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Human brain imaging typically employs structured and controlled tasks to avoid variable and inconsistent activation patterns. Here we expand this assumption by showing that an extremely open-ended, high-level cognitive task of thinking about an abstract content, loosely defined as "abstract thinking" - leads to highly consistent activation maps. Specifically, we show that activation maps generated during such cognitive process were precisely located relative to borders of well-known networks such as internal speech, visual and motor imagery. The activation patterns allowed decoding the thought condition at >95%. Surprisingly, the activated networks remained the same regardless of changes in thought content. Finally, we found remarkably consistent activation maps across individuals engaged in abstract thinking. This activation bordered, but strictly avoided visual and motor networks. On the other hand, it overlapped with left lateralized language networks. Activation of the default mode network (DMN) during abstract thought was similar to DMN activation during rest. These observations were supported by a quantitative neuronal distance metric analysis. Our results reveal that despite its high level, and varied content nature - abstract thinking activates surprisingly precise and consistent networks in participants' brains., (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)

Recently we proposed that the information contained in spontaneously emerging (resting-state) fluctuations may reflect individually unique neuro-cognitive traits. One prediction of this conjecture, termed the "spontaneous trait reactivation" (STR) hypothesis, is that resting-state activity patterns could be diagnostic of unique personalities, talents and life-styles of individuals. Long-term meditators could provide a unique experimental group to test this hypothesis. Using fMRI we found that, during resting-state, the amplitude of spontaneous fluctuations in long-term mindfulness meditation (MM) practitioners was enhanced in the visual cortex and significantly reduced in the DMN compared to naïve controls. Importantly, during a visual recognition memory task, the MM group showed heightened visual cortex responsivity, concomitant with weaker negative responses in Default Mode Network (DMN) areas. This effect was also reflected in the behavioral performance, where MM practitioners performed significantly faster than the control group. Thus, our results uncover opposite changes in the visual and default mode systems in long-term meditators which are revealed during both rest and task. The results support the STR hypothesis and extend it to the domain of local changes in the magnitude of the spontaneous fluctuations., (Copyright © 2016 Elsevier Inc. All rights reserved.)

Object completion is an inherent property of visual recognition in which objects can be accurately perceived in the presence of substantial obstructions. We have previously shown [Cereb. Cortex 12 (2002) 163] that high-order human object areas are driven partially by local object fragments and partially by global completion effects. Here we explored, through a backward masking paradigm, whether the balance of local and global processing is time dependent, that is, to what extent completion effects evolve at a different time compared to local image representations. In two separate experiments, subjects were presented with three types of images: (a) unobstructed line drawings of animal shapes ("whole"), (b) the same shapes obstructed by a set of parallel stripes ("grid"), and (c) a scrambled version of b in which the stripe position was shifted horizontally, disrupting the relative position of image regions but maintaining the local feature distribution ("scrambled"). Images were presented either for 60 or 250 ms followed by a mask. Both behavioral and fMRI findings from high-order occipitotemporal object areas showed consistently that object selectivity emerges at the same time as the local feature representation. Thus, object completion effects were evident at the same relative magnitude (LO: 0.5 +/- 0.3 and 0.58 +/- 0.04; pFs: 0.62 +/- 0.3 and 0.6 +/- 0.04; 60 and 250 ms, respectively) even at the short presentation durations when overall object activation was greatly reduced.