieved after approximately 6 months of treatment, the time when patients were becoming antibody negative. The incidence of infusion-related adverse events was significantly higher in persistently positive patients. Results of SENTINEL were similar to AFFIRM, except with regard to sustained disability progression; differences between persistently positive and antibody-negative patients were not statistically significant. Conclusions: The incidence of persistent antibody positivity associated with natalizumab is 6%. Reduced clinical efficacy is apparent in persistently positive patients. Patients with a suboptimal clinical response or persistent infusion-related adverse events should be considered for antibody testing. GLOSSARY: BLQ = below the limit of quantification; EDSS = Expanded Disability Status Scale; Gd+ = gadolinium enhancing; IFNβ1a = interferon β-1a; MS = multiple sclerosis; MSFC = multiple sclerosis functional composite; OD = optical density.
- Published
- 2007
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