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Your search keyword '"Roido, Manavaki"' showing total 3 results
Start Over Author "Roido, Manavaki" Journal neuroimage
3 results on '"Roido, Manavaki"'

1. Validation of a combined image derived input function and venous sampling approach for the quantification of [18F]GE-179 PET binding in the brain

Author

Marian Galovic, Kjell Erlandsson, Tim D. Fryer, Young T. Hong, Roido Manavaki, Hasan Sari, Sarah Chetcuti, Benjamin A. Thomas, Martin Fisher, Selena Sephton, Roberto Canales, Joseph J Russell, Kerstin Sander, Erik Årstad, Franklin I. Aigbirhio, Ashley M. Groves, John S. Duncan, Kris Thielemans, Brian F. Hutton, Jonathan P. Coles, and Matthias J. Koepp

Subjects
Positron emission tomography, Input function, NMDA receptor, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Blood-based kinetic analysis of PET data relies on an accurate estimate of the arterial plasma input function (PIF). An alternative to invasive measurements from arterial sampling is an image-derived input function (IDIF). However, an IDIF provides the whole blood radioactivity concentration, rather than the required free tracer radioactivity concentration in plasma. To estimate the tracer PIF, we corrected an IDIF from the carotid artery with estimates of plasma parent fraction (PF) and plasma-to-whole blood (PWB) ratio obtained from five venous samples. We compared the combined IDIF+venous approach to gold standard data from arterial sampling in 10 healthy volunteers undergoing [18F]GE-179 brain PET imaging of the NMDA receptor. Arterial and venous PF and PWB ratio estimates determined from 7 patients with traumatic brain injury (TBI) were also compared to assess the potential effect of medication. There was high agreement between areas under the curves of the estimates of PF (r = 0.99, p

Published
2021
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2. Validation of a combined image derived input function and venous sampling approach for the quantification of [18F]GE-179 PET binding in the brain

Author

Kerstin Sander, Martin Fisher, Tim D. Fryer, Jonathan P. Coles, Joseph J. Russell, Erik Årstad, Benjamin A. Thomas, John S. Duncan, Ashley M. Groves, Kris Thielemans, Roberto Canales, Kjell Erlandsson, Hasan Sari, Marian Galovic, Franklin I. Aigbirhio, Young T. Hong, Roido Manavaki, Selena Milicevic Sephton, Nest investigators, Matthias J. Koepp, Sarah Chetcuti, Brian Hutton, Manavaki, Roido [0000-0002-4384-6626], Aigbirhio, Franklin [0000-0001-9453-5257], Coles, Jonathan [0000-0003-4013-679X], and Apollo - University of Cambridge Repository

Subjects
Adult, Male, Positron emission tomography, Cognitive Neuroscience, Kinetic analysis, Neuroimaging, Neurosciences. Biological psychiatry. Neuropsychiatry, Receptors, N-Methyl-D-Aspartate, 050105 experimental psychology, Veins, 03 medical and health sciences, 0302 clinical medicine, Venous sampling, Brain Injuries, Traumatic, Medicine, Humans, 0501 psychology and cognitive sciences, Whole blood, medicine.diagnostic_test, business.industry, Arterial plasma, 05 social sciences, Input function, Reproducibility of Results, Gold standard (test), Pet imaging, Middle Aged, NMDA receptor, Neurology, Positron-Emission Tomography, Female, Radiopharmaceuticals, business, Nuclear medicine, 030217 neurology & neurosurgery, RC321-571
Abstract

Blood-based kinetic analysis of PET data relies on an accurate estimate of the arterial plasma input function (PIF). An alternative to invasive measurements from arterial sampling is an image-derived input function (IDIF). However, an IDIF provides the whole blood radioactivity concentration, rather than the required free tracer radioactivity concentration in plasma. To estimate the tracer PIF, we corrected an IDIF from the carotid artery with estimates of plasma parent fraction (PF) and plasma-to-whole blood (PWB) ratio obtained from five venous samples. We compared the combined IDIF+venous approach to gold standard data from arterial sampling in 10 healthy volunteers undergoing [18F]GE-179 brain PET imaging of the NMDA receptor. Arterial and venous PF and PWB ratio estimates determined from 7 patients with traumatic brain injury (TBI) were also compared to assess the potential effect of medication. There was high agreement between areas under the curves of the estimates of PF (r = 0.99, p

Published
2021

3. Validation of a combined image derived input function and venous sampling approach for the quantification of [

Author

Marian, Galovic, Kjell, Erlandsson, Tim D, Fryer, Young T, Hong, Roido, Manavaki, Hasan, Sari, Sarah, Chetcuti, Benjamin A, Thomas, Martin, Fisher, Selena, Sephton, Roberto, Canales, Joseph J, Russell, Kerstin, Sander, Erik, Årstad, Franklin I, Aigbirhio, Ashley M, Groves, John S, Duncan, Kris, Thielemans, Brian F, Hutton, Jonathan P, Coles, and Matthias J, Koepp

Subjects
Adult, Male, Positron-Emission Tomography, Brain Injuries, Traumatic, Humans, Reproducibility of Results, Female, Neuroimaging, Middle Aged, Radiopharmaceuticals, Receptors, N-Methyl-D-Aspartate, Veins
Abstract

Blood-based kinetic analysis of PET data relies on an accurate estimate of the arterial plasma input function (PIF). An alternative to invasive measurements from arterial sampling is an image-derived input function (IDIF). However, an IDIF provides the whole blood radioactivity concentration, rather than the required free tracer radioactivity concentration in plasma. To estimate the tracer PIF, we corrected an IDIF from the carotid artery with estimates of plasma parent fraction (PF) and plasma-to-whole blood (PWB) ratio obtained from five venous samples. We compared the combined IDIF+venous approach to gold standard data from arterial sampling in 10 healthy volunteers undergoing [

Published
2020

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