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Start Over Author "CAPUS L" Journal neurological sciences official journal of the italian neurological society and of the italian society of clinical neurophysiology
3 results on '"CAPUS L"'

1. Acute Akinesia, an unusual complication in Parkinson's Disease: a case report.

Author

Simonetto M, Ferigo L, Zanet L, Capus L, Antonutti L, Zorzon M, and Pizzolato G

Subjects
Acute Disease, Aged, Antiparkinson Agents metabolism, Apomorphine administration & dosage, Basal Ganglia Diseases diagnosis, Basal Ganglia Diseases drug therapy, Creatine Kinase blood, Disease Progression, Dopamine Agonists administration & dosage, Fever chemically induced, Fever metabolism, Fever physiopathology, Humans, Male, Ondansetron administration & dosage, Respiratory Insufficiency, Serotonin Antagonists administration & dosage, Syndrome, Treatment Outcome, Antiparkinson Agents adverse effects, Basal Ganglia Diseases physiopathology, Drug Resistance, Parkinson Disease complications
Abstract

Acute akinesia (AA) is a rare but serious complication of Parkinson's Disease (PD) 0,3% of all patients with PD). It can be related to infectious condition, surgery, or treatment changes. AA can completely recover or result in some motor deficits, and, in the most severe forms, it may lead to untreatable complications and death. Here we report the case of a 67-year-old man with PD who rapidly developed a severe akinetic state with rise of temperature (39 degrees C) and creatine phosphokinase concentration (up to 5000 mg/dL). After excluding infection diseases and other pathologies, we suspected AA and added apomorphine 50mg/die s.c. and ondansetron 8 mg i.v. The patient responded to treatment and ameliorated in few weeks.

Published
2008
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2. The parkin gene and its phenotype. Italian PD Genetics Study Group, French PD Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease.

Author

Bonifati V, De Michele G, Lücking CB, Dürr A, Fabrizio E, Ambrosio G, Vanacore N, De Mari M, Marconi R, Capus L, Breteler MM, Gasser T, Oostra B, Wood N, Agid Y, Filla A, Meco G, and Brice A

Subjects
Age of Onset, Antiparkinson Agents therapeutic use, Brain pathology, Brain physiopathology, Chromosome Mapping, DNA Mutational Analysis, Exons genetics, Genetic Testing, Humans, Ligases metabolism, Parkinsonian Disorders pathology, Parkinsonian Disorders physiopathology, Phenotype, Chromosomes, Human, Pair 6 genetics, Ligases genetics, Parkinsonian Disorders genetics, Point Mutation genetics, Ubiquitin-Protein Ligases
Abstract

Mutations of the parkin gene on chromosome 6 cause autosomal recessive, early onset parkinsonism. This is the most frequent form of monogenic parkinsonism so far identified. The associated phenotypical spectrum encompasses early onset, levodopa-responsive parkinsonism (average onset in the early 30s in Europe), and it overlaps with dopa-responsive dystonia in cases with the earliest onset, and with clinically typical Parkinson's disease in cases with later onset. Despite clinical features, Lewy bodies are not found at autopsy in brains of patients with parkin mutations. The parkin protein possesses ubiquitin ligase activity, which is abolished by the pathogenic mutations.

Published
2001
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3. Chronic bilateral electrical stimulation of the subthalamic nucleus for the treatment of advanced Parkinson's disease.

Author

Capus L, Melatini A, Zorzon M, Torre P, Carraro N, Moretti D, Gioulis M, Moretti R, Sarra MV, and Marsala SZ

Subjects
Aged, Antiparkinson Agents therapeutic use, Cognition Disorders pathology, Cognition Disorders physiopathology, Cognition Disorders surgery, Electric Stimulation Therapy adverse effects, Electric Stimulation Therapy instrumentation, Electrodes, Implanted adverse effects, Female, Functional Laterality physiology, Humans, Male, Middle Aged, Neuropsychological Tests, Neurosurgical Procedures adverse effects, Neurosurgical Procedures instrumentation, Parkinson Disease pathology, Parkinson Disease physiopathology, Quality of Life, Recovery of Function physiology, Subthalamic Nucleus pathology, Subthalamic Nucleus physiopathology, Treatment Outcome, Electric Stimulation Therapy methods, Electrodes, Implanted standards, Neurosurgical Procedures methods, Parkinson Disease surgery, Subthalamic Nucleus surgery
Abstract

Preliminary reports in patients with Parkinson's disease (PD) showed that subthalamic nucleus (STN) stimulation was able to reverse parkinsonian state. Since 1998 we evaluated the safety and the efficacy of STN stimulation in 7 patients affected by advanced PD. All patients were included using CAPIT protocol. Motor functions and quality of life were evaluated, before and after surgery, with UPDRS and PDQ38, respectively. At the 6-month follow-up, the off medication/on stimulation UPDRS motor score improved by 50.6% and the on medication/on stimulation by 20.3%. Motor fluctuations were reduced by 57.2% and dyskinesias by 73.5%. The total L-dopa equivalent daily dose was reduced by 40.7%. PDQ38 ameliorated by 49.9%. We did not observe any perioperatory complication and only mild and tolerable side effects after stimulation.

Published
2001
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