1. The Center for Integrated Molecular Brain Imaging (Cimbi) database
- Author
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Knudsen, Gitte M, Jensen, Peter S, Erritzoe, David, Baaré, William FC, Ettrup, Anders, Fisher, Patrick M, Gillings, Nic, Hansen, Hanne D, Hansen, Lars Kai, Hasselbalch, Steen G, Henningsson, Susanne, Herth, Matthias M, Holst, Klaus K, Iversen, Pernille, Kessing, Lars V, Macoveanu, Julian, Madsen, Kathrine Skak, Mortensen, Erik L, Nielsen, Finn Årup, Paulson, Olaf B, Siebner, Hartwig R, Stenbæk, Dea S, Svarer, Claus, Jernigan, Terry L, Strother, Stephen C, and Frokjaer, Vibe G
- Subjects
Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Clinical Research ,Depression ,Neurosciences ,Brain Disorders ,Mental Health ,Biomedical Imaging ,Neurological ,Mental health ,Good Health and Well Being ,Biological Specimen Banks ,Biomarkers ,Computer Security ,Databases ,Factual ,Healthy Volunteers ,Humans ,Information Dissemination ,Magnetic Resonance Imaging ,Mental Disorders ,Molecular Imaging ,Neuroimaging ,Neuropsychological Tests ,Quality Control ,Receptors ,Serotonin ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery ,Biomedical and clinical sciences ,Health sciences - Abstract
We here describe a multimodality neuroimaging containing data from healthy volunteers and patients, acquired within the Lundbeck Foundation Center for Integrated Molecular Brain Imaging (Cimbi) in Copenhagen, Denmark. The data is of particular relevance for neurobiological research questions related to the serotonergic transmitter system with its normative data on the serotonergic subtype receptors 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4 and the 5-HT transporter (5-HTT), but can easily serve other purposes. The Cimbi database and Cimbi biobank were formally established in 2008 with the purpose to store the wealth of Cimbi-acquired data in a highly structured and standardized manner in accordance with the regulations issued by the Danish Data Protection Agency as well as to provide a quality-controlled resource for future hypothesis-generating and hypothesis-driven studies. The Cimbi database currently comprises a total of 1100 PET and 1000 structural and functional MRI scans and it holds a multitude of additional data, such as genetic and biochemical data, and scores from 17 self-reported questionnaires and from 11 neuropsychological paper/computer tests. The database associated Cimbi biobank currently contains blood and in some instances saliva samples from about 500 healthy volunteers and 300 patients with e.g., major depression, dementia, substance abuse, obesity, and impulsive aggression. Data continue to be added to the Cimbi database and biobank.
- Published
- 2016