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Multiple regions in the human brain are dedicated to accomplish the feat of object recognition; yet our brains must also compute the 2D and 3D locations of the objects we encounter in order to make sense of our visual environments. A number of studies have explored how various object category-selective regions are sensitive to and have preferences for specific 2D spatial locations in addition to processing their preferred-stimulus categories, but there is no survey of how these regions respond to depth information. In a blocked functional MRI experiment, subjects viewed a series of category-specific (i.e., faces, objects, scenes) and unspecific (e.g., random moving dots) stimuli with red/green anaglyph glasses. Critically, these stimuli were presented at different depth planes such that they appeared in front of, behind, or at the same (i.e., middle) depth plane as the fixation point (Experiment 1) or simultaneously in front of and behind fixation (i.e., mixed depth; Experiment 2). Comparisons of mean response magnitudes between back, middle, and front depth planes reveal that face and object regions OFA and LOC exhibit a preference for front depths, and motion area MT+ exhibits a strong linear preference for front, followed by middle, followed by back depth planes. In contrast, scene-selective regions PPA and OPA prefer front and/or back depth planes (relative to middle). Moreover, the occipital place area demonstrates a strong preference for "mixed" depth above and beyond back alone, raising potential implications about its particular role in scene perception. Crucially, the observed depth preferences in nearly all areas were evoked irrespective of the semantic stimulus category being viewed. These results reveal that the object category-selective regions may play a role in processing or incorporating depth information that is orthogonal to their primary processing of object category information., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Visual information is initially represented as 2D images on the retina, but our brains are able to transform this input to perceive our rich 3D environment. While many studies have explored 2D spatial representations or depth perception in isolation, it remains unknown if or how these processes interact in human visual cortex. Here we used functional MRI and multi-voxel pattern analysis to investigate the relationship between 2D location and position-in-depth information. We stimulated different 3D locations in a blocked design: each location was defined by horizontal, vertical, and depth position. Participants remained fixated at the center of the screen while passively viewing the peripheral stimuli with red/green anaglyph glasses. Our results revealed a widespread, systematic transition throughout visual cortex. As expected, 2D location information (horizontal and vertical) could be strongly decoded in early visual areas, with reduced decoding higher along the visual hierarchy, consistent with known changes in receptive field sizes. Critically, we found that the decoding of position-in-depth information tracked inversely with the 2D location pattern, with the magnitude of depth decoding gradually increasing from intermediate to higher visual and category regions. Representations of 2D location information became increasingly location-tolerant in later areas, where depth information was also tolerant to changes in 2D location. We propose that spatial representations gradually transition from 2D-dominant to balanced 3D (2D and depth) along the visual hierarchy., (Copyright © 2016 Elsevier Inc. All rights reserved.)

Attention during encoding improves later memory, but how this happens is poorly understood. To investigate the role of attention in memory formation, we combined a variant of a spatial attention cuing task with a subsequent memory fMRI design. Scene stimuli were presented in the periphery to either the left or right of fixation, preceded by a central face cue whose gaze oriented attention to the probable location of the scene. We contrasted activity for scenes appearing in cued versus uncued locations to identify: (1) regions where cuing facilitated processing, and (2) regions involved in reorienting. We then tested how activity in these facilitation and reorienting regions of interest predicted subsequent long-term memory for individual scenes. In facilitation regions such as parahippocampal cortex, greater activity during encoding predicted memory success. In reorienting regions such as right temporoparietal junction, greater activity during encoding predicted memory failure. We interpret these results as evidence that memory formation benefits from attentional facilitation of perceptual processing combined with suppression of the ventral attention network to prevent reorienting to distractors., (Copyright © 2012 Elsevier Inc. All rights reserved.)