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1. Longitudinal alteration of cortical thickness and volume in high-impact sports

Author

Brian D. Mills, Maged Goubran, Sherveen N. Parivash, Emily L. Dennis, Paymon Rezaii, Carolyn Akers, Wei Bian, Lex A. Mitchell, Brian Boldt, David Douglas, Sohrab Sami, Nicole Mouchawar, Eugene W. Wilson, Phil DiGiacomo, Mansi Parekh, Huy Do, Jaime Lopez, Jarrett Rosenberg, David Camarillo, Gerald Grant, Max Wintermark, and Michael Zeineh

Subjects
Structural brain development, High-impact sports, College football, Cortical thickness and volume, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Collegiate football athletes are subject to repeated head impacts. The purpose of this study was to determine whether this exposure can lead to changes in brain structure. This prospective cohort study was conducted with up to 4 years of follow-up on 63 football (high-impact) and 34 volleyball (control) male collegiate athletes with a total of 315 MRI scans (after exclusions: football n ​= ​50, volleyball n ​= ​24, total scans ​= ​273) using high-resolution structural imaging. Volumetric and cortical thickness estimates were derived using FreeSurfer 5.3’s longitudinal pipeline. A linear mixed-effects model assessed the effect of group (football vs. volleyball), time from baseline MRI, and the interaction between group and time. We confirmed an expected developmental decrement in cortical thickness and volume in our cohort (p ​

Published
2020
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2. Longitudinal alteration of cortical thickness and volume in high-impact sports

Author

Michael Zeineh, Lex A. Mitchell, Phil DiGiacomo, Gerald A. Grant, Paymon Rezaii, Nicole Mouchawar, Carolyn Akers, Jarrett Rosenberg, Emily L. Dennis, David B. Camarillo, Brian Boldt, Huy M. Do, Sohrab Sami, Wei Bian, Brian D. Mills, Jaime R. Lopez, David B. Douglas, Max Wintermark, Mansi B. Parekh, Sherveen N. Parivash, Eugene Wilson, and Maged Goubran

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Injury control, Cortical thickness and volume, Cognitive Neuroscience, Football, Poison control, Structural brain development, Functional Laterality, 050105 experimental psychology, lcsh:RC321-571, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Humans, Medicine, 0501 psychology and cognitive sciences, College football, Longitudinal Studies, Prospective Studies, Gray Matter, Prospective cohort study, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Brain Concussion, Cerebral Cortex, biology, business.industry, Athletes, 05 social sciences, Brain, biology.organism_classification, Magnetic Resonance Imaging, Volleyball, Neurology, High-impact sports, Cohort, business, Structural imaging, 030217 neurology & neurosurgery
Abstract

Collegiate football athletes are subject to repeated head impacts. The purpose of this study was to determine whether this exposure can lead to changes in brain structure. This prospective cohort study was conducted with up to 4 years of follow-up on 63 football (high-impact) and 34 volleyball (control) male collegiate athletes with a total of 315 MRI scans (after exclusions: football n ​= ​50, volleyball n ​= ​24, total scans ​= ​273) using high-resolution structural imaging. Volumetric and cortical thickness estimates were derived using FreeSurfer 5.3’s longitudinal pipeline. A linear mixed-effects model assessed the effect of group (football vs. volleyball), time from baseline MRI, and the interaction between group and time. We confirmed an expected developmental decrement in cortical thickness and volume in our cohort (p ​

Published
2020

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