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This article discusses a case study of a 50-year-old patient who developed symptoms of vitamin B12-responsive methylmalonic acidemia (MMA), a metabolic disorder, at an unusually advanced age. The patient experienced seizures, status epilepticus, leukoencephalopathy, and myelopathy. The article emphasizes the importance of considering inborn metabolic disorders as potential causes of neurological symptoms in adults, even if they present at an older age. The authors recommend conducting biochemical screening investigations and genetic testing to accurately diagnose these conditions. [Extracted from the article]

Transient suppression of the motor cortex and of the speech areas cause well-described postictal phenomena following seizures involving the respective cortical areas. Pain is a rare symptom in epileptic seizures. We present a patient with painful tonic seizures in the left leg. The amplitude of the cortical component of the somatosensory evoked potential following stimulation of the left tibial nerve was reduced immediately after the seizure. Our findings suggest that the excitability of the sensory cortex is transiently reduced following a seizure involving the somatosensory area. [ABSTRACT FROM AUTHOR]