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Transcranial magnetic stimulation (TMS) is a powerful tool for the calculation of parameters related to the intracortical excitability and inhibition of the motor cortex. The cortical silent period (CSP) is one such parameter that corresponds to the suppression of muscle activity for a short period after a muscle response to TMS. The duration of the CSP is known to be correlated with the prognosis of brain stroke patients' motor ability. Current methods for the estimation of the CSP duration are very sensitive to the presence of noise. A variational Bayesian formulation of a manifold-constrained hidden Markov model is applied in this paper to the segmentation of a set of multivariate time series (MTS) of electromyographic recordings corresponding to stroke patients and control subjects. A novel index of variability associated to this model is defined and applied to the detection of the silent period interval of the signal and to the estimation of its duration. This model and its associated index are shown to behave robustly in the presence of noise and provide more reliable estimations than the current standard in clinical practice.

Machine Learning (ML) and related methods have of late made significant contributions to solving multidisciplinary problems in the field of oncology diagnosis. Human brain tumor diagnosis, in particular, often relies on the use of non-invasive techniques such as Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS). In this paper, MRS data of human brain tumors are analyzed in detail. The high dimensionality of the MR spectra makes difficult both their classification and the interpretation of the obtained results, thus limiting their usability in practical medical settings. The use of dimensionality reduction techniques is therefore advisable. In this work, we apply feature selection methods and several off-the-shelf classifiers on various ^1H-MRS modalities: long and short echo times and an ad hoc combination of both. The introduction of bootstrap resampling techniques permits the obtention of mean performance estimates and their variability. Our experimental findings indicate that the feature selection process enhances the classification performance compared to using the full set of features. We also show that the use of combined information from the different echo times is a better strategy for small numbers of spectral frequencies; however, the use of ever greater numbers of short echo time frequencies permits the obtention of many models with similar performance. The final induced models offer very attractive solutions both in terms of prediction accuracy and number of involved spectral frequencies, which are also amenable to metabolic interpretation. A linear dimensionality-reduction technique that preserves class discrimination capabilities is used for visualizing the data corresponding to the selected frequencies.

This paper proposes a principled, self-organized, framework to manage two sources of uncertainty that are inherent in intelligent systems for medical decision support, namely outliers and missing data. The framework is applied to magnetic resonance spectra (MRS), which are indicators of the grade of malignancy in brain tumours. A model for multivariate data clustering and visualization, the generative topographic mapping (GTM), is re-formulated as a mixture of Student's t-distributions making it more robust to outliers while supporting the imputation of missing values. An important new development is the extension of the model to provide automatic feature relevance determination. Its effectiveness on the MRS data is demonstrated empirically.