1. Towards simulations of long-term behavior of neural networks: Modeling synaptic plasticity of connections within and between human brain regions
- Author
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Marcus Kaiser, Emmanouil Giannakakis, Bernd Weber, Cheol E. Han, and Frances Hutchings
- Subjects
Brain simulation ,Optimization ,0209 industrial biotechnology ,Brain development ,Traumatic brain injury ,Computer science ,Cognitive Neuroscience ,02 engineering and technology ,Plasticity ,020901 industrial engineering & automation ,Artificial Intelligence ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Quantitative Biology::Neurons and Cognition ,Artificial neural network ,Human brain ,medicine.disease ,Computer Science Applications ,Brief Papers ,medicine.anatomical_structure ,Biological neural network modeling ,Synaptic plasticity ,Neural mass model ,020201 artificial intelligence & image processing ,Neuroscience - Abstract
Highlights • Development of a biological neural network model that allows long term simulation of brain activity. • Optimization of the model using multiple techniques that led to a speed-up of X200. • Presentation of alternative simulation frameworks for long term simulations., Simulations of neural networks can be used to study the direct effect of internal or external changes on brain dynamics. However, some changes are not immediate but occur on the timescale of weeks, months, or years. Examples include effects of strokes, surgical tissue removal, or traumatic brain injury but also gradual changes during brain development. Simulating network activity over a long time, even for a small number of nodes, is a computational challenge. Here, we model a coupled network of human brain regions with a modified Wilson-Cowan model representing dynamics for each region and with synaptic plasticity adjusting connection weights within and between regions. Using strategies ranging from different models for plasticity, vectorization and a different differential equation solver setup, we achieved one second runtime for one second biological time.
- Published
- 2020
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